Publications by authors named "Haben Tesfu"
The rise in antibiotic resistance among pathogenic microorganisms has created an imbalance in the drugs available for treatment, in part due to the slow development of new antibiotics. Cystic fibrosis (CF) patients are highly susceptible to antibiotic-resistant pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). Phloroglucinols and related polyketide natural products have demonstrated antimicrobial activity against a number of Gram-positive bacteria including S.
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- The study presents a method using next-generation sequencing to identify antibiotic targets, specifically focusing on a novel antibacterial compound, C109.
- C109 effectively inhibits bacterial cell division by disrupting the function and localization of the essential protein FtsZ.
- The compound shows promise against multiple cystic fibrosis pathogens and enhances the effectiveness of existing antibiotics, suggesting it could be a viable candidate for future drug development.