Publications by authors named "Haakon H Sigurslid"
Article Synopsis
- Coronary artery calcification (CAC) is linked to heart disease and assessed through a genome-wide association study (GWAS) involving 22,400 participants from various backgrounds.
- The study confirmed connections with four known genetic loci and discovered two new loci related to CAC, with supportive replication findings for both.
- Functional tests suggest that ARSE promotes calcification in vascular smooth muscle cells and its variants may influence CAC levels, identifying ARSE as a key target for potential treatments in vascular calcific diseases.
Article Synopsis
- Arterial stiffness is identified as a risk factor for cardiovascular diseases, particularly heart failure with preserved ejection fraction (HFpEF), and circulating levels of inactive matrix Gla protein (ucMGP) are linked to these health issues.
- In a study analyzing data from the Framingham Heart Study, higher levels of ucMGP were associated with increased arterial stiffness and were predictive of future heart failure and rising blood pressure.
- Experimental studies in mice also showed that older Mgp mice exhibited increased arterial stiffness, supporting the notion that targeting MGP could be a potential therapeutic strategy for addressing HFpEF.
Article Synopsis
- The study aimed to identify risk factors for mechanical ventilation and in-hospital mortality in COVID-19 patients upon their admission to hospitals, using a cohort from Mass General Brigham hospitals.
- The researchers analyzed data from 1,042 patients and created two risk scores (VICE and DICE) based on specific predictors, achieving high accuracy in forecasting outcomes.
- Findings indicated that certain factors like diabetes and age were significant predictors of patient needs and mortality, with chronic statin use suggesting a protective effect against death from COVID-19.
Background: Risk stratification of COVID-19 patients upon hospital admission is key for their successful treatment and efficient utilization of hospital resources.
Objective: To evaluate the risk factors associated with ventilation need and mortality.
Design, Setting And Participants: We established a retrospective cohort of COVID-19 patients from Mass General Brigham hospitals.
Mortality rates of coronavirus disease-2019 (COVID-19) continue to rise across the world. Information regarding the predictors of mortality in patients with COVID-19 remains scarce. Herein, we performed a systematic review of published articles, from 1 January to 24 April 2020, to evaluate the risk factors associated with mortality in COVID-19.
View Article and Find Full Text PDFAtherosclerotic cardiovascular disease is a major burden on global health and a leading cause of death worldwide. The pathophysiology of this chronic disease is complex, involving inflammation, lipoprotein oxidation and accumulation, plaque formation, and calcification. In 1981, Dr.
View Article and Find Full Text PDFAortic calcification is an important independent predictor of future cardiovascular events. We performed a genome-wide association meta-analysis to determine SNPs associated with the extent of abdominal aortic calcification (n = 9,417) or descending thoracic aortic calcification (n = 8,422). Two genetic loci, HDAC9 and RAP1GAP, were associated with abdominal aortic calcification at a genome-wide level (P < 5.
View Article and Find Full Text PDFPotentiometric sensing of ions with ion-selective electrodes (ISEs) is a powerful technique for selective and sensitive measurement of ions in complex matrices. The application of ISEs is generally limited to laboratory settings, because most commercially available ISEs and reference electrodes are large, delicate, and expensive, and are not suitable for point-of-use or point-of-care measurements. This work utilizes cotton thread as a substrate for fabrication of robust and miniaturized ISEs that are suitable for point-of-care or point-of-use applications.
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