Optimal Renal Artery-Aorta Angulation Revealed by Flow Simulation.

Introduction: In the circulatory system, the vessel branching angle may have hemodynamic consequences. We hypothesized that there is a hemodynamically optimal range for the renal artery's branching angle.

Methods: Data on the posttransplant kinetics of estimated glomerular filtration rate (eGFR) were analyzed according to the donor and implant sides (right-to-right and left-to-right position; n = 46).

In silico assessment of electrophysiological neuronal recordings mediated by magnetoelectric nanoparticles.

Magnetoelectric materials hold untapped potential to revolutionize biomedical technologies. Sensing of biophysical processes in the brain is a particularly attractive application, with the prospect of using magnetoelectric nanoparticles (MENPs) as injectable agents for rapid brain-wide modulation and recording. Recent studies have demonstrated wireless brain stimulation in vivo using MENPs synthesized from cobalt ferrite (CFO) cores coated with piezoelectric barium titanate (BTO) shells.

Author Correction: Visualization of mucosal field in HPV positive and negative oropharyngeal squamous cell carcinomas: combined genomic and radiology based 3D model.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Visualization of mucosal field in HPV positive and negative oropharyngeal squamous cell carcinomas: combined genomic and radiology based 3D model.

The aim of this study was to visualize the tumor propagation and surrounding mucosal field in radiography-based 3D model for advanced stage HNSCC and combine it with HPV genotyping and miRNA expression characterization of the visualized area. 25 patients with T1-3 clinical stage HNSCC were enrolled in mapping biopsy sampling. Biopsy samples were evaluated for HPV positivity and miR-21-5p, miR-143, miR-155, miR-221-5p expression in Digital Droplet PCR system.

Poppy Seed Tea: A Short Review and Case Study.

Unwashed poppy seeds are widely available online through private websites or via well-known sellers such as eBay and Amazon. These seeds can be used to produce a tea that contains an opioid content sufficient to produce psychoactive effects and to cause withdrawal symptoms when discontinued abruptly, yet their sale and distribution is legal in the United States. Clinicians may not be aware of poppy seed tea and some individuals may use it habitually or as an analgesic.

Experimental observations of soliton wave trains in electron beams.

The first experimental observation of a Korteweg-de Vries-type soliton wave train in intense electron beams is reported. A narrow, large-amplitude perturbation on a long-pulse beam is observed to steepen and spawn a soliton wave train. The pulse width and amplitude of each peak remain unchanged over a long propagation distance, and the amplitude is inversely proportional to the square of the width.

Neurologic evaluations in normal-tension glaucoma workups: are they worth the effort?

Background: Normal-tension glaucoma is a chronic progressive optic neuropathy of unknown etiology. Neuro-imaging workup in these patients is controversial.

Objectives: To determine the value of routine neurologic and neuro-ophthalmologic evaluations in patients with NTG.

Validation of high-resolution echocardiography and magnetic resonance imaging vs. high-fidelity catheterization in experimental pulmonary hypertension.

High-frequency echocardiography and high-field-strength magnetic resonance imaging (MRI) are new noninvasive methods for quantifying pulmonary arterial hypertension (PAH) and right ventricular (RV) hypertrophy (RVH). We compared these noninvasive methods of assessing the pulmonary circulation to the gold standard, cardiac catheterization (micromanometer-tipped catheters), in rats with monocrotaline-induced PAH and normal controls. Closed-chest, Sprague-Dawley rats were anesthetized with inhaled isoflurane (25 monocrotaline, 6 age-matched controls).

Circumferential myocardial strain in cardiomyopathy with and without left bundle branch block.

Background: Cardiac resynchronization therapy (CRT) has been shown to decrease mortality in 60-70% of advanced heart failure patients with left bundle branch block (LBBB) and QRS duration > 120 ms. There have been intense efforts to find reproducible non-invasive parameters to predict CRT response. We hypothesized that different left ventricular contraction patterns may exist in LBBB patients with depressed systolic function and applied tagged cardiovascular magnetic resonance (CMR) to assess circumferential strain in this population.

The inhibition of pyruvate dehydrogenase kinase improves impaired cardiac function and electrical remodeling in two models of right ventricular hypertrophy: resuscitating the hibernating right ventricle.

Right ventricular hypertrophy (RVH) and RV failure contribute to morbidity and mortality in pulmonary arterial hypertension (PAH). The cause of RV dysfunction and the feasibility of therapeutically targeting the RV are uncertain. We hypothesized that RV dysfunction and electrical remodeling in RVH result, in part, from a glycolytic shift in the myocyte, caused by activation of pyruvate dehydrogenase kinase (PDK).

Corneal thickness measurements in normal-tension glaucoma workups: is it worth the effort?

Purpose: To correlate central corneal thickness (CCT) and intraocular pressure (IOP) with disease severity in normal-tension glaucoma (NTG) patients.

Methods: We conducted a retrospective review of all patients diagnosed with NTG in our institution between 2002 and 2006. NTG was diagnosed according to the glaucomatous visual fields loss, glaucomatous optic disc cupping, and an IOP <22 mm Hg on diurnal curve measurements.

Effects of regional dysfunction and late gadolinium enhancement on global right ventricular function and exercise capacity in patients with repaired tetralogy of Fallot.

Background: The underlying mechanisms that contribute to global right ventricular (RV) dysfunction in patients with repaired tetralogy of Fallot are incompletely understood. We therefore sought to quantify regional RV abnormalities and to determine the relationship of these to global RV function and exercise capacity.

Methods And Results: Clinical and cardiac magnetic resonance data from 62 consecutive patients with repaired tetralogy of Fallot were analyzed (median age at follow-up 23 years [limits 9 to 67 years]).

In vivo MRI-Based 3D FSI RV/LV Models for Human Right Ventricle and Patch Design for Potential Computer-Aided Surgery Optimization.

Right ventricular dysfunction is one of the more common causes of heart failure in patients with congenital heart defects. Use of computer-assisted procedures is becoming more popular in clinical decision making process and computer-aided surgeries. A 3D in vivo MRI-based RV/LV combination model with fluid-structure interaction (FSI), RV-LV interaction, and RV-patch interaction was introduced to perform mechanical analysis for human right ventricle with potential clinical applications.

The University of Maryland electron ring: a platform for study of galactic dynamics on a laboratory scale.

The University of Maryland electron ring (UMER) is a novel experimental storage ring designed to investigate the dynamics of large systems of collisionless particles that nevertheless interact via collective mechanisms. Heavily diagnosed and designed to circulate a 100 mA electron beam at 10 keV for several turns, UMER allows us to follow the evolution of the beam over a large number of dynamical periods. Given the similarity of dynamics between the Coulomb forces and gravitational forces, it is possible to design beam experiments that will simulate such astrophysical events as galactic merger, for instance.

Three-dimensional systolic kinematics of the right ventricle.

The right ventricle (RV) of the heart is responsible for pumping blood to the lungs. Its kinematics are not as well understood as that of the left ventricle (LV) due to its thin wall and asymmetric geometry. In this study, the combination of tagged MRI and three-dimensional (3-D) image-processing techniques was used to reconstruct 3-D RV-LV motion and deformation.

Three-dimensional motion reconstruction and analysis of the right ventricle using tagged MRI.

Right ventricular (RV) dysfunction can serve as an indicator of heart and lung disease and can adversely affect the left ventricle. However, normal RV function must be characterized before abnormal states can be detected. We describe a method for reconstructing the 3D motion of the RV by fitting a deformable model to tag and contour data extracted from multiview tagged magnetic resonance images.

Normalization of blood carbon dioxide levels by transition from conventional ventilatory support to noninvasive inspiratory aids.

Chronic hypocapnia seems to be common in long-term ventilator assisted individuals (VAIs) with paralytic/restrictive respiratory conditions. It has predominantly been reported for VAIs using intermittent positive pressure ventilation (IPPV) delivered via tracheostomy tubes. Chronic hypocapnia decreases ventilator-free breathing time (VFBT) and may be associated with increased bone resorption.

Acquired protein C and S deficiency, inflammatory bowel disease and cerebral arterial thrombosis.

Thromboembolic complications may occur in inflammatory bowel disease. Recently, we had the opportunity to observe a case of a cerebral arterial thrombosis in a young patient with active ulcerative colitis. Investigation of blood coagulation revealed a temporary Protein C, Protein S and Factor II deficiency.

Enterolithiasis: report of two cases.

Two cases of enterolithiasis of the small intestine are reported. In the first patient, enterolithiasis recurred two years after the discovery of an enterolith due to a stricture of the ileum. An enterolith was found in a huge jejunal diverticulum at post-mortem examination in the second patient.