Case Report: Complete tomographic resolution of focal choroidal excavation complicated with choroidal neovascularization after anti-VEGF treatment.

Purpose We report a case of focal choroidal excavation (FCE) that resolved after intravitreal injection of anti-vascular endothelial growth factor (VEGF) for choroidal neovascularization (CNV) and we describe its tomographic features. Case report A 43-year-old female presented with blurred vision and metamorphopsia in her left eye (LE) evolving for 10 years. The best corrected visual acuity (BCVA) was 20/20 in the right eye and 20/32 in the LE.

Retinal vein occlusions: an OCT- Angiography analysis.

Aim: To analyze microcirculatory abnormalities, central avascular area and capillary density in OCT-angiography in retinal venous occlusions (RVO).

Methods: This is a descriptive study of 35 patients (35 eyes) with RVO who consulted at the  ophthalmology department of Farhat Hached Hospital in Sousse between January 2014 and July 2018. The diagnosis of retinal venous occlusion was established on clinical examination, fundus photography and fluorescein angiography.

Early post-traumatic pulmonary embolism in intensive care unit: incidence, risks factors, and impact outcome.

Background: Venous thromboembolism (VTE) is a well-established complication of trauma. Recent studies suggest that pulmonary embolism (PE) may occur very early, and even immediately, after injury. The aim of this study is to analyze the incidence, risk factors and prognosis of early PE among ICU trauma patients.

Similar time distortions under the effect of emotion for durations of several minutes and a few seconds.

This study examined the effect of emotion on the judgment of durations of several minutes compared with that of durations of a few seconds. Three experiments were performed on the temporal judgment of emotional stimuli lasting from 2 s to 6 min (Experiment 1) or from 2 to 6 min (Experiment 2 and 3). These involved emotional sounds (Experiment 1 and 2) or virtual reality emotional films (Experiment 3).

Pulmonary embolism in intensive care units: More frequent or more Known? Prospective study of 75 cases.

Purpose: to evaluate the current rate of pulmonary embolism (PE) in our medico-surgical intensive care unit (ICU), to identify risk factors, and to determine the outcome of PE in ICU.

Methods: We performed a prospective cohort study of consecutive patients requiring intensive care admission during a one-year period. We included, in this prospective study, all the patients with confirmed PE admitted in ICU with more than 18 years of age, and expected to stay in ICU for more than 48 hours.

[Post-traumatic carotido-jugular fistula: Case report and review of the literature].

The neck, being not protected by skeleton, is vulnerable to external trauma and injury which can involve blood vessels, muscles, nerves, and trachea. Carotid injuries can be potentially life-threatening by hemorrhage and stroke. We present a case of a 26-year-old manual worker who presented a neck injury caused by a metallic projectile.

Posterior reversible encephalopathy syndrome in leukemic children: a sensitive issue.

Posterior reversible encephalopathy syndrome (PRES) is an acute central nervous system disorder characterized by reversible brain vasogenic edema. We report here a new case of a nine-year-old boy with B-cell acute lymphoblastic leukemia (B-ALL) who developed PRES secondary to induction chemotherapy including dexamethasone (dexamethasone®), vincristine (oncovin(®)), daunorubicin (adriblastine(®)) and intrathecal injection. Cerebral magnetic resonance imaging (MRI) showed high signal intensity on T2 at cortical and sub cortical region of parieto-frontal and parieto-occipital lobes.

[Mediastinal mature teratoma with spontaneous malignant transformation].

Introduction: Malignant teratomas can be either immature teratomas or they can develop after treatment of other malignant germ cell tumors with chemotherapy or radiotherapy. Spontaneous malignant transformation of mature teratomas is very rare.

Observation: We report the case of a patient complaining of atypical chest pain.

Post-traumatic pulmonary embolism in the intensive care unit.

Objective: To determine the predictive factors, clinical manifestations, and the outcome of patients with post-traumatic pulmonary embolism (PE) admitted in the intensive care unit (ICU).

Methods: During a four-year prospective study, a medical committee of six ICU physicians prospectively examined all available data for each trauma patient in order to classify patients according to the level of clinical suspicion of pulmonary thromboembolism. During the study period, all trauma patients admitted to our ICU were classified into two groups.

Outcome analysis and outcome predictors of traumatic head injury in childhood: Analysis of 454 observations.

Aim: To determine factors associated with poor outcome in children suffering traumatic head injury (HI).

Materials And Methods: A retrospective study over an 8-year period including 454 children with traumatic HI admitted in the Intensive Care Unit of a university hospital (Sfax-Tunisia). Basic demographic, clinical, biological and radiological data were recorded on admission and during the ICU stay.

Isolated traumatic head injury in children: Analysis of 276 observations.

Background: To determine predictive factors of mortality among children after isolated traumatic brain injury.

Materials And Methods: In this retrospective study, we included all consecutive children with isolated traumatic brain injury admitted to the 22-bed intensive care unit (ICU) of Habib Bourguiba University Hospital (Sfax, Tunisia). Basic demographic, clinical, biochemical, and radiological data were recorded on admission and during ICU stay.

Antiproliferative effects of withanolides from Withania adpressa.

Extracts of Withania adpressa Coss. (Solanaceae), a medicinal plant endemic to Moroccan Sahara, were tested for their cytotoxicity towards a panel of cancer cell lines (Hep2, HT29, RD, Vero and MDCK), using the (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) [MTT assay, Sigma-Aldrich]. The bioassay-guided fractionation of this plant extracts results a novel withanolide 14alpha,15alpha,17beta ,20beta-tetrahydroxy-1-oxo-(22R)-witha-2,5,24-trienolide and the already identified withanolides F and J extract, semi-purified fractions and pure compounds exhibits potent cytotoxicity against human cancer cell lines tested, in dose-dependent manner.