Effects of 100% oxygen on cell division in lung alveoli of squirrel monkeys.

The purpose of this study was to determine the effects of 100% oxygen on cell division in lung alveoli of squirrel monkeys. To accomplish this, squirrel monkeys were exposed to 100% oxygen for up to 5 d. Prior to sacrifice, cells preparing to divide were labeled with tritiated thymidine (3H-Tdr).

Experimental studies on human health effects of air pollutants: I. Design considerations.

Because of the possible threat to public health posed by photochemical air pollution, a need exists for experimental studies of short-term respiratory effects of air pollutant exposure in humans. Such studies require rigorous control and comprehensive documentation of the experimental air environment and exposure conditions to ensure that results are both reliable and relevant to public health questions. In addition to biochemical, behavioral, and clinical evaluations, comprehensive pulmonary testing is required to assure that effects at different levels of the respiratory tract are detected.

Experimental studies on human health effects of air pollutants. III. Two-hour exposure to ozone alone and in combination with other pollutant gases.

Adult male volunteers were exposed to ozone (O3) at 0.25, 0.37, or 0.

Experimental studies on human health effects of air pollutants. II. Four-hour exposure to ozone alone and in combination with other pollutant gases.

Eight adult male volunteers were exposed to ozone (O3) alone and then in combination with nitrogen dioxide and carbon monoxide under conditions simulating ambient air pollution exposures. Four "normal" men showed few or no effects from repeated exposures. Four male volunteers with a history of "hyperreactive" airways, but with normal base line pulmonary function spirometric studies, after O3 exposure developed definite symptoms and decrement in pulmonary function.

Molecular properties of purified (sodium + potassium)-activated adenosine triphosphatases and their subunits from the rectal gland of Squalus acanthias and the electric organ of Electrophorus electricus.

The chemical properties of two highly purified preparations of (sodium + potassium)-activated adenosine triphosphatase (NaK ATPase) and their subunits have been compared. One preparation is derived from the rectal gland of the spiny dogfish shark, Squalus acanthias and the other preparation is derived from the electric organ of the electric eel, Electrophorus electricus. Ouabain binding and phosphorylation from [gamma-32-P]ATP for both enzymes ranged from 4000 to 4300 pmol per mg of protein.

Effects of 60 and 80% oxygen on cell division in lung alveoli of squirrel monkeys.

The purpose of this study was to determine the effects on cell division of 60 and 80% oxygen in the lung alveoli of squirrel monkeys. To accomplish this, squirrel monkeys were exposed to 60 and 80% oxygen for up to 8 d. Prior to sacrifice, cells preparing to divide were labeled with tritiated thymidine (3H-TdR).

Ozone and human blood.

Statistically significant changes (P less than .05) were observed in erythrocytes (RBC) and sera of young adult human males following a single short-term exposure to 0.50 ppm ozone (O3) for 2 3/4 hours.