Correlation between cardiometabolic index and female infertility: a cross-sectional analysis.

Background: Obesity and adverse lipid profile leads to female infertility. The cardiometabolic index (CMI) is a promising indicator for predicting obesity-related diseases. The correlation between CMI and female infertility merits further investigation.

A Multifunctional NaSe/Zn-Mn Skeleton Enables Processable and Highly Reversible Sodium Metal Anode.

The recent high-energy density sodium (Na) metal batteries (SMBs) are restricted by their processability, lifetime, and safety. These issues can be addressed by controlling the reactions at the Na metal by modifying the Na metal anode (SMA) with the sodiophilic hosts. Herein, a multifunctional NaSe/Zn-Mn skeleton is introduced for SMA and fabricate a processable Na@NaSe/Zn-Mn composite using repeated cold rolling/folding approach through the spontaneous reaction between Na metal and ZnMnSe alloy.

TSPO exacerbates sepsis-induced cardiac dysfunction by inhibiting p62-Mediated autophagic flux via the ROS-RIP1/RIP3-exosome axis.

Septic cardiomyopathy (SCM) is a critical complication of sepsis, primarily attributed to mitochondrial dysfunction and impaired autophagic flux. This study explores the role of translocator protein (TSPO) in SCM pathogenesis and assesses its potential as a therapeutic target. We identified increased TSPO expression in plasma samples from sepsis patients, with further validation in septic rats and LPS-stimulated H9C2 cardiomyocytes.

PM induces lung inflammation through ANGPTL4.

Fine particulate matter (PM) is a common major air pollutant associated with decreased lung function, induced allergic airway inflammation closely correlated with chronic lung diseases. Angiopoietin-like protein 4 (ANGPTL4) is a cytokine with multiple functions, participating in processes such as inflammation, angiogenesis, and metastasis. Curcumin is an active compound found in turmeric plants and possesses various pharmacological effects, including antioxidant, anti-inflammatory, anticancer, and immunomodulatory properties.

Crystalline Electrolyte Boosts High Performance of All-Solid-State Lithium-Ion Batteries.

The rigid solid-solid contact at the interface between the solid electrolyte and electrodes in full-solid-state lithium-ion batteries (ASSBs) presents a considerable challenge to lithium ion transport. To address this, we propose using Li-concentrated succinonitrile (Li-SN45) as an efficient bilateral interface modifier in ASSBs. This material boasts exceptional ionic conductivity of 3.

Weightlessness damaged the ultrastructure of knee cartilage and quadriceps muscle, aggravated the degeneration of cartilage.

Background: Long-term exposure to weightlessness can result in bone and muscle degradation, significantly impacting musculoskeletal function. Recent studies have also indicated damage to articular cartilage due to weightlessness. This study aims to observe the effects of simulated weightlessness on the cartilage microstructure of the quadriceps muscle and the muscular knee joint in rats.

Differential regulation of sleep by blue, green, and red light in .

Introduction: Exposure to blue-enriched light from electronic devices is an emergent disruptor of human sleep, especially at particular times of day. Further dissection of this phenomenon necessitates modeling in a tractable model organism.

Methods: Thus, we investigated the effects of light color on sleep in .

Distribution of Pathogenic Bacteria and Drug Resistance in ICU of a Newly Built Hospital.

Objective: This study investigated the distribution and resistance patterns of pathogens in the intensive care unit of a newly established hospital in Guizhou Province to promote the rational use of antibiotics to reduce multidrug resistance.

Methods: A retrospective analysis was conducted on the distribution of pathogens and changes in drug resistance in the ICU of a newly built hospital in Guizhou Province from March 2019 to December 2023. WHONET 5.

Task-switching mechanisms under methamphetamine cravings: sex differences in cued and voluntary task-switching.

Introduction: This study explored the effects of task-switching type and sex on the task-switching ability of methamphetamine abstainers, as well as the differences in brain mechanisms under drug cravings under drug cravings using near-infrared spectroscopy.

Methods: Craving-inducing videos were used to arouse 20 methamphetamine abstainers (including 10 men), whose switching ability was then assessed using voluntary and cued task-switching exercises.

Results: During task-switching under methamphetamine cravings, the activation of the premotor cortex (PMC), supplementary motor area (SMA), frontal eye field (FEF), and dorsolateral prefrontal cortex (DLPFC) in women was significantly stronger than in men, while the activation of FEF in men was significantly stronger than in women.

Global prevalence and pattern of injuries in basketball players: a systematic review.

Introduction: Basketball, as a widely popular sport, can be associated with a high risk of injury. This study aimed to provide a comprehensive overview of basketball-related injuries in various groups through the utilization of a systematic review methodology.

Evidence Acquisition: An extensive search was conducted in the four valid databases using three groups of keywords up to November 2023 based on the PRISMA guidance.

Coupling of photonic topological states and their dynamical control based on liquid crystal.

Optical field manipulation inspired by topology theory has recently drawn great research attention in nanophotonic. For flexible and programmable light management, the capacity to dynamically regulate the photonic topological states in fixed optical artificial microstructures is essential. Here, we propose a dynamic light manipulation of a two-dimensional (2D) photonic lattice aided by liquid crystals, which is composed of all-dielectric photonic crystals with distinct topological phases.

The combined effect of hypoxia activation and radiosensitization by a multifunctional nanoplatform system enhances the therapeutic efficacy of chemoradiotherapy in pancreatic cancer.

Background: Pancreatic cancer is a highly malignant tumor, which is still a major global health problem. Chemotherapy and radiotherapy are regularly used in adjuvant therapy for pancreatic cancer but their therapeutic efficacy is limited.

Methods: In the present study, nanoparticle（MSN-AuNPs） was used as a drug carrier loaded with tirapazamine(TPZ) and hyaluronic acid (HA) to synthesize a multifunctional nanoplatform HA@TPZ-MSN-AuNPs (HTMA) for hypoxia activation and radiotherapy sensitization, which can be combined with radiotherapy therapy and synergistically enhance the therapeutic effect in pancreatic cancer.

Association between residential greenness exposure and semen quality: A retrospective study in China.

Background: The association between greenness exposure and semen quality and the underlying mechanism are unclear.

Objectives: To assess the association between greenness exposure and semen quality and whether the association is mediated by air pollutant exposure.

Methods: We collected data from 10,273 men in Zhejiang, China, whose wives received assisted reproductive technology from 2015 to 2021.

Research on the second-harmonic focused ultrasonic device based on micro-bubble contrast agents.

Non-invasive, accurate diagnosis and treatment have increasingly gained attention in medical research. The nonlinear response mechanism of ultrasound contrast agents and their medical application have become major topics in ultrasound imaging studies. This paper reports on a second-harmonic focused ultrasonic device based on micro-bubble contrast agents, which is designed to solve the problems associated with a weak second-harmonic intensity.

TET2 regulates early and late transitions in exhausted CD8 T cell differentiation and limits CAR T cell function.

CD8 T cell exhaustion hampers control of cancer and chronic infections and limits chimeric antigen receptor (CAR) T cell efficacy. Targeting in CAR T cells provides therapeutic benefit; however, TET2's role in exhausted T cell (T) development is unclear. In chronic lymphocytic choriomeningitis virus (LCMV) infection, TET2 drove conversion from stem cell-like T progenitors toward terminally differentiated and effector (T)-like T.

Sintilimab Combined with Nanoparticle Albumin-Bound Paclitaxel-Based Chemotherapy in Severe Locally Advanced or Metastatic Squamous NSCLC Showed Good Efficacy and Safety: A Pilot Retrospective Analysis.

Introduction: Squamous non-small cell lung carcinoma (sqNSCLC) is associated with a poorer prognosis and limited treatment options. Sintilizumab combined with chemotherapy is used as first-line treatment for advanced sqNSCLC. However, the efficacy and safety of sintilimab combined with nanoparticle albumin-bound paclitaxel-based chemotherapy for severe squamous NSCLC remain to be unknown in clinical studies.

Association of Dietary Flavonoids Intake With All-Cause and Cardiovascular Disease Mortality in Diabetic Kidney Disease: A Cohort Study From the NHANES Database.

The relationship between dietary flavonoid intake and mortality in the diabetic kidney disease (DKD) population is unknown. So this study is aimed at investigating the association of total dietary flavonoid intake and their subclasses with all-cause and cardiovascular disease (CVD) mortality. Data of this cohort study were extracted from the NHANES (2007-2010 and 2017-2018).