Publications by authors named "Hadeel S T Abdelsalam"
Objectives: There is some controversy regarding the clinical significance of cluster of differentiation 38 (CD38) protein in acute myeloid leukemia (AML). We aimed to study the prognostic value of CD38 expression in relation to the standard cytogenetic risk stratification in AML patients.
Methods: In this prospective study, adult patients with AML were diagnosed based on the finding of ≥ 20% blasts in the bone marrow and the flow cytometry.
Article Synopsis
- The study focused on the expression of toll-like receptor-9 (TLR9) in 40 newly diagnosed acute myeloid leukemia (AML) patients compared to 20 healthy controls.
- TLR9 expression was significantly lower in AML patients (median ≤ 1%) and was linked to poorer clinical outcomes, with lower survival rates for those with TLR9 expression ≤ 1%.
- The findings suggest that while TLR9 is present in AML cells, its low expression correlates with advanced disease and worse prognosis.