Isolation and Characterization of Novel Huperzine-Producing Endophytic Fungi from Species.

Huperzine A (HupA) is an important drug for treating Alzheimer's disease (AD) and is primarily extracted from the (). Failures in the chemical synthesis of Hup and in vitro culture have put in danger of extinction, and there is a need for an extensive investigation of Hup from alternative perspectives. The aim of this study is to identify endophytic fungi that produce high Hup or simultaneously produce many types of Hup and have high genetic stability derived from other species as a source of materials for natural Hup production.