Publications by authors named "Ha Pham Ngoc Le"
A sublethal ischemic episode [termed preconditioning (PC)] protects neurons in the brain against a subsequent severe ischemic injury. This phenomenon is known as brain ischemic tolerance and has received much attention from researchers because of its robust neuroprotective effects. We have previously reported that PC activates astrocytes and subsequently upregulates P2X7 receptors, thereby leading to ischemic tolerance.
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- Researchers investigated how an anti-depressant called fluoxetine (FLX) impacts glial cells, particularly their release of ATP, which is important for brain communication.
- The study found that FLX enhances ATP release through a specific transporter (VNUT) in astrocytes, and this action is crucial for its anti-depressant effects.
- Furthermore, manipulating the levels of VNUT in astrocytes affected FLX's ability to alleviate depression, suggesting that targeting glial responses could be key in developing more effective treatments.