Publications by authors named "Habib J"
Objective: To investigate whether tangential versus segmental portomesenteric venous resection (PVR) impacts surgical and oncological outcome in patients undergoing pancreatoduodenectomy for pancreatic cancer with portomesenteric vein (PMV) involvement.
Summary Background Data: Current comparative studies on tangential versus segmental PVR as part of pancreatoduodenectomy for pancreatic cancer include all degrees of PMV involvement, including cases where tangential PVR may not be a feasible approach, limiting the clinical applicability.
Methods: International retrospective study in 10 centers from 5 countries, including all consecutive patients after pancreatoduodenectomy with PVR for pancreatic cancer with ≤180° PMV involvement on cross-sectional imaging at diagnosis (2014-2020).
Background: To improve outcomes for patients with pancreatic ductal adenocarcinoma, a complete resection is crucial. However, evidence regarding the impact of microscopically positive surgical margins (R1) on recurrence is conflicting due to varying definitions and limited populations of patients with borderline-resectable and locally advanced pancreatic cancer. Therefore, we aimed to determine the impact of the resection margin status on recurrence and survival in patients with pancreatic ductal adenocarcinoma stratified by local tumor stage.
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- This study investigates early recurrence in patients with pancreatic ductal adenocarcinoma (PDAC) derived from intraductal papillary mucinous neoplasm (IPMN), aiming to identify predictors to help guide patient management.
- The research found that early recurrence is defined as occurring within 10.5 months post-surgery, affecting 38% of patients who experienced recurrence, with CA19-9 levels and N2 disease being significant predictors.
- Adjuvant chemotherapy showed a survival advantage only for high-risk patients, highlighting the importance of risk stratification for better treatment outcomes.
Objectives: To evaluate patient preferences for decision-making role in the management of intraductal papillary mucinous neoplasms (IPMNs) of the pancreas and to identify individual characteristics associated with those preferences.
Background: Management of IPMNs is rooted in uncertainty with current guidelines failing to incorporate patients' preferences and values.
Methods: A representative sample of participants aged 40-70 were recruited to evaluate a clinical vignette where they were given the option to undergo surveillance or surgical resection of their IPMN.
Purpose: Dynamics of carbohydrate antigen 19-9 (CA19-9) often inform treatment decisions during and after neoadjuvant chemotherapy (NAT) of patients with pancreatic ductal adenocarcinoma (PDAC). However, considerable dispute persists regarding the clinical relevance of specific CA19-9 thresholds and dynamics. Therefore, we aimed to define optimal thresholds for CA19-9 values and create a biochemically driven composite score to predict survival in CA19-9-producing patients with PDAC after NAT.
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- The study investigates whether total pancreatectomy (TP) provides better oncological outcomes than partial pancreatectomy (PP) for patients with high-risk IPMN-associated cancer, focusing on local recurrence and secondary progression.
- It compares data from 359 patients, showing that while TP offers improved local disease-free survival (local-DFS), there is no significant difference in overall survival (OS) between TP and PP.
- The findings suggest that TP could be more beneficial for younger patients who are likely to benefit from reduced recurrence risk, while elderly patients may not see the same advantage in OS.
Objective: To measure the rate of LTS in resected PDAC and determine the association between predictors of OS and LTS.
Summary Background Data: Long-term survival (>5 y, LTS) remains rare in pancreatic ductal adenocarcinoma (PDAC). Multiple predictors of overall survival (OS) are known but their association with LTS remains unclear.
Background: The American Joint Committee on Cancer (AJCC) eighth edition is based on pancreatic intraepithelial neoplasia-derived pancreatic ductal adenocarcinoma (PDAC), a biologically distinct entity from intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic cancer. The role of nodal disease and the AJCC's prognostic utility for IPMN-derived pancreatic cancer are unclear. This study aimed to evaluate the prognostic role of nodal disease and the AJCC eighth-edition N-staging for IPMN-derived pancreatic cancer.
View Article and Find Full Text PDFObjective: To assess the prognostic impact of margin status in patients with resected intraductal papillary mucinous neoplasms (IPMN)-derived pancreatic ductal adenocarcinoma (PDAC) and to inform future intraoperative decision-making on handling differing degrees of dysplasia on frozen section.
Summary Background Data: The ideal oncologic surgical outcome is a negative transection margin with normal pancreatic epithelium left behind. However, the prognostic significance of reresecting certain degrees of dysplasia or invasive cancer at the pancreatic neck margin during pancreatectomy for IPMN-derived PDAC is debatable.
Article Synopsis
- This study investigates the effectiveness of adjuvant chemotherapy for patients with pancreatic ductal adenocarcinoma (PDAC) derived from intraductal papillary mucinous neoplasm (IPMN), highlighting the need for tailored treatment approaches due to limited evidence on this specific type of cancer.
- In a cohort of 1,031 patients, factors like nodal disease and elevated levels of carbohydrate antigen 19-9 (CA19-9) were linked to worse overall survival, with high-risk patients showing significant survival benefits from adjuvant chemotherapy.
- The findings suggest that a significant portion of patients (approximately 79.3%) are either overtreated or undertreated, emphasizing the
The notion that technically resectable pancreatic ductal adenocarcinoma presents as localized disease is now known to be inaccurate. Evidence supports that most patients have subclinical systemic dissemination at the time of diagnosis. It is now widely accepted that both a local and systemic component of disease coexist, each requiring treatment of improved survival and potential cure.
View Article and Find Full Text PDFBackground And Aim: Intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic ductal adenocarcinoma (PDAC) management is generally extrapolated from pancreatic intraepithelial neoplasia (PanIN)-derived PDAC guidelines. However, these are biologically divergent, and heterogeneity further exists between tubular and colloid subtypes.
Methods: Consecutive upfront surgery patients with PanIN-derived and IPMN-derived PDAC were retrospectively identified from international centers (2000-2019).
Article Synopsis
- Researchers studied a classification system called T1 sub-staging for IPMN-derived pancreatic ductal adenocarcinoma (PDAC), aiming to better understand its characteristics compared to other types of PDAC.
- The study involved 747 surgery patients and found that increased T-stages correlated with worse overall survival, more advanced disease features, and higher recurrence rates.
- The findings support the validity of T1 sub-staging, indicating that higher sub-stages relate to poorer outcomes and suggesting its importance in clinical assessments.
Article Synopsis
- - The study investigates the effects of different surgical procedures (pancreatoduodenectomy, distal pancreatectomy, and total pancreatectomy) on outcomes for patients with pancreatic neck tumors, finding similar rates of successful tumor removal (R0-resection) across these methods.
- - Among 846 patients analyzed, results showed significant differences in lymph node involvement and the number of lymph nodes examined, with total pancreatectomy associated with worse survival rates compared to pancreatoduodenectomy.
- - The findings suggest that while distal pancreatectomy may lead to inadequate lymph node removal, this did not adversely affect patient survival, indicating that total pancreatectomy does not provide additional survival benefits over partial resections.
Background Objectives: The aim of this study was to determine the role of site-specific metastatic patterns over time and assess factors associated with extended survival in metastatic PDAC. Half of all patients with pancreatic ductal adenocarcinoma (PDAC) present with metastatic disease. The site of metastasis plays a crucial role in clinical decision making due to its prognostic value.
View Article and Find Full Text PDFObjectives: Although prevalent in 50%-90% of pancreatic ductal adenocarcinomas, the clinical relevance of "cancerization of ducts" (COD) remains unknown.
Methods: Pathologists retrospectively reviewed slides classifying prevalence of COD. Histopathological parameters, location of first recurrence, recurrence-free survival (RFS), and overall survival (OS) were collected from the institutional pancreatectomy registry.
Article Synopsis
- The study seeks to determine the minimum and optimal number of lymph nodes (LNs) needed for effective staging and determining survival outcomes in patients with intraductal papillary mucinous neoplasm (IPMN)-derived pancreatic ductal adenocarcinoma (PDAC).
- Current guidelines suggest a minimum of 12-15 LNs based on different cancer types, but this study specifically evaluates the IPMN subtype, showing that at least 10 LNs are necessary for accurate staging.
- The findings indicate that examining 20 or more LNs is linked to significantly better overall survival rates (80.3 months vs. 37.2 months), with optimal cut-off points varying based on the type of surgical procedure performed.
Ticks are major vectors of various pathogens of health importance, such as bacteria, viruses and parasites. The problems associated with ticks and vector-borne pathogens are increasing in mountain areas, particularly in connection with global climate change. We collected ticks (n = 2,081) from chamois and mouflon in 4 mountainous areas of France.
View Article and Find Full Text PDFBackground: The role of CD161 expression on CD8 T cells in tumor immunology has been explored in a few studies, and the clinical significance of CD161CD8 T cells in pancreatic ductal adenocarcinoma (PDAC) remains unclear. This study seeks to clarify the prognostic value and molecular characteristics linked to CD161CD8 T cell infiltration in PDAC.
Methods: This study included 186 patients with confirmed PDAC histology after radical resection.
Pancreatic ductal adenocarcinoma (PDAC) remains associated with poor outcomes with a 5-year survival of 12% across all stages of the disease. These poor outcomes are driven by a delay in diagnosis and an early propensity for systemic dissemination of the disease. Recently, aggressive surgical approaches involving complex vascular resections and reconstructions have become more common, thus allowing more locally advanced tumors to be resected.
View Article and Find Full Text PDFObjectives: Most patients with intraductal papillary mucinous neoplasms (IPMNs) are diagnosed with a solitary lesion; however, the presence of skip lesions, not appreciable on imaging, has been described. Postoperatively, these missed lesions can continue to grow and potentially become cancerous. Intraoperative pancreatoscopy (IOP) may facilitate detection of such skip lesions in the remnant gland.
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