Publications by authors named "Habibi M"
Article Synopsis
- Patients with HR+, HER2- breast cancers have lower responses to neoadjuvant therapy, and this study examines the effectiveness of neoadjuvant endocrine therapy (NET) in these patients.
- A total of 18,037 patients participated in the study, with 3,707 receiving NET and 14,330 receiving neoadjuvant chemotherapy (NAC), with NET patients being older on average (64.1 vs. 47.6 years).
- Results showed that node pathologic complete response (pCR) rates were 8.9% for NET compared to 14.9% for NAC, and axillary lymph node dissection (ALND) rates were also lower for NET patients (39.1%
Glutathione (GSH) is a bioactive tripeptide with important physiological functions in animals, plants, and microorganisms. GSH participates in various biochemical reactions in vivo and is known for its antioxidant, anti-allergy, and detoxification properties. This study introduces an innovative photoelectrochemical (PEC) method for GSH detection, leveraging a fluorine-doped tin oxide (FTO) electrode enhanced by TiO nanoflowers and graphitic carbon nitride quantum dots (g-CNQDs).
View Article and Find Full Text PDFInhibition of mitochondrial pyruvate transport via the mitochondrial pyruvate carrier (MPC) has shown beneficial effects in treating metabolic diseases, certain cancers, various forms of neurodegeneration, and hair loss. These benefits arise either from the direct inhibition of mitochondrial pyruvate metabolism or from the metabolic rewiring when pyruvate entry is inhibited. However, current MPC inhibitors are either nonspecific or possess poor pharmacokinetic properties.
View Article and Find Full Text PDFBackground: The adverse effects of aspirin are dose-dependent, and there is controversy surrounding the use of low-dose (LD) aspirin to prevent venous thromboembolism (VTE) following total joint arthroplasty (TJA). This meta-analysis sought to compare the efficacy and complication rate of low-dose (162 mg per day) versus high-dose (HD, 650 mg per day) aspirin after TJA surgery.
Methods: In four main databases, we searched from inception until September 2024 for articles comparing the rate of VTE following TJA(TKA/THA) using only aspirin chemoprophylaxis with different dosages.
Background: Dabrafenib plus trametinib is a novel targeted therapy for low-grade (LGG) and high-grade (HGG) gliomas. This systematic review and meta-analysis aimed to evaluate the safety and efficacy of dabrafenib plus trametinib in LGG and HGG gliomas.
Methods: The electronic databases of PubMed/Medline, Scopus, Embase, and Web of Science were searched from inception to 5 September 2024.
Article Synopsis
- - This study evaluated the consistency of MRI-derived radiomic features for classifying different subtypes of Parkinson's disease (PD) and looked at how ComBat harmonization affects these features and machine learning accuracy.
- - Researchers used MRI scans from 140 PD patients and 70 healthy controls, extracting features from various brain regions at different gray-level discretization levels.
- - Results showed that ComBat harmonization significantly improved the stability of features and classification accuracy, suggesting its importance for better personalized treatment in PD.
Background: The pRESET stent retriever is a self-expanding nitinol stent designed for mechanical thrombectomy in cases of large vessel occlusion during acute ischemic stroke. This systematic review and meta-analysis synthesize the available evidence on the safety and efficacy of the pRESET device.
Methods: This is a systematic review and meta-analysis study conducted based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA).
Role of Statins in the Clinical and Radiologic Outcomes of Patients with Unruptured Intracranial Aneurysm Undergoing Microsurgery or Endovascular Treatment: A Systematic Review and Meta-Analysis.
World Neurosurg
December 2024
Article Synopsis
- Statin pretreatment in patients undergoing endovascular treatment for intracranial aneurysms does not significantly improve the outcomes like complete occlusion rates, but it has some notable effects.
- Statins were associated with an increased risk of ischemic stroke, yet they also reduced the risk of hemorrhagic complications and the likelihood of in-stent stenosis.
- Further research is necessary to better understand the balance of benefits and risks of statin use in these patients.
Article Synopsis
- The SMART coil system is a new type of embolic coil used to treat cerebral aneurysms, involving a platinum coil and a detachment mechanism.
- A study analyzing data from 7 research articles found varying rates of aneurysm occlusion and residuals post-treatment, with a 45% complete occlusion rate and significant long-term success at 66%.
- Overall, the SMART coil system is suggested to be both safe and effective, with low rates of adverse events compared to other treatment options.
Article Synopsis
- - Cognitional heart disease is a major cause of infant mortality, and tissue-engineered vascular grafts present a promising approach for personalized treatment, but current design methods often lack individuality or require manual input.
- - This paper introduces a computational framework that automatically optimizes the shape of patient-specific vascular grafts using techniques like Bayesian optimization and a unique graft deformation algorithm, minimizing the need for human intervention.
- - Evaluation of the method using data from six patients demonstrated improved graft performance in terms of reduced pressure drop and wall shear stress, while also assessing how designs perform under steady versus transient conditions.
Introduction: Traumatic brain injury (TBI) is one of the leading causes of death globally and one of the most important diseases indicated by the World Health Organization (WHO). Several studies have concluded that brain damage can dramatically increase functional connectivity (FC) in the brain. The effects of this hyper-connectivity are not yet fully understood and are being studied by neuroscientists.
View Article and Find Full Text PDFCentral nervous system Tumors, including metastasis, are a considerable source of morbidity and mortality. Currently, treatment options such as surgery, radiotherapy, and chemotherapy have been introduced to prevent the progression of the disease, but still, these patients do not have a good prognosis. Stereotactic radiosurgery (SRS) reduces the damage to the surroundings by focusing the radiation on the tumor tissue.
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- Left bundle branch area pacing (LBBAP) is a new approach to pacing that aims to improve heart function after aortic valve replacement, compared to the traditional right ventricular septal pacing (RVSP).
- The Left Bundle BRAVE study is a clinical trial designed to compare LBBAP and RVSP in patients with severe aortic stenosis and high-degree heart block to see which method better preserves heart function.
- Key outcomes being measured in the study include changes in heart strain and ejection fraction, along with other markers of heart health and patient performance over a 9-month period.
The deterioration of concrete is greatly dependent on the cracks and microcracks development owing to loading or environmental influences. An effective step to avoid the spread of cracks and microcracks is employing of different fibers in concrete and the manufacture of fiber reinforced concrete. On the other hand, fire is one of the cases that always threatens engineering structures.
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- Regeneration of the sciatic nerve relies on multiple signaling pathways, such as MAPK, PI3K/AKT, cAMP, and JAK/STAT, which are crucial for cellular responses necessary for healing.* -
- The cAMP pathway promotes neuronal survival and axon growth, while MAPK supports Schwann cell differentiation and myelination, and PI3K/AKT plays a key role in cell survival and gene expression.* -
- Understanding how these pathways interact is essential for creating new treatments for sciatic nerve injuries, highlighting the need for more research to enhance recovery outcomes.*
Background: Medulloblastoma (MB) is the pediatric population's most frequent malignant intracranial lesions. Prognostication plays a crucial role in optimizing treatment strategy in the MB setting. Several studies have developed ML-based models to predict survival outcomes in individuals with MB.
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- Stroke is a major global health issue, with about one-third of patients facing a second stroke, prompting this study to explore machine learning (ML) algorithms for predicting recurrent strokes.
- The study analyzed 12 research papers involving over 24,000 individuals, revealing that ML models have a sensitivity of 71% and a specificity of 88% for predicting recurrent strokes.
- While the results are promising, indicating that ML could help identify high-risk patients, the study highlights the need for standardized methods and further research to improve the consistency and applicability of these predictive models.
Background: Regarding the newly diagnosed vestibular schwannomas (VSs), active surveillance, microsurgical resection (MS), and stereotactic radiosurgery (SRS) are the leading treatment options. Although SRS is an effective intervention with a low incidence of complications, failure may occur occasionally. Several options, including repeat SRS, are considered salvage treatment after failure of the SRS.
View Article and Find Full Text PDFAs indications for hereditary cancer genetic testing (GT) for patients with breast cancer (BC) expand, breast surgery teams offer GT to newly diagnosed patients to inform surgical plans. There is, however, limited data on the experiences of patients undergoing cancer GT by non-genetic providers. This study used in-depth interviews with 21 women recently diagnosed with BC at a large academic health system to capture their experiences.
View Article and Find Full Text PDFBackground: The Ki-67 index is a histopathological marker that has been reported to be a crucial factor in the biological behavior and prognosis of meningiomas. Several studies have developed artificial intelligence (AI) models to predict the Ki-67 based on radiomics. In this study, we aimed to perform a systematic review and meta-analysis of AI models that predicted the Ki-67 index in meningioma.
View Article and Find Full Text PDFBackground: Recent favorable cohort studies on endovascular therapy for ischemic stroke have predominantly utilized NeVa thrombectomy (NeVa stent retrievers. We carried out a systematic review and meta-analysis to investigate the efficacy and safety of this second-generation stent retriever in acute ischemic stroke patients.
Method: We conducted the study according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines.
Traumatic spinal cord injury (SCI) is a devastating condition that occurs in two phases: primary and secondary injury. These phases contribute to changes in blood vessels and the influx of inflammatory cells such as neutrophils and lymphocytes. The biomarker known as the neutrophil-to-lymphocyte ratio (NLR) has been suggested as being highly valuable in predicting outcomes for patients with traumatic brain injury, acute ischemic stroke, and traumatic spinal cord injury.
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