Immunopathological markers and cell types linked to COVID-19 symptom manifestation.

Background: Numerous studies have investigated the molecular properties that contribute to the symptoms of COVID-19, such as the virus's genetic makeup, its replication mechanisms, and how it interacts with host cells. However, identifying the immunopathological properties, such as the immune system's response, cytokine levels, and the presence of specific biomarkers, that are associated with the severity of the infection remains crucial for developing effective treatments and preventions.

Methods: We analyzed blood protein factor profiles from 420 individuals to identify features differentiating between test-negative healthy, asymptomatic, and symptomatic individuals using statistical comparison and the least absolute shrinkage and selection operator (i.

IL-7-primed bystander CD8 tumor-infiltrating lymphocytes optimize the antitumor efficacy of T cell engager immunotherapy.

Bispecific T cell engagers (TCEs) show promising clinical efficacy in blood tumors, but their application to solid tumors remains challenging. Here, we show that Fc-fused IL-7 (rhIL-7-hyFc) changes the intratumoral CD8 T cell landscape, enhancing the efficacy of TCE immunotherapy. rhIL-7-hyFc induces a dramatic increase in CD8 tumor-infiltrating lymphocytes (TILs) in various solid tumors, but the majority of these cells are PD-1-negative tumor non-responsive bystander T cells.

Studies on the corrosion resistance of reinforced steel in concrete with ground granulated blast-furnace slag--An overview.

The partial replacement of clinker, the main constituent of ordinary Portland cement by pozzolanic or latent hydraulic industrial by-products such as ground granulated blast furnace slag (GGBFS), effectively lowers the cost of cement by saving energy in the production process. It also reduces CO2 emissions from the cement plant and offers a low priced solution to the environmental problem of depositing industrial wastes. The utilization of GGBFS as partial replacement of Portland cement takes advantage of economic, technical and environmental benefits of this material.