Accuracy of Noninvasive Blood Pressure Monitoring in Critically Ill Adults.

Blood pressure (BP) is routinely invasively monitored by an arterial catheter in the intensive care unit (ICU). However, the available data comparing the accuracy of noninvasive methods to arterial catheters for measuring BP in the ICU are limited by small numbers and diverse methodologies. To determine agreement between invasive arterial blood pressure monitoring (IABP) and noninvasive blood pressure (NIBP) in critically ill patients.

Large-Area Epitaxial Mott Insulating 1T-TaSe Monolayer on GaP(111)B.

Two-dimensional Mott materials have recently been reported in the dichalcogenide family with high potential for Mottronic applications. Nevertheless, their widespread use as a single or few layers is hampered by their limited device integration resulting from their growth on graphene, a metallic substrate. Here, we report on the fabrication of 1T-TaSe monolayers grown by molecular beam epitaxy on semiconducting gallium phosphide substrates.

A Liquid Mirror Resonator.

We present the first experimental demonstration of a Fabry‒Perot resonator that utilizes total internal reflection from a liquid-gas interface. Our hybrid resonator hosts both optical and capillary waves that mutually interact. Except for the almost perfect reflection by the oil-air interface at incident angles smaller than the critical angle, reflections from the liquid-phase boundary permit optically examining thermal fluctuations and capillary waves at the oil surface.

Protein Design Using Physics Informed Neural Networks.

The inverse protein folding problem, also known as protein sequence design, seeks to predict an amino acid sequence that folds into a specific structure and performs a specific function. Recent advancements in machine learning techniques have been successful in generating functional sequences, outperforming previous energy function-based methods. However, these machine learning methods are limited in their interoperability and robustness, especially when designing proteins that must function under non-ambient conditions, such as high temperature, extreme pH, or in various ionic solvents.

Mimetic Neural Networks: A Unified Framework for Protein Design and Folding.

Recent advancements in machine learning techniques for protein structure prediction motivate better results in its inverse problem-protein design. In this work we introduce a new graph mimetic neural network, MimNet, and show that it is possible to build a reversible architecture that solves the structure and design problems in tandem, allowing to improve protein backbone design when the structure is better estimated. We use the ProteinNet data set and show that the state of the art results in protein design can be met and even improved, given recent architectures for protein folding.

A Soft Labeling Approach to Develop Automated Algorithms that Incorporate Uncertainty in Pulmonary Opacification on Chest CT using COVID-19 Pneumonia.

Rationale And Objectives: Hard data labels for automated algorithm training are binary and cannot incorporate uncertainty between labels. We proposed and evaluated a soft labeling methodology to quantify opacification and percent well-aerated lung (%WAL) on chest CT, that considers uncertainty in segmenting pulmonary opacifications and reduces labeling burden.

Materials And Methods: We retrospectively sourced 760 COVID-19 chest CT scans from five international centers between January and June 2020.

Public Health Nurse-delivered Group Cognitive Behavioural Therapy for Postpartum Depression: A Randomized Controlled Trial.

Objectives: To examine the effectiveness of group cognitive behavioural therapy (CBT) for postpartum depression (PPD) delivered by public health nurses with little to no previous psychiatric training at improving depression, worry, social support and the mother-infant relationship.

Methods: Mothers (n = 141) living in Ontario, Canada with Edinburgh Postnatal Depression Scale Scores ≥10 and an infant <12 months of age were randomized to receive nine weekly 2-h sessions of in-person group CBT for PPD delivered by two public health nurses plus treatment as usual (TAU; experimental group) or TAU alone (control group). Primary outcomes were change in EPDS score and current major depressive disorder (Mini International Neuropsychiatric Interview) assessed immediately post-treatment (T2).

Outcomes of renal replacement therapy in the critically ill with COVID-19.

Objective: To describe outcomes of critically ill patients with COVID-19, particularly the association of renal replacement therapy to mortality.

Design: A single-center prospective observational study was carried out.

Setting: ICU of a tertiary care center.

Outcomes of renal replacement therapy in the critically ill with COVID-19.

Objective: To describe outcomes of critically ill patients with COVID-19, particularly the association of renal replacement therapy to mortality.

Design: A single-center prospective observational study was carried out.

Setting: ICU of a tertiary care center.

The Biology of Vasopressin.

Vasopressins are evolutionarily conserved peptide hormones. Mammalian vasopressin functions systemically as an antidiuretic and regulator of blood and cardiac flow essential for adapting to terrestrial environments. Moreover, vasopressin acts centrally as a neurohormone involved in social and parental behavior and stress response.

Spatially explicit removal strategies increase the efficiency of invasive plant species control.

Effective management strategies are needed to control expansion of invasive alien plant species and attenuate economic and ecological impacts. While previous theoretical studies have assessed optimal control strategies that balance economic costs and ecological benefits, less attention has been paid to the ways in which the spatial characteristics of individual patches may mediate the effectiveness of management strategies. We developed a spatially explicit cellular automaton model for invasive species spread, and compared the effectiveness of seven control strategies.

Cooperative Energy Transfer Controls the Spontaneous Emission Rate Beyond Field Enhancement Limits.

Quantum emitters located in proximity to a metal nanostructure individually transfer their energy via near-field excitation of surface plasmons. The energy transfer process increases the spontaneous emission (SE) rate due to plasmon-enhanced local field. Here, we demonstrate a significant acceleration of the quantum emitter SE rate in a plasmonic nanocavity due to cooperative energy transfer (CET) from plasmon-correlated emitters.

GlymphVIS: Visualizing Glymphatic Transport Pathways Using Regularized Optimal Transport.

The glymphatic system (GS) is a transit passage that facil-itates brain metabolic waste removal and its dysfunction has been asso-ciated with neurodegenerative diseases such as Alzheimer's disease. The GS has been studied by acquiring temporal contrast enhanced magnetic resonance imaging (MRI) sequences of a rodent brain, and tracking the cerebrospinal fluid injected contrast agent as it flows through the GS. We present here a novel visualization framework, GlymphVIS, which uses regularized optimal transport (OT) to study the flow behavior between time points at which the images are taken.

Mucinous Cystadenoma in Children and Adolescents.

Study Objective: Mucinous cystadenomas (MCAs) are benign epithelial ovarian tumors that occur rarely in children and adolescents. Because children and adolescents typically have their childbearing years ahead of them, conservative therapy is indicated. However, there is concern that ovarian cystectomy might be associated with significant recurrence risk in patients with MCA.

Evaluating the effectiveness of a brief group cognitive behavioural therapy intervention for perinatal depression.

Little is known about the effectiveness of group cognitive behavioural therapy (CBT) in women with perinatal depression (PND) and psychiatric comorbidities. Thirty-four women with PND (sixty-two percent with comorbidity) completed a 9-week CBT group. Eighty percent showed a clinically significant improvement in depressive symptoms.

Botulinum Neurotoxin A for Parotid Enlargement in Cystic Fibrosis: The First Case Report.

Cystic fibrosis (CF) is the most common lethal autosomal recessive genetic disease associated with exocrine gland dysfunction. Salivary gland involvement is a common finding. The literature on submaxillary gland involvement has failed to address the parotid gland and any specific treatment of salivary gland manifestations of CF.

Cognitive-behavioral group treatment for perinatal anxiety: a pilot study.

Along with physical and biological changes, a tremendous amount of upheaval and adjustment accompany the pregnancy and postpartum period of a woman's life that together can often result in what is commonly known as postpartum depression. However, anxiety disorders have been found to be more frequent than depression during pregnancy and at least as common, if not more so, during the postpartum period, e.g.

From data to insight: work practices of analysts in the enterprise.

With greater availability of data, businesses are increasingly becoming data-driven enterprises, establishing standards for data acquisition, processing, infrastructure, and decision making. Enterprises now have people dedicated to performing analytic work to support decision makers. To better understand analytic work, particularly the role of enterprise business analysts, researchers interviewed 34 analysts at a large corporation.

Cognitive-behavioral group treatment for menopausal symptoms: a pilot study.

The menopausal transition is frequently accompanied by adverse physical and emotional changes that can significantly impact a woman's quality of life. Hormone replacement therapy has been the most commonly used menopause-related treatment to date, particularly for the alleviation of vasomotor symptoms; recent studies, however, have questioned its long-term safety for some women. We aimed to develop a cognitive-behavioral group treatment (CBGT) program as an alternative or complementary treatment option for reducing the frequency and intensity of debilitating menopausal symptoms in midlife women.

Effects of quetiapine extended release on sleep and quality of life in midlife women with major depressive disorder.

Depression during midlife years may lead to significant sleep disturbances and adversely impact quality of life (QOL). In this report, we examined the effects of treatment with quetiapine extended release (XR), 150-300 mg/day, on sleep and QOL in 23 midlife women with major depressive disorder (MDD). Quetiapine XR improved subjective sleep distress, overall sleep parameters, and sleep-related QOL, ultimately leading to significant improvement in menopause-related QOL.

Automatic Alignment of Myocardial Perfusion Images With Contrast-Enhanced Cardiac Computed Tomography.

Explicit fusion of perfusion data from Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) with coronary artery anatomy from Computed Tomographic Coronary Angiography (CTA) has been shown to improve the diagnostic yield for coronary artery disease (CAD) compared to either modality alone. However, most clinically available methods were developed for multimodal scanners or require interactive alignment prior to display and analysis. A new approach was developed to register the two distributions obtained either from a single multimodal imager or from separate scanners, and a preliminary validation was undertaken to compare the automatic alignment to interactive alignment by two experts.

Automatic Alignment of Myocardial Perfusion Images with Contrast Cardiac Tomography.

Explicit fusion of perfusion data from Positron Emission Tomography (PET) or Single Photon Emission Computed Tomography (SPECT) with coronary artery anatomy from Computed Tomographic Coronary Angiography (CTCA) has been shown to improve the diagnostic yield for coronary artery disease (CAD) compared to either modality alone. However, most clinically available methods were developed for multimodal scanners or require interactive alignment prior to display and analysis. A new approach was developed to register and display the two distributions obtained either from a single multimodal imager or from separate scanners, and a preliminary validation was undertaken using interactive alignment by experts.