Tuberculous meningitis-related ischemic stroke: A retrospective study from a tertiary care hospital.

Background: Patients with tuberculous meningitis (TBM) are at high risk of ischemic stroke, and stroke is a poor prognosticator of TBM. However, reports regarding the predictors of stroke in TBM patients are scanty. The aim of this study was to investigate the clinical characteristics and predictors of tuberculous meningitis-related ischemic stroke (TBMRIS).

Therapeutic potential of CD20/CD3 bispecific antibodies in the treatment of autoimmune diseases.

Autoimmune diseases arise from immune system dysfunction that immune cells mistakenly attack the body's own tissues, resulting in systemic disorders or localized lesions such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). Autoreactive B cells play a critical role in the pathogenesis of many autoimmune diseases and B cell depletion using anti-CD20 monoclonal antibody (mAb) has been shown to effectively mitigate disease progression in both preclinical and clinical studies. Recently, bispecific antibody (bsAb) targeting CD20/CD3 have demonstrated substantial clinical benefits in the treatment of various hematologic malignancies.

Bioinformatic identification of signature miRNAs associated with fetoplacental vascular dysfunction in gestational diabetes mellitus.

Background: Intrauterine exposure to gestational diabetes mellitus (GDM) poses significant risks to fetal development and future metabolic health. Despite its clinical importance, the role of microRNAs (miRNAs) in fetoplacental vascular endothelial cell (VEC) programming in the context of GDM remains elusive. This study aims to identify signature miRNA genes involved in this process using bioinformatics analysis via multiple algorithms.

EUS-guided fine-needle biopsy fine-needle aspiration for histopathological evidence for type 1 autoimmune pancreatitis: A single-center retrospective study in China.

Background And Objectives: EUS is recommended for guiding pancreatic tissue acquisition in suspected autoimmune pancreatitis (AIP) cases. However, there is a lack of comparative research on the effectiveness between EUS-guided fine-needle aspiration (EUS-FNA) and EUS-guided fine-needle biopsy (EUS-FNB) for diagnosing AIP in China. This study aimed to evaluate the diagnostic accuracy of EUS-guided tissue acquisition (EUS-TA) specifically for type 1 AIP.

Study on the mechanical properties and failure mechanism of a multi-lithologic layered rock mass.

The mechanical properties of multi-lithologic reservoir rock masses are complex, and the failure mechanism is not clear. This research belongs to the field of oil and gas exploration and development. Brazilian splitting, and digital image correlation (DIC) tests were performed to study the mechanical properties and failure mechanism of assemblages containing sandstone, shale, and limestone.

MHCI trafficking signal-based mRNA vaccines strengthening immune protection against RNA viruses.

The major histocompatibility complex class I (MHCI) trafficking signal (MITD) plays a pivotal role in enhancing the efficacy of mRNA vaccines. However, there was a lack of research investigating its efficacy in enhancing immune responses to RNA virus infections. Here, we have developed an innovative strategy for the formulation of mRNA vaccines.

Mitigating the Efficiency Deficit in Single-Crystal Perovskite Solar Cells by Precise Control of the Growth Processes.

The power conversion efficiencies (PCEs) of polycrystalline perovskite solar cells (PC-PSCs) have now reached a plateau after a decade of rapid development, leaving a distinct gap from their Shockley-Queisser limit. To continuously mitigate the PCE deficit, nonradiative carrier losses resulting from defects should be further optimized. Single-crystal perovskites are considered an ideal platform to study the efficiency limit of perovskite solar cells due to their intrinsically low defect density, as demonstrated in bulk single crystals.

High Energy Storage Under the Regulation of Polymer Phase Structure.

Dielectric nanocomposites have garnered significant interest owing to their potential applications in energy storage. However, achieving high energy density (U) and charge/discharge efficiency (η) remains a challenge in their fabrication. In this paper, core-shell structured BaTiO@Polyvinylpyrrolidone (BT@PVP) nanoparticles are prepared, and incorporated into a semi-crystalline polyvinylidene fluoride (PVDF) matrix.

5β-hydroxycostic acid from Laggera alata ameliorates sepsis-associated acute kidney injury through its anti-inflammatory and anti-ferroptosis effects via NF-κB and MAPK pathways.

Ethnopharmacological Relevance: The whole plant of Laggera alata is frequently utilize to remedy inflammatory diseases including nephritis as a traditional Chinese medicine. However, its active ingredients and mechanism of action against sepsis-associated acute kidney injury (SA-AKI) are unknown.

Aim Of The Study: This study aimed to identify active compounds from L.

Interventions to Reduce Loneliness Among Community-dwelling Older Adults: A Network Meta-analysis and Systematic Review.

Objectives: This study aimed to evaluate the effectiveness of interventions in reducing loneliness among community-dwelling older adults.

Design: A network meta-analysis (NMA) and systematic review.

Setting And Participants: Interventional studies were included if they contained original quantitative data on interventions to reduce loneliness among community-dwelling older adults.

Evaluation of sticky bone in guided bone regeneration in the aesthetic area of the anterior teeth: a retrospective study.

The retrospective study aimed to compare the space-maintaining effects of sticky bone (bone graft matrix enriched with injectable platelet-rich fibrin) and titanium mesh for bone augmentation in the aesthetic zone. Patients who underwent single implant placement and had type 2/4 alveolar bone defects (buccal bone wall loss is >50% of the expected implant length) were screened for inclusion in this study. The labial bone plate width was measured at 1, 3, and 5 mm below the apical implant platform on cone beam computed tomography images taken immediately and 6 months after surgery.

Possible role of autophagy in microbial volatile pollutant-induced starch degradation and expression of hypoxia responsive genes.

Autophagy is thought to be critically involved in the regulation of nutrient metabolism and gene expression. Nevertheless, little is known about its role in regulating starch metabolism and hypoxia responsive genes in plants exposed to microbial volatile pollutants. In the present study, we found that exposure of Arabidopsis to Enterobacter aerogene (E.

GFA-Net: Geometry-Focused Attention Network for Six Degrees of Freedom Object Pose Estimation.

Six degrees of freedom (6-DoF) object pose estimation is essential for robotic grasping and autonomous driving. While estimating pose from a single RGB image is highly desirable for real-world applications, it presents significant challenges. Many approaches incorporate supplementary information, such as depth data, to derive valuable geometric characteristics.

Multi-Band Scattering Characteristics of Miniature Masson Pine Canopy Based on Microwave Anechoic Chamber Measurement.

Using microwave remote sensing to invert forest parameters requires clear canopy scattering characteristics, which can be intuitively investigated through scattering measurements. However, there are very few ground-based measurements on forest branches, needles, and canopies. In this study, a quantitative analysis of the canopy branches, needles, and ground contribution of Masson pine scenes in C-, X-, and Ku-bands was conducted based on a microwave anechoic chamber measurement platform.

Correction: Tian et al. Genome-Wide Identification of the DnaJ Gene Family in Citrus and Functional Characterization of in Response to Citrus Huanglongbing. 2024, , 11967.

In the original publication [...

Integrative Targeted Metabolomics and Transcriptomics Reveal the Mechanism of Leaf Coloration in 'Sakimp005'.

One of the most important characteristics of ornamental plants is leaf color, which enhances the color of plant landscapes and attracts pollinators for reproduction. The leaves of 'Sakimp005' are initially green, then the middle part appears yellow, then gradually become white, while the edge remains green. In the study, leaves of 'Sakimp005', in four developmental stages (S1-G, S2-C, S3-C, and S4-C), were selected for the determination of pigment content, chromaticity values, integrative metabolomics, and transcriptomics analyses.

Advances in Surface-Enhanced Raman Spectroscopy for Therapeutic Drug Monitoring.

Therapeutic drug monitoring (TDM) is pivotal for optimizing drug dosage regimens in individual patients, particularly for drugs with a narrow therapeutic index. Surface-enhanced Raman spectroscopy (SERS) has shown great potential in TDM due to high sensitivity, non-destructive analysis, specific fingerprint spectrum, low sample consumption, simple operation, and low ongoing costs. Due to the rapid development of SERS for TDM, a review focusing on the analytical method is presented to better understand the trends.

Higher dietary zinc intake increases the risk of autoimmune thyroiditis.

Background: Autoimmune thyroiditis (AIT), encompassing Hashimoto's thyroiditis (HT), is a prevalent chronic autoimmune disorder characterized by lymphocytic infiltration and the presence of anti-thyroid antibodies. It is the primary cause of primary hypothyroidism and affects women more frequently than men. Nearly 95% of individuals with HT exhibit thyroid peroxidase antibodies or thyroglobulin antibodies.

UVB Induces Sympathetic Nervous System Activation and Norepinephrine Secretion to Regulate The Skin Color of Mice Through the β2-AR/AP-1 Pathway in Epidermal Keratinocytes.

The aim of this study was to investigate how ultraviolet B (UVB) light regulates AP-1 expression via the β2-adrenergic receptor (β2-AR) in epidermal keratinocytes, which in turn regulates melanin synthesis in melanocytes, thereby modulating downstream melanin production in skin hair follicles and altering mouse skin color. We established a UV-irradiated mouse model to investigate the effects of UV radiation on changes in skin color. By measuring changes in the expression of genes related to cutaneous sympathetic nerves, norepinephrine synthesis and melanin synthesis, we investigated the relationship between β2-AR expression and cutaneous melanogenesis and determined the localization of β2-AR in cells.

Structure and catalytic mechanism of exogenous fatty acid recycling by AasS, a versatile acyl-ACP synthetase.

Fatty acids (FAs) are essential building blocks for all the domains of life, of which bacterial de novo synthesis, called type II FA synthesis (FAS II), is energetically expensive. The recycling of exogenous FAs (eFAs) partially relieves the FAS II demand and, therefore, compromises the efficacy of FAS II-directed antimicrobials. The versatile acyl-acyl carrier protein (ACP) synthetase, AasS, enables bacterial channeling of diverse eFA nutrients through holo-ACP, an activated form of ACP.

Establishing the Link Between Oxygen Vacancy and Activity Enhancement in Acidic Water Oxidation of Trigonal Iridium Oxide.

Developing durable IrO-based electrocatalysts with high oxygen evolution reaction (OER) activity under acidic condition is crucial for proton exchange membrane electrolyzers. While oxygen defects are considered potentially important in OER, their direct relationship with catalytic activity has yet to be established. In this study, we introduced abundant oxygen vacancies through Re doping in 2D IrO (ReIrO), demonstrating their decisive role in enhancing OER performance.

Fusion of FDG and FMZ PET Reduces False Positive in Predicting Epileptogenic Zone.

Background And Purpose: Epilepsy, a globally prevalent neurological disorder, necessitates precise identification of the epileptogenic zone (EZ) for effective surgical management. While the individual utilities of FDG PET and FMZ PET have been demonstrated, their combined efficacy in localizing the epileptogenic zone remains underexplored. We aim to improve the non-invasive prediction of epileptogenic zone (EZ) in temporal lobe epilepsy (TLE) by combining FDG PET and FMZ PET with statistical feature extraction and machine learning.

Introduction of the single-lumen oocyte retrieval needle in an assisted reproductive technology center: Propensity score matching analysis of grouping.

Objective: To evaluate the effectiveness of oocyte retrieval using a single-lumen aspiration needle compared to a double-lumen aspiration needle in IVF (in vitro fertilization) patients.

Materials And Methods: This retrospective cohort study included all IVF cycles between 1st January, 2020 and 31st December, 2022 in Changhua Christian Hospital, Taiwan. Pairwise comparisons were conducted through propensity score matching analysis at a 1:3 ratio according to patients' age, anti-Müllerian hormone levels, and body weight.

Construction of non-noble decorated Z-scheme Bi-BiVO-BiTiO for enhanced full solar-spectrum driven photocatalytic activity.

Currently, to deal with the increasingly severe energy crisis and environmental consequences, photocatalytic technology is considered as a promise solution, and the construction of Z-scheme heterostructures are important strategies to maximize the utilization of solar energy and improve photocatalytic performance. Herein, a novel full spectrum-responsive Z-scheme Bi-BiVO-BiTiO heterojunction was constructed by a facile hydrothermal method without any templates or surfactants. A series of detailed analyses revealed that the novel Bi-BiVO-BiTiO heterojunction catalyst were prepared successfully.

CD70-targeted iPSC-derived CAR-NK cells display potent function against tumors and alloreactive T cells.

Clinical application of autologous chimeric antigen receptor (CAR)-T cells is complicated by limited targeting of cancer types, as well as the time-consuming and costly manufacturing process. We develop CD70-targeted, induced pluripotent stem cell-derived CAR-natural killer (NK) (70CAR-iNK) cells as an approach for universal immune cell therapy. Besides the CD70-targeted CAR molecule, 70CAR-iNK cells are modified with CD70 gene knockout, a high-affinity non-cleavable CD16 (hnCD16), and an interleukin (IL)-15 receptor α/IL-15 fusion protein (IL15RF).