Co-stimulating the left vmPFC compensates for apathy after levodopa withdrawal in Parkinson's patients with STN DBS.

Introduction: Subthalamic nucleus deep brain stimulation (STN DBS) improves motor symptoms of Parkinson's disease (PD), but its effect on motivation is controversial. Apathy, the lack of motivation, commonly occurs in PD and is often exacerbated after surgery and its concomitant levodopa reduction. Apathy and reward processing are associated with the ventromedial prefrontal cortex (vmPFC), which standard targeting strategies avoid by targeting the dorsolateral STN.

Local neuroanatomical and tract-based proxies of optimal subcallosal cingulate deep brain stimulation.

Background: Deep brain stimulation of the subcallosal cingulate area (SCC-DBS) is a promising neuromodulatory therapy for treatment-resistant depression (TRD). Biomarkers of optimal target engagement are needed to guide surgical targeting and stimulation parameter selection and to reduce variance in clinical outcome.

Objective/hypothesis: We aimed to characterize the relationship between stimulation location, white matter tract engagement, and clinical outcome in a large (n = 60) TRD cohort treated with SCC-DBS.

Electrophysiological Responses to Rapidly-Presented Affective Stimuli Predict Individual Differences in Subsequent Attention.

We are constantly surrounded by a dynamically changing perceptual landscape that can influence our behavior even without our full conscious awareness. Emotional processing can have effects on subsequent attention, but there are mixed findings on whether it induces attentional enhancement or interference. The present study used a new multimodal approach to explain and predict such attentional effects based on individual differences in response to emotional stimuli.