Publications by authors named "Hadar Eini-Rider"

The gut metabolite composition determined by the microbiota has paramount impact on gastrointestinal physiology. However, the role that bacterial metabolites play in communicating with host cells during inflammatory diseases is poorly understood. Here, we aim to identify the microbiota-determined output of the pro-inflammatory metabolite, succinate, and to elucidate the pathways that control transepithelial succinate absorption and subsequent succinate delivery to macrophages.

View Article and Find Full Text PDF

Metabolite transport across cellular membranes is required for bioenergetic processes and metabolic signaling. The solute carrier family 13 (slc13) transporters mediate transport of the metabolites succinate and citrate and hence are of paramount physiological importance. Nevertheless, the mechanisms of slc13 transport and regulation are poorly understood.

View Article and Find Full Text PDF

Background: In the kidney, low urinary citrate increases the risk for developing kidney stones, and elevation of luminal succinate in the juxtaglomerular apparatus increases renin secretion, causing hypertension. Although the association between stone formation and hypertension is well established, the molecular mechanism linking these pathophysiologies has been elusive.

Methods: To investigate the relationship between succinate and citrate/oxalate levels, we assessed blood and urine levels of metabolites, renal protein expression, and BP (using 24-hour telemetric monitoring) in male mice lacking slc26a6 (a transporter that inhibits the succinate transporter NaDC-1 to control citrate absorption from the urinary lumen).

View Article and Find Full Text PDF
Article Synopsis
  • SIRS (Systemic Inflammatory Response Syndrome) is linked to lymphopenia and increased mortality in septic patients, and this study explores how elevated adenosine contributes to these effects.
  • The research involved inducing SIRS in mice through cecal ligation and puncture to assess the impact of adenosine on IL-15 production, revealing that adenosine receptor (AR) activity was diminished in T cells, leading to increased cAMP levels.
  • Findings indicate that AR desensitization and adenosine's inhibition of IL-15 production play a crucial role in SIRS-related lymphopenia, suggesting that targeting adenosine signaling could help improve recovery in septic patients experiencing low white blood cell counts
View Article and Find Full Text PDF