Determination of paclobutrazol using square wave voltammetry based on a molecularly imprinted polymer and boron-doped copper oxide/graphene nanocomposite.

In the present study, a novel voltammetric sensor based on a boron-doped copper oxide/graphene (B-CuO-Gr) nanocomposite and molecularly imprinted polymer (MIP) was developed for the detection of paclobutrazol (PAC) in apple and orange juice samples. The B-CuO-Gr nanocomposite was prepared using sol-gel and calcination methods. After modifying glassy carbon electrodes with the B-CuO-Gr nanocomposite, PAC-imprinted electrodes were prepared in the presence of 100.

Thiram Determination in Milk Samples by Surface Plasmon Resonance Based on Molecularly Imprinted Polymers and Sulphur-Doped Titanium Dioxide.

In this work, a new surface plasmon resonance (SPR) sensor based on sulphur-doped titanium dioxide (S-TiO) nanostructures and molecularly imprinted polymer (MIP) was presented for thiram (THI) determination in milk samples. Firstly, the S-TiO nanomaterial with a high product yield was prepared by using a facile sol-gel hydrolysis technique with a high product yield. After that, UV polymerization was carried out for the preparation of the THI-imprinted SPR chip based on S-TiO using a mixture including ethylene glycol dimethacrylate (EGDMA) as the cross-linker, N,N'-azobisisobutyronitrile (AIBN) as the initiator, and methacryloylamidoglutamicacid (MAGA) as the monomer.

The Electrochemical Detection of Ochratoxin A in Apple Juice via MnCO Nanostructures Incorporated into Carbon Fibers Containing a Molecularly Imprinting Polymer.

A novel electrochemical sensor based on MnCO nanostructures incorporated into carbon fibers (MnCONS/CF), including a molecularly imprinting polymer (MIP), was developed for the determination of Ochratoxin A (OTA). In this study, a sensitive and selective sensor design for OTA detection was successfully performed by utilizing the selectivity and catalysis properties of MIP and the synthesized MnCONS/CF material at the same time. MnCO nanostructures incorporated into carbon fibers were first characterized by using various analytical techniques.

The protective effect of caffeic acid phenethyl ester in the nephrotoxicity induced by α-cypermethrin.

Alpha cypermethrin (α-CYP) is an insecticide, a member of the group of synthetic pyrethroid pesticides. This study aims to assess the histopathological and biochemical subacute effects of α-CYP on the renal tissues of 48 male Spraque-Dawley adult rats. In this study, the rats were divided into six groups: control, α-CYP (10 mg kg), α-CYP (20 mg kg), caffeic acid phenethyl ester (CAPE) (10 µmol kg), α-CYP + CAPE (10 mg kg), and α-CYP + CAPE (20 mg kg) groups.

Bisphenol A Imprinted Electrochemical Sensor Based on Graphene Quantum Dots with Boron Functionalized g-CN in Food Samples.

A molecular imprinted electrochemical sensor based on boron-functionalized graphitic carbon nitride (B-g-CN) and graphene quantum dots (GQDs) was presented for selective determination of bisphenol A (BPA). In particular, by combining the selectivity and high stability properties, which are the most important advantages of molecular imprinted polymers, and the highly sensitive properties of GQDs/B-g-CN nanocomposite, a highly selective and sensitive analytical method was developed for BPA analysis. Firstly, GQDs/B-g-CN nanocomposite was characterized by using microscopic, spectroscopic, and electrochemical techniques.

Oxidative Stress and Biochemical Alterations in Patients with Head and Multiple Organ Traumas.

Aim: To evaluate paraoxonase (PON), total antioxidant status (TAS), total oxidant status (TOS), high-density lipoproteins (HDL), CRP, AST, ALT, GGT, ALP levels in patients with head and multiple organ traumas.

Material And Methods: The study included 29 male patients undergoing treatment for head and multiple organ traumas. Blood sample analysis was performed on the first, third, and seventh days after trauma.

Manifestations of oxidative stress and liver injury in clothianidin exposed .

This investigation was conducted to evaluate the effects of clothianidin, a neonicotinoid insecticide, on hepatic oxidative stress biomarkers, biochemical indices of blood serum and liver integrity in juvenile following 7, 14 and 21 days of application to environmentally relevant concentrations of 3, 15 and 30 μg/l. The observed hypertrophy caused elevation in hepatosomatic index, a significant increase in serum glucose and a decrease in tissue protein level with extended period of exposure were determined. The treatment resulted in a marked induction in the activities of antioxidant enzymes which were accompanied with simultaneous elevation in MDA and protein carbonyl level reflecting loss of membrane integrity and protein function.

Tissue-specific toxicity of clothianidin on rainbow trout ().

This study was performed to investigate the tissue-specific effects of clothianidin on by evaluating the biochemical and histological alterations following 21 days of treatment to environmentally relevant concentrations of 3, 15, and 30 µg/L. The emerged behavioral changes in feeding and swimming performance were considered as adaptive responses to avoid the chemical. The toxic effect of pesticide on nervous system and osmoregulation was evidenced with the inhibition of AChE and NaK-ATPase.

Alpha lipoic acid attenuates hypoxia-induced apoptosis, inflammation and mitochondrial oxidative stress via inhibition of TRPA1 channel in human glioblastoma cell line.

Apoptosis, overload Ca entry and oxidative stress are induced in neurons by hypoxia. Drug-resistant cancer cells are killed by hypoxic conditions. α-Lipoic acid (ALA) has antioxidant and pro-oxidant functions.

Utilisation of construction and demolition waste as cemented paste backfill material for underground mine openings.

This study presents the utilisation of finely ground construction and demolition waste (CDW) as partial replacement (5-15 wt.%) to sulphide tailings on the short- and long-term strength, durability (i.e.

Chlorpyrifos-induced parkinsonian model in mice: Behavior, histopathology and biochemistry.

Introduction: The aim of this study was to investigate the protective effect of caffeic acid phenethyl ester (CAPE) on Paraoxonase (PON1) activity, and levels of lipid profile, total sialic acid (TSA), total antioxidant capacity (TAC) and total oxidant capacity (TOC) in the plasma and brain tissue of mice with chlorpyrifos-ethyl (CPF)-induced Parkinson.

Material And Method: In the study, 35 male Swiss albino mice were divided into 5 groups including equal number of mice as follows; intraperitoneal injection of saline for mice in control (C) group, subcutaneous injection of 80mg/kg CPF for CPF group, intraperitoneal injection of 10μmol/kg CAPE for CAPE group, subcutaneous injection of 80mg/kg CPF and intraperitoneal injection of 10μmol/kg CAPE for CPF+CAPE group and intraperitoneal injection of 10% ethanol diluted in physiological saline solution for 21days for ethanol (E) group. All the mice were fed with normal feed and tap water ad libitum.

Synergic prooxidant, apoptotic and TRPV1 channel activator effects of alpha-lipoic acid and cisplatin in MCF-7 breast cancer cells.

Background: Resistance to cisplatin (Cisp) in the treatment of breast cancer is a major obstacle. Alpha-lipoic acid (ALA) has both antioxidant and oxidant properties. ALA has been used on stimulation mechanisms of apoptosis and oxidative stress in the treatment of cancer with a combination of chemotherapeutic agents, although its role on molecular mechanisms in the cancer cells has not been clarified yet.

5-Fluorouracil-induced mitochondrial oxidative cytotoxicity and apoptosis are increased in MCF-7 human breast cancer cells by TRPV1 channel activation but not Hypericum perforatum treatment.

5-Fluorouracil (5-FU) is a widely used chemotherapy agent for breast cancer, although drug resistance is a critical issue regarding the use of this agent in the disease. Calcium signaling is a well-known main cause of proliferation and apoptosis in breast cancer cells. Although previous studies have implicated TRPV1 inhibitor, anticancer, and apoptotic roles of Hypericum perforatum (HPer) in several cells, the synergistic inhibition effects of HPer and 5-FU in cancer and the stimulation of ongoing apoptosis have not yet been clarified in MCF-7 cells.

Current scenario of chalcopyrite bioleaching: a review on the recent advances to its heap-leach technology.

Chalcopyrite is the primary copper mineral used for production of copper metal. Today, as a result of rapid industrialization, there has been enormous demand to profitably process the low grade chalcopyrite and "dirty" concentrates through bioleaching. In the current scenario, heap bioleaching is the most advanced and preferred eco-friendly technology for processing of low grade, uneconomic/difficult-to-enrich ores for copper extraction.

Protective effect of omega-3 fatty acid against mercury chloride intoxication in mice.

The aim of this study was to investigate the protective effect of omega-3 fatty acid in HgCI2 toxicity in mice. Levels of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO) and total sialic acid (TSA), and histopathological changes in selected organs were evaluated. Twenty-eight mice were equally divided into 4 groups, namely Groups I-IV.

Utilization of water-reducing admixtures in cemented paste backfill of sulphide-rich mill tailings.

This study presents the effect of three different water-reducing admixtures (WRAs) on the rheological and mechanical properties of cemented paste backfill (CPB) samples. A 28-day strength of > or = 0.7 MPa and the maintenance of the stability (i.

Effect of natural pozzolans as mineral admixture on the performance of cemented-paste backfill of sulphide-rich tailings.

This paper presents the effect of the natural pozzolans as mineral additives on the short- and long-term strength and stability performance of cemented paste backfill (CPB) samples. Prior to their use in CPB studies, the natural pozzolans - the volcanic tuffs (Akkus Trass [AT] and Fatsa Trass [FT]) and pumice (KP) - were tested for their pozzolanic characteristics. These tests revealed that the pozzolanic activity of the natural pozzolans is closely inter-related with their content of reactive silica and, accordingly, KP has the highest pozzolanic activity.

Leachable characteristics of arsenical borogypsum wastes and their potential use in cement production.

In this study; the potential use of arsenical borogypsum wastes (ABW) as a set retarder in cement industry was investigated. The comparative performances of arsenical borogypsum wastes (ABW) and natural gypsum samples (NG1 and NG2) at different proportions in the range of 3-8 wt % were tested based on compressive strength over 1, 2, 7, and 28 days and setting times. The use of ABW was observed to lead to a somewhat slower rate of development of strength of the mortar samples than those of NG1 and NG2 during the curing period of 7 days.

Utilization of industrial waste products as pozzolanic material in cemented paste backfill of high sulphide mill tailings.

In this study, the potential use of the industrial waste products including waste glass (WG), fly ash (FA), granulated blast furnace slag (GBFS) and silica fume (SF) as pozzolanic additive for the partial replacement of ordinary Portland cement (OPC) in cemented paste backfill (CPB) of sulphide-rich mill tailings was investigated. The influence of these industrial waste products on the short- and long-term mechanical performance of CPB was demonstrated. The rate of development of strength of CPB samples tended to slow down when the pozzolanic wastes were incorporated or increased in dosage in the binder phase.