Publications by authors named "Hadeil Morsi"
Background: Acquired angioedema due to C1-inhibitor deficiency (AAE-C1-INH) is very rare compared to its prototype, hereditary angioedema. An updated characterisation of the AAE-C1-INH cohort in UK is required to inform management.
Objectives: To describe the disease burden of AAE-C1-INH, long-term prophylaxis (LTP) and the clinical, immunochemical and treatment profiles of AAE-associated diseases in UK.
Article Synopsis
- In March 2020, the UK Primary Immunodeficiency Network created a registry to track outcomes of individuals with Primary Immunodeficiency Diseases (PID) and Secondary Immunodeficiency Diseases (SID) after infection with SARS-CoV-2, reporting 310 cases.
- The overall mortality rate was 17.7%, with certain groups experiencing higher rates; for example, Common Variable Immunodeficiency Disease (CVID) had an infection fatality rate (IFR) of 18.3%.
- Individuals with PID and SID faced greater risks in terms of inpatient mortality and generally died at younger ages than the broader population, with risk factors including older age, low lymphocyte count before infection, and existing co-morbidities