Trust in scientists and their role in society across 68 countries.

Science is crucial for evidence-based decision-making. Public trust in scientists can help decision makers act on the basis of the best available evidence, especially during crises. However, in recent years the epistemic authority of science has been challenged, causing concerns about low public trust in scientists.

Perceptions of science, science communication, and climate change attitudes in 68 countries - the TISP dataset.

Science is integral to society because it can inform individual, government, corporate, and civil society decision-making on issues such as public health, new technologies or climate change. Yet, public distrust and populist sentiment challenge the relationship between science and society. To help researchers analyse the science-society nexus across different geographical and cultural contexts, we undertook a cross-sectional population survey resulting in a dataset of 71,922 participants in 68 countries.

Discovery of STX-721, a Covalent, Potent, and Highly Mutant-Selective EGFR/HER2 Exon20 Insertion Inhibitor for the Treatment of Non-Small Cell Lung Cancer.

After L858R and ex19del epidermal growth factor receptor (EGFR) mutations, ex20ins mutations are the third most common class of driver-mutations in non-small cell lung cancer (NSCLC). Unfortunately, first-, second-, and third-generation EGFR tyrosine kinase inhibitors (TKIs) are generally ineffective for ex20ins patients due to insufficient mutant activity and selectivity over wild-type EGFR, leading to dose-limiting toxicities. While significant advances in recent years have been made toward identifying potent EGFR ex20ins mutant inhibitors, mutant vs wild-type EGFR selectivity remains a significant challenge.

How does it end? Endpoints of boundaries lead to completion in macro-events.

While watching someone kicking a ball, missing moments of ball contact can be incorrectly identified as seen if the event is continued in a causal manner (i.e., the ball flying off).

Predictive alternating runs and random task-switching sequences produce dissociative switch costs in the Consonant-Vowel/Odd-Even task.

Task-switching is commonly used to investigate working memory and attentional control processes. The current study compares predictive versus non-predictive task-sequencing effects on task-switching performance. Participants completed four blocks of the Consonant-Vowel/Odd-Even (CVOE) task: Two single task pure blocks, a predictable switch block where task switching occurred every two trials, and a random switch block where switching was unpredictable.

Pay-to-Play: The Rising Cost of Subspecialty Conference Attendance for Surgical Residents.

Objective: Surgical society conferences play a vital role in academic medicine, offering exposure to subspecialties, networking, and research presentation opportunities for surgical residents. However, the rising costs of attendance pose financial challenges, potentially deterring participation. We aimed to assess changes in conference costs, travel policies, and expenses for general surgery residents in North Carolina (NC) and South Carolina (SC) general surgery residency programs.

Affordance norms for 2825 concrete nouns.

Objects are commonly described based on their relations to other objects (e.g., associations, semantic similarity, etc.

Singing Does Not Necessarily Improve Memory More Than Reading Aloud.

The refers to the finding that words read aloud are better remembered than words read silently. This finding is typically attributed to the presence of additional sensorimotor features appended to the memory trace by the act of reading aloud, which are not present for items read silently. Supporting this perspective, the production effect tends to be larger for singing (the ) than reading aloud, possibly due to the inclusion of further sensorimotor features (e.

Chromosome-Scale, De Novo, Phased Genome Assemblies of Three Australian Limes: , , and .

Huanglongbing (HLB) is a severe citrus disease worldwide. Wild Australian limes like , , and possess beneficial HLB resistance traits. Individual trees of the three taxa were extensively used in a breeding program for over a decade to introgress resistance traits into commercial-quality citrus germplasm.

The impact of presentation modes on mental rotation processing: a comparative analysis of eye movements and performance.

Mental rotation is the ability to rotate mental representations of objects in space. Shepard and Metzler's shape-matching tasks, frequently used to test mental rotation, involve presenting pictorial representations of 3D objects. This stimulus material has raised questions regarding the ecological validity of the test for mental rotation with actual visual 3D objects.

Disposable Gastrointestinal Scopes: A Systematic Review.

Objective: Endoscopes are an essential tool in the diagnosis, screening, and treatment of gastrointestinal diseases. In 2019, the Food and Drug Administration issued a news release, recommending that duodenoscope manufacturers and health care facilities phase out fully reusable duodenoscopes with fixed endcaps in lieu of duodenoscopes that are either fully disposable or those that contain disposable endcaps. With this study, we systematically reviewed the published literature on single-use disposable gastrointestinal scopes to describe the current state of the literature and provide summary recommendations on the role of disposable gastrointestinal endoscopes.

The drawing effect: Evidence for costs and benefits using pure and mixed lists.

Drawing a referent of a to-be-remembered word often results in better recognition and recall of this word relative to a control task in which the word is written, a pattern dubbed the drawing effect. Although this effect is not always found in pure lists, we report three experiments in which the drawing effect emerged in both pure- and mixed-lists on recognition and recall tests, though the effect was larger in mixed lists. Our experiments then compared drawing effects on memory between pure- and mixed-list contexts to determine whether the larger mixed-list drawing effect reflected a benefit to draw items, a cost to write items, or a combination.

Short-term transfer effects of Tetris on mental rotation: Review and registered report - A Bayesian approach.

The existence of transfer effects of video games on cognitive performance are controversially discussed in experimental psychology. Whereas recent meta-analyses suggest the absence of far transfer effects, empirical evidence regarding near transfer effects is more controversial. This conceptual replication investigated the short-term near transfer effect of playing Tetris on mental rotation abilities.

Construction or updating? Event model processes during visual narrative comprehension.

The plot of a narrative is represented in the form of event models in working memory. Because only parts of the plot are actually presented and information is continually changing, comprehenders have to infer a good portion of a narrative and keep their mental representation updated. Research has identified two related processes (e.

Examination of the Multilevel Sexual Stigma Model of Intimate Partner Violence Risk Among LGBQ+ College Students: A Prospective Analysis Across Eighteen Institutions of Higher Education.

Sexual stigma operates at multiple levels (institutional, group, individual), which serves to disadvantage sexual minority (LGBQ+) individuals and increases risk for deleterious outcomes. The current study evaluated a novel multilevel sexual stigma model of intimate partner violence (MLSSM-IPV) that incorporates multiple levels of sexual stigma as related to IPV risk via several pathways (e.g.

Intravascular large B-cell lymphoma masquerading as stroke successfully treated with R-Hyper-CVAD.

Intravascular large B cell lymphoma (IVLBCL) is exceedingly rare and difficult to diagnose. We describe a case of IVLBCL in a 56-year-old male which was identified after recurrent strokes. Right partial nephrectomy was then performed which demonstrated renal oncocytoma and IVLBCL.

Item-specific and relational encoding are effective at reducing the illusion of competence.

Metamemory, or the ability to understand the capacities of one's own memory, is important for learning. To investigate questions surrounding metamemory, researchers commonly have participants make judgments of learning (JOLs) at encoding, in which participants rate their likelihood of recalling the target in a cue-target word pair when shown only the cue at test. However, the associative direction of cue-target pairs can affect the calibration of JOLs.

Metacognition, public health compliance, and vaccination willingness.

Metacognition, our ability to reflect on our own beliefs, manifests itself in the confidence we have in these beliefs, and helps us guide our behavior in complex and uncertain environments. Here, we provide empirical tests of the importance of metacognition during the pandemic. Bayesian and frequentist analyses demonstrate that citizens with higher metacognitive sensitivity-where confidence differentiates correct from incorrect COVID-19 beliefs-reported higher willingness to vaccinate against COVID-19, and higher compliance with recommended public health measures.

Modal and amodal cognition: an overarching principle in various domains of psychology.

Accounting for how the human mind represents the internal and external world is a crucial feature of many theories of human cognition. Central to this question is the distinction between modal as opposed to amodal representational formats. It has often been assumed that one but not both of these two types of representations underlie processing in specific domains of cognition (e.

Online Interaction Turns the Congeniality Bias Into an Uncongeniality Bias.

Online phenomena like echo chambers and polarization are believed to be driven by humans' penchant to selectively expose themselves to attitudinally congenial content. However, if like-minded content were the only predictor of online behavior, heated debate and flaming on the Internet would hardly occur. Research has overlooked how online behavior changes when people are given an opportunity to reply to dissenters.

Past 6-Month Prevalence of IPV Victimization among Transgender and Gender-Diverse Undergraduate Students: A Brief Report.

Research has largely neglected the issue of intimate partner violence (IPV) among transgender and gender-diverse (TGD; e.g., nonbinary and genderqueer) individuals.

STX-478, a Mutant-Selective, Allosteric PI3Kα Inhibitor Spares Metabolic Dysfunction and Improves Therapeutic Response in PI3Kα-Mutant Xenografts.

Unlabelled: Phosphoinositide 3-kinase α (PIK3CA) is one of the most mutated genes across cancers, especially breast, gynecologic, and head and neck squamous cell carcinoma tumors. Mutations occur throughout the gene, but hotspot mutations in the helical and kinase domains predominate. The therapeutic benefit of isoform-selective PI3Kα inhibition was established with alpelisib, which displays equipotent activity against the wild-type and mutant enzyme.

Gender-neutral bathrooms on campus: a multicampus study of cisgender and transgender and gender diverse college students.

This study examined cisgender and transgender and gender diverse (TGD) college students' perceptions of gender-neutral bathroom availability across eight U.S. campuses, TGD students' fear of harassment related to (lack of) availability of gender-neutral bathrooms, and the relation between fear of harassment and TGD students' psychological distress.

Cultural Competence Guides for COVID-19 Messaging in Hispanic Communities.

Purpose: The Rio Grande Valley in South Texas comprises 5% percent of Texas's population yet 17%of Texas's COVID-19 deaths. We aimed to address underlying mistrust and systemic racism in our Hispanic community that contributes to health inequities by developing a cultural competence guide for public health messaging.

Methods: We employed a mixed method design (e.