Publications by authors named "Habib A Serhan"
Article Synopsis
- The study focuses on creating patient-derived organoid (PDO) models from muscle-invasive bladder cancer tumors to better predict therapy responses and improve treatment outcomes.
- Researchers collected tumor samples from bladder cancer patients to develop these PDOs and tested them against various drugs in a lab setting, using advanced molecular profiling techniques to assess their characteristics.
- The findings showed that short-term PDOs accurately reflect the original tumors and identified potential biomarkers associated with drug responses, particularly for gemcitabine, but further validation of these results is necessary.
Fatty acid synthesis (FAS) has been shown to play a key role in the survival of brain-metastatic (BM) breast cancer. We demonstrate that the fatty acid synthase inhibitor TVB-2640 synergizes with the topoisomerase inhibitor SN-38 in triple-negative breast cancer (TNBC) BM cell lines, upregulates FAS and downregulates cell cycle progression gene expression, and slows the motility of TNBC BM cell lines. The combination of SN-38 and TVB-2640 warrants further consideration as a potential therapeutic option in TNBC BMs.
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