The interleukin-1 receptor type I promotes the development of aging-associated cardiomyopathy in mice.

Background: Aging is associated with metabolic and structural changes causing heart failure with preserved ejection fraction (HFpEF). Interleukin-1 (IL-1) is a pro-inflammatory cytokine involved in aging-related inflammation.

Objective: We sought to determine whether IL-1 mediates aging-related changes in the heart, as seen in HFpEF.