The MDM2 SNP309 differentially impacts cardiorespiratory fitness in young healthy women and men.

Purpose: Maximal oxygen consumption (VOmax), the predominant index of cardiorespiratory fitness (CRF), is a predictor of whole-body function and longevity in humans. The central cardiac function and the skeletal muscle's capacity to use oxygen are key determinants of VOmax. Murine Double Minute 2 (MDM2), mainly known as an oncogene, could regulate myocardial hypertrophy, skeletal muscle angiogenesis, and oxidative phosphorylation.

Evaluating the Radioactive Waste Produced per Patient by Radiopharmaceutical Sources and Measuring the Radioactive Contamination of Surfaces and Staff at the Bushehr Nuclear Medicine Department.

Background: Nuclear medicine is an integral and developing field in diagnosing and treating diseases. Monitoring individuals' protection and radiation contamination in the workplace is vital for preserving working environments.

Objective: This study aimed to monitor the nuclear medicine department's personnel, environment, and wastes to determine the level of occupational radiation and environmental pollution in Bushehr's nuclear medicine department.

Investigating the Expression Levels of Bax and Bcl-2 Genes in Peripheral Blood Lymphocytes of Industrial Radiation Workers in the Asaluyeh Region.

Background: Industrial radiography uses gamma or X-ray radionuclide sources to investigate the safety of industrial materials. Industrial radiation workers receive the highest occupational radiation doses.

Objective: The present study investigates the relationship between Bax and Bcl-2 gene expression variables in industrial radiation workers.

Protective effects of Panax Ginseng against 131I-induced genotoxicity in patients with differentiated thyroid cancer.

Background: Radioiodine (131I) therapy (RAIT) is associated with oxidative stress (OS)-induced DNA damage in patients with differentiated thyroid cancer (DTC). The goal of this study was to evaluate the possible ameliorating effects of Panax Ginseng (PG) on RAIT-induced genotoxicity in patients with DTC.

Materials And Methods: Forty DTC patients who had received 131I (100 to 175 mCi) were enrolled in this study.

Evaluation of the relationship between γ-H2AX biomarker levels and dose received after radiation exposure in abdominal-pelvic and chest CT scans.

Background: As one of the most informative diagnostic radiation instruments, computed tomography (CT) has seen considerable improvement since its implementation in the 1970s; however, the possibility of low-dose radiation risk after CT procedures is still challenging and little is known about the biological effects of CT exposure on patients. As a result, this research aimed to look at the biological and cytogenetic effects of low-dose abdominal-pelvic and chest CT scans on adults, focusing on the number of γ-H2AX foci formation.

Materials And Methods: Blood tests were taken before and 10 min after CT exams on patients aged 25-55 who were undergoing abdominal-pelvic and chest CT exams with very low-ionizing radiation exposure (TLD doses of 15.

Extremely Low Frequency-Electromagnetic Fields (ELF-EMF) Can Decrease Spermatocyte Count and Motility and Change Testicular Tissue.

Background: Substantial evidence indicates that exposure to extremely low frequency-electromagnetic fields (ELF-EMFs) affects male reproductive system.

Objective: The goal of this study was to evaluate the effects of long-term irradiation with ELF-EMF on sperm quality and quantity and testicular structure.

Material And Methods: In this case-control study, sixty male Sprague-Dawley rats were randomly divided into six groups.

Determination of Diagnostic Reference Level (DRL) in Common Computed Tomography Examinations with the Modified Quality Control-Based Dose Survey Method in Four University Centers: A Comparison of Methods.

Background: The diagnostic reference level (DRL) is measured with different methods in the common Computed tomography (CT) exams, but it has not been measured through the size-specific dose estimate (SSDE) method in Iran, yet.

Objective: This study aimed to calculate the local DRL (LDRL) using the new quality control-based dose survey method (QC) and patients' effective diameter (MQC) and compare them with a data collection method (DC) as well as local national DRLs (NDRL).

Material And Methods: In this cross-sectional study, LDRL, based on the third quartile of volumetric computed tomography dose index (CTDI) and dose length product (DLP) values, was calculated for the four common CT examinations in four CT scan centers affiliated with Shiraz University of Medical Sciences by DC, QC and MQC methods.

Hesperidin Modulates Troponin-1 Serum Level and Decrease Heart Tissue Injury of Irradiated Rats.

Background: The heart is the major dose-limiting organ for radiotherapy of malignant tumor in the mediastanal region.

Objective: This study aims to investigate the radio protective effects of Hesperidin (HES) as a natural flavonoid after localized irradiation of the rat's mediastinum region.

Material And Methods: In this experimental study, we divided sixty male rats into 4 groups (n=15).

Tumor volume-adapted SUV as an alternative to SUV for quantification of small lesions in PET/CT imaging: a proof-of-concept study.

Purpose: SUV is a recommended quantification metric except for small lesions. We aimed to assess the averaged standard uptake value (SUV) as an alternative to SUV for small-lesion quantification.

Materials And Methods: NEMA-like phantom images were reconstructed using OSEM, OSEM + PSF, OSEM + TOF and OSEM + TOF + PSF with two post-smoothing Gaussian filters for different background activity levels.

Design and validation of a hospital emergency department preparedness questionnaire for radiation accidents, nuclear accidents, and nuclear terrorism in Iran.

Background And Objectives: Radiation accidents can cause numerous challenges to hospitals, the appropriate medical responses to which may save the lives of countless people. The present study aimed at the design and validation of an Emergency Department preparedness questionnaire for hospital emergency departments (EDs) in the case of radiation accidents, nuclear accidents, and nuclear terrorism in Iran.

Materials And Methods: This multistage cross-sectional study was conducted in 2019.

Protection effect of cerium oxide nanoparticles against radiation-induced acute lung injuries in rats.

Introduction: Radiation therapy is one of the most common tools for treating cancer. The aim is to deliver adequate doses of radiation to kill cancer cells and the most challenging part during this procedure is to protect normal cells from radiation. One strategy is to use a radioprotector to spare normal tissues from ionizing radiation effects.

Developing a Model for Hospitals' Emergency Department Preparedness in Radiation and Nuclear Incidents and Nuclear Terrorism in Iran.

Objective: To develop a national model for hospitals' Emergency Department (ED) preparedness when facing radiation and nuclear incidents as well as nuclear terrorism in Iran.

Methods: This analytical study was carried out in 2019 via Delphi technique in two rounds and prioritization using a pairwise questionnaire. Using classic Delphi technique and pairwise comparison, the components were given to 32 specialists in emergency medicine, nuclear medicine, medical physics, nuclear physics, radiobiology and radiation protection, health in disaster and emergency, and passive defense.

Evaluation of the effect of hesperidin on vascular endothelial growth factor gene expression in rat skin animal models following cobalt-60 gamma irradiation.

Introduction: Skin is highly prone to radiation damage. Radiation burn is defined as damage to the skin or other biological tissues induced by radiofrequency or ionizing radiation. Vascular endothelial growth factor (VEGF) is a heparin-binded pro-angiogenic factor.

Expression of Bax and Bcl2 Genes in Peripheral Blood Lymphocytes of Patients with Differentiated Thyroid Cancer.

Context: Thyroid cancer is the most common endocrine malignancy worldwide. Iodine-131 is used in the treatment of thyroid cancer with dosage of 100 mCi. In the medical applications of ionizing radiation besides the advantages such as diagnosis and treatment of diseases, the risks arising from exposure should be considered as well.

Radioprotective effect of hesperidin on reducing oxidative stress in the lens tissue of rats.

Introduction: Oxidative stress is a common factor in cataract. Considering the antioxidant properties of hesperidin as a flavanone glycoside from the flavonoid family with radioprotective effect, this study aimed to determine the protective effect of this flavanone glycoside on reducing oxidative stress in the eye lens tissue of mature rats caused by gamma irradiation.

Materials And Methods: A total of 48 adult rats were randomly divided into six groups, namely, control, Dimethyl sulfoxide (DMSO), hesperidin, radiation, radiation + DMSO, and radiation + hesperidin.

Melatonin Role in Ameliorating Radiation-induced Skin Damage: From Theory to Practice (A Review of Literature).

Normal skin is composed of epidermis and dermis. Skin is susceptible to radiation damage because it is a continuously renewing organ containing rapidly proliferating mature cells. Radiation burn is a damage to the skin or other biological tissues caused by exposure to radiofrequency energy or ionizing radiation.

Hesperidin as Radioprotector against Radiation-induced Lung Damage in Rat: A Histopathological Study.

Reactive oxygen species (ROS) are generated by ionizing radiation, and one of the organs commonly affected by ROS is the lung. Radiation-induced lung injury including pneumonia and lung fibrosis is a dose-limiting factor in radiotherapy (RT) of patients with thorax irradiation. Administration of antioxidants has been proved to protect against ROS.

Effects of Hesperidin as a Radio-protector on Apoptosis in Rat Peripheral Blood Lymphocytes after Gamma Radiation.

Introduction: Hesperidin (HES), as the most abundant flavonoid existing in the citrus, is widely used by human daily. The radio-protective effects of Hesperidin have been confirmed in various measurement systems. This study aimed to evaluate the effects of Hesperidin on the changes in the apoptosis level and expression of apoptotic genes target (bax, bcl-2 and ration of bax/bcl-2) in the peripheral blood lymphocytes of male rats after gamma radiation.

Evaluating Radioprotective Effect of Hesperidin on Acute Radiation Damage in the Lung Tissue of Rats.

Background: Oxidative stress plays an important role in the pathogenesis and progression of γ-irradiation-induced cellular damage, Lung is a radiosensitive organ and its damage is a dose-limiting factor in radiotherapy. The administration of dietary antioxidants has been suggested to protect against the succeeding tissue damage. The present study aimed to evaluate the radioprotective efficacy of Hesperidin (HES) against γ-irradiation-induced tissue damage in the lung of male rats.

Histopathological Evaluation of the Effectiveness of Glycyrrhizic Acid as a Radioprotector Against the Development of Radiation-Induced Lung Fibrosis.

Background: Radiotherapy of the thorax often causes lung inflammation leading to fibrosis.

Objectives: The aim of this study was to investigate whether the use of glycyrrhizic acid (GLA) could improve the development of lung fibrosis in irradiated animals.

Materials And Methods: Wistar rats were divided into four groups.

Radioprotective effects of hesperidin on oxidative damages and histopathological changes induced by X-irradiation in rats heart tissue.

This study was carried out to evaluate radioprotective effects of hesperidin (HES) administration before the irradiation on the cardiac oxidative stress and histopathological changes in an experimental rat model. The cardiovascular complications of radiation exposure cause morbidity and mortality in patients who received radiotherapy. HES, an antioxidant flavonoid found in citrus fruits, suggests the protection against the tissue damage.

Radioprotective effect of melatonin on radiation-induced lung injury and lipid peroxidation in rats.

Objective: Free radicals generated by ionizing radiation attack various cellular components such as lipids. The lung is a very radiosensitive organ and its damage is a doselimiting factor in radiotherapy treatments. Melatonin (MLT), the major product of the pineal gland acts as a radioprotective agent.

Oral administration of melatonin modulates the expression of tumor necrosis factor-α (TNF-α) gene in irradiated rat cervical spinal cord.

Aim: We aimed to determine the changes in TNF-α expression and Malondialdehyde (MDA) level in a short time after irradiation. Furthermore, we evaluated the effect of melatonin on the modulation of TNF-α gene expression.

Background: The radio-sensitivity of the cervical spinal cord limits the dose of radiation which can be delivered to tumors in the neck region.

Radioprotective effect of melatonin on the cervical spinal cord in irradiated rats.

Objective: It has been suggested that the vascular endothelial growth factor (VEGF) gene expression plays an important role in radiation-induced injury to the spinal cord. This study assesses the radioprotective effects of N-acetyl-5-methoxytryptamine (melatonin) through its modulation of VEGF expression after localized irradiation of the cervical spinal cord.

Materials And Methods: In this experimental study, we divided 192 male rats into four groups: 1.

Radioprotective effect of melatonin in reducing oxidative stress in rat lenses.

Objective: Ocular morbidity is widely observed when radiotherapy includes the orbit. Oxidative stress generated by irradiation is responsible for this complication. In different studies, it has been shown that melatonin has antioxidative properties and a radioprotective role.