Development of a Novel Optimized BioEnvironment for proLonged (NOBEL) ex vivo lung preservation.

Current Ex Vivo Lung Perfusion (EVLP) systems are designed to support lungs outside of the body for up to 12 hours, allowing clinicians limited opportunity to assess organ function and viability prior to transplant. However, prolonged EVLP would allow for advanced time-dependent therapies such as immunomodulation, cell-based therapies and gene editing for donor lung repair and reconditioning. Therefore, we have developed a novel optimized bioenvironment for prolonged (NOBEL) EVLP to preserve a donor lung up to 30 hours.

In Vitro Hemolysis Evaluation of the Second Heart Assist Whisper Percutaneous Mechanical Circulatory Support Device.

Background: High rotational pump speeds in percutaneous mechanical circulatory support (pMCS) devices frequently result in hemolysis. Consequently, in vitro hemolysis testing for newly developed devices is essential to mitigate this significant risk. This study compared the degree of hemolysis induced by the Second Heart Assist Whisper pMCS at its maximum pump speed, representing the worst-case scenario, with that of the Impella CP, following American society for testing and materials standards.