Publications by authors named "Haahr K"
Article Synopsis
- - This study explored how the age of men undergoing assisted reproductive technology (ART) affects factors like the day of blastocyst transfer, its stage, morphology, and the initial hCG rise related to achieving a live birth.
- - Analyzing data from 4842 couples, the results indicated that as men's age increases, there’s a 6% higher chance that the competent blastocyst is transferred on day 6 instead of day 5, particularly in controlled ovarian stimulation (COS) treatments.
- - The study suggests that older paternal age is linked to lower initial hCG levels, likely due to the increased time needed for oocytes to repair sperm DNA fragmentation, highlighting a potential area for future research in male reproductive
Study Question: Are transfer day, developmental stage and morphology of the competent blastocyst in pregnancies leading to live birth associated with preterm birth, birthweight, length at birth and sex of the child?
Summary Answer: A high score in blastocyst developmental stage and in trophectoderm (TE) showed a significant association with the sex of the child, while no other associations with obstetric outcomes were observed.
What Is Known Already: The association between blastocyst assessment scores and obstetric outcomes have been reported in small single-center studies and the results are conflicting.
Study Design, Size, Duration: Multicenter historical cohort study based on exposure data (transfer day (blastocyst developmental stage reached by Day 5 or Day 6)) blastocyst developmental stage (1-6) and morphology (TE and inner cell mass (ICM): A, B, C)) and outcome data (preterm birth, birthweight, length at birth, and sex of the child) from women undergoing single blastocyst transfer resulting in a singleton pregnancy and live birth.
Objective: To study if the age of women undergoing assisted reproductive technology treatment associates with stage, morphology, and implantation of the competent blastocyst.
Design: Multicenter historical cohort study based on exposure (age) and outcome data (blastocyst stage and morphology and initial human chorionic gonadotrophin [hCG] rise) from women undergoing single blastocyst transfer resulting in singleton pregnancy/birth.
Setting: Sixteen private and university-based facilities.
Background: Physiological changes during pregnancy may affect laboratory parameters. Reference values based on samples from non-pregnant women are not necessarily useful for clinical decisions during pregnancy. There is a need to establish reference values during pregnancy in order to recognize pathological conditions.
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