[Microcirculation disorders of the pancreas in cerulein induced acute pancreatitis in rats with regard to nitrogen oxide and heparin].

Unlabelled: Microcirculatory disturbance may play an important role in the development of severe pancreatitis, leading the edematous form of the disease to the necrosis. The aim of this study was to investigate the impact of L-arginine (nitric oxide donor), L-NN (NO synthase inhibitor), and heparin on the pancreas microcirculation, serum interleukin-6 level and microscopic alterations of the pancreas in acute pancreatitis in rats.

Methods: Acute pancreatitis was induced in 72 rats by four intraperitoneal injections of cerulein (CN) (15 micrograms/kg body weight).