HO Triggering Electron-Directed Transfer of Emerging Contaminants over Asymmetric Nano Zinc Oxide Surfaces for Water Self-Purification Expansion.

Slow mass transfer processes between inert emerging contaminants (ECs) and dissolved oxygen (DO) limit natural water self-purification; thus, excessive energy consumption is necessary to achieve ECs removal, which has become a longstanding global challenge. Here, we propose an innovative water self-purification expansion strategy by constructing asymmetric surfaces that could modulate trace HO as trigger rather than oxidant to bridge a channel between inert ECs and natural dissolved oxygen, achieved through a dual-reaction-center (DRC) catalyst consisting of Cu/Co lattice-substituted ZnO nanorods (CCZO-NRs). During water purification, the bond lengths of emerging contaminants (ECs) adsorbed on the asymmetric surface were stretched, and this stretching was further enhanced by HO mediation, resulting in a significant reduction of bond-breaking energy barriers.

Hybridized triboelectric nanogenerators for simultaneously scavenging droplet and wind energies.

Triboelectric nanogenerators (TENGs) have attracted great attention due to the simple manufacturing process, low cost, and diverse forms of energy harvesting. However, the energy collected by individual TENG is relatively limited, making it necessary to develop new method to enhance the energy harvesting capability of TENG. Here, we design a hybridized TENG that integrates a droplet-driven TENG and a wind-driven TENG, which exhibits excellent electrical performance.

Circulating tumour cell clusters: isolation, biological significance and therapeutic implications.

Circulating tumour cells (CTCs) and CTC clusters are considered metastatic precursors due to their ability to seed distant metastasis. However, navigating the bloodstream presents a significant challenge for CTCs, as they must endure fluid shear forces and resist detachment-induced anoikis. Consequently, while a large number of cells from the primary tumour may enter the circulation, only a tiny fraction will result in metastasis.

Chryxanthone A, an extracted substance from endophytic fungal Aspergillus versicolor, produces anti-oxidant neuroprotection possibly via the action on mTOR/CREB axis.

Background: Neurons are susceptible to oxidative stress due to the elevated reactive oxygen species (ROS) production and the limited antioxidant defense mechanisms. Therefore, it is possible to treat oxidative stress-related neurological disorders via the inhibition of oxidative stress. Chryxanthone A is an extracted substance derived from the endophytic fungal Aspergillus versicolor, with an atypical dihydropyran ring.

16S rRNA and metabolomics reveal the key microbes and key metabolites that regulate diarrhea in Holstein male calves.

Introduction: Diarrhea is a prevalent disease among calves, which significantly hinders their growth and development, thereby impacting farm productivity and revenue. This study aimed to investigate the impact of diarrhea on calf growth.

Methods: Holstein male calves with similar birth weight (39.

Taxonomic notes on the genus Yoshida, 2007 (Araneae, Theridiidae) from China, with two new species.

Four species are reported from Hubei Province, China, including two new species: R. Zhong, J. Liu & Hu, (♂) and R.

MRI-based deep learning radiomics to differentiate dual-phenotype hepatocellular carcinoma from HCC and intrahepatic cholangiocarcinoma: a multicenter study.

Objectives: To develop and validate radiomics and deep learning models based on contrast-enhanced MRI (CE-MRI) for differentiating dual-phenotype hepatocellular carcinoma (DPHCC) from HCC and intrahepatic cholangiocarcinoma (ICC).

Methods: Our study consisted of 381 patients from four centers with 138 HCCs, 122 DPHCCs, and 121 ICCs (244 for training and 62 for internal tests, centers 1 and 2; 75 for external tests, centers 3 and 4). Radiomics, deep transfer learning (DTL), and fusion models based on CE-MRI were established for differential diagnosis, respectively, and their diagnostic performances were compared using the confusion matrix and area under the receiver operating characteristic (ROC) curve (AUC).

3D-AttenNet model can predict clinically significant prostate cancer in PI-RADS category 3 patients: a retrospective multicenter study.

Purposes: The presence of clinically significant prostate cancer (csPCa) is equivocal for patients with prostate imaging reporting and data system (PI-RADS) category 3. We aim to develop deep learning models for re-stratify risks in PI-RADS category 3 patients.

Methods: This retrospective study included a bi-parametric MRI of 1567 consecutive male patients from six centers (Centers 1-6) between Jan 2015 and Dec 2020.

Drainage from intentional extramacular holes after internal limiting membrane insertion to treat macular hole retinal detachment in highly myopic eyes.

Purpose: The purpose is to evaluate the effect of drainage from intentional extramacular holes after internal limiting membrane insertion to treat macular hole retinal detachment (MHRD) in highly myopic eyes.

Methods: This study is a retrospective, observational, and comparative case series that included 25 consecutive highly myopic eyes with MHRD. All eyes underwent standard 23-gauge vitrectomy, inverted internal limiting membrane insertion into the macular hole, subretinal fluid drainage from an intentionally created extramacular retinal hole, and tamponade with either silicone oil (SO group, n = 13) or perfluoropropane (CF group, n = 12).

Listening to the voices of adolescents with inflammatory bowel disease after returning to school: a qualitative study.

Background: The prevalence of inflammatory bowel disease (IBD) among Chinese adolescents has continued to increase in recent years. Adolescents with IBD interrupted their schooling due to the diagnosis and treatment of the disease. And when the condition stabilises, they will return to school.

Construction of hierarchically porous covalent organic frameworks with enhanced enzyme accessibility for sensitive dopamine detection.

Immobilization of fragile enzymes is vital to expanding its application in the extracellular environment. Covalent organic frameworks (COFs), as a class of emerging porous materials, are promising platforms for enzyme immobilization owing to their high porosity and tunable structure. However, the interior pores of COFs often fail to play their roles because of inaccessibility, resulting in decreased performance of immobilized enzymes.

Traditional Chinese medicine Chaiqinchengqi decoction for patients with acute pancreatitis: A randomized clinical trial.

Background: Chaiqinchengqi decoction, a traditional Chinese medicine, has shown promising effects in in vitro, animal and preliminary small human studies for acute pancreatitis, but evidence of clinical practice is limited.

Purpose: To investigate whether Chaiqinchengqi decoction could improve clinical outcomes in patients with acute pancreatitis.

Study Design: Prospective, pragmatic, randomized controlled trial.

Regulatory T Cells for Stroke Recovery: A Promising Immune Therapeutic Strategy.

Background: Stroke remains a leading cause of mortality and disability among adults. Given the restricted therapeutic window for intravascular interventions and neuroprotection during the acute phase, there has been a growing focus on tissue repair and functional recovery in the subacute and chronic phases after stroke. The pro-inflammatory microglial polarization occurs in subacute and chronic phases after stroke and may represent therapeutic targets for stroke recovery.

Establishment and validation of a nomogram for coronary artery lesions in children with Kawasaki disease.

Background: The nomogram is a powerful and robust tool in disease risk prediction that summarizes complex variables into a visual model that is interpretable with a quantified risk probability. In the current study, a nomogram was developed to predict the occurrence of coronary artery lesions (CALs) among patients with Kawasaki disease (KD). This is especially valuable in the early identification of the risk of CALs, which will lead to proper diagnosis and treatment to reduce their associated complications.

Data-driven and model-guided iterative reconstruction framework for simultaneous sparse-view and ring artifact reduction in synchrotron X-ray microtomography.

Synchrotron X-ray microtomography (S-µCT) is a highly valuable technique for investigating organ function and pathologies. However, its application is often limited by high radiation doses and the occurrence of ring artifacts. While S-µCT utilizing sparse-view projections can effectively decrease radiation doses, the reconstructed images frequently exhibit severe streaking artifacts, which are exacerbated by ring artifacts, ultimately compromising reconstruction accuracy, image quality, and resolution.

LncRNA-ANRIL regulates CDKN2A to promote malignant proliferation of Kasumi-1 cells.

Objective: This study aimed to investigate the regulatory effects of long non-coding RNA-ANRIL on CDKN2A in the cell cycle of Kasumi-1 cells and elucidate the underlying molecular mechanisms.

Methods: ANRIL and CDKN2A expression levels were quantified using RT-qPCR in peripheral blood samples from acute myeloid leukemia (AML) patients. CDKN2A knockdown efficiency was validated via RT-qPCR, and cell cycle distribution was analyzed using flow cytometry.

Revising the coal mining CH emission factor based on multiple inventories and atmospheric inversion approach at one of the world's largest coal production areas: Shanxi province, China.

Methane (CH) emissions from the coal industry represent a substantial portion of anthropogenic CH emissions from energy-related activities. China ranks as the world's largest coal producer, where Shanxi Province is one of its major coal production regions and accounts for 20.7 % of the national total coal production.

Low folate biomarker concentrations are associated with increase the risk and severity of periodontitis in adults: A cross-sectional study based on the National Health and Nutrition Examination Survey 2009-2014.

We sought to test the hypothesis that adult folate biomarker concentrations are negatively associated with the risk and severity of periodontitis. Data were pooled from the National Health and Nutrition Examination Survey (NHANES) 2009 to 2014. A total of 9252 dentate adult subjects aged 30 years and older who received a periodontal examination and had complete folate biomarker data were included in the analysis.

Dual oxygen supply system of carbon dot-loaded microbubbles with acoustic cavitation for enhanced sonodynamic therapy in diabetic wound healing.

Diabetic wounds present significant treatment challenges due to their complex microenvironment, marked by persistent inflammation from bacterial infections, hypoxia caused by diabetic microangiopathy, and biofilm colonization. Sonodynamic therapy (SDT) offers potential for treating such wounds by targeting deep tissues with antibacterial effects, but its efficacy is limited by hypoxic conditions and biofilm barriers. To overcome these obstacles, we developed a novel approach using oxygen-carrying microbubbles loaded with Mn-doped carbon dots (MnCDs@OMBs) to enhance SDT and disrupt biofilms.

Transthyretin variants impact blood-nerve barrier and neuroinflammation in amyloidotic neuropathy.

Hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) is a neurodegenerative disease caused by mutations in the gene encoding transthyretin (TTR). Despite amyloid deposition being pathognomonic for diagnosis, this pathology in nervous tissues cannot fully account for nerve degeneration, implying additional pathophysiology for neurodegeneration, which, however, has not yet been fully elucidated. In this study, neuroinflammation in ATTRv-PN was investigated by examining nerve morphometry, the blood-nerve barrier, and macrophage infiltration in the sural nerves of ATTRv-PN patients and the sciatic nerves of a complementary mouse system, i.

MAIT Cell-Mediated Immune Mechanisms of Dialysis-Induced Peritoneal Fibrosis and Therapeutic Targeting.

Background: Peritoneal fibrosis is a serious complication of long-term peritoneal dialysis (PD) and abdominal surgeries, yet effective treatments remain elusive. Given the known roles of mucosal-associated invariant T (MAIT) cells in immune responses and fibrotic diseases, we investigated their involvement in PD-induced peritoneal fibrosis to identify potential therapeutic targets.

Methods: We employed single-cell RNA sequencing (scRNA-seq) and flow cytometry to characterize the activation and function of peritoneal MAIT cells in patients undergoing long-term PD.

Chrysanthemum extract mitigates high-fat diet-induced inflammation, intestinal barrier damage and gut microbiota disorder.

An effective intervention for obesity without side effects is needed. Chrysanthemum may be the preferred choice due to its influence in the improvement of glycolipid metabolism. This study assessed the efficacy of chrysanthemum and its flavonoids in mitigating high-fat diet (HFD) induced obesity, focusing on the integrity of the intestinal barrier, inflammation, and gut microbiota.

CIDEC/FSP27 exacerbates obesity-related abdominal aortic aneurysm by promoting perivascular adipose tissue inflammation.

Abdominal aortic aneurysm (AAA) is strongly correlated with obesity, partially due to the abnormal expansion of abdominal perivascular adipose tissue (PVAT). Cell death-inducing DNA fragmentation factor-like effector C (CIDEC), also known as fat-specific protein 27 (FSP27) in rodents, is specifically expressed in adipose tissue where it mediates lipid droplet fusion and adipose tissue expansion. Whether and how CIDEC/FSP27 plays a role in AAA pathology remains elusive.

Exploring age and gender disparities in cardiometabolic phenotypes and lipidomic signatures among Chinese adults: a nationwide cohort study.

Understanding sex disparities in modifiable risk factors across the lifespan is essential for crafting individualized intervention strategies. We aim to investigate age-related sex disparity in cardiometabolic phenotypes in a large nationwide Chinese cohort. A total of 254,670 adults aged 40 years or older were selected from a population-based cohort in China.

Ultraprecision multi-axis CARIC control strategy with application to a nano-accuracy air-bearing motion stage.

Multi-axis contouring control is crucial for ultraprecision manufacturing industries, contributing to meeting the ever-increasingly stringent performance requirements. In this article, a novel contouring adaptive real-time iterative compensation (CARIC) method is proposed to achieve extreme multi-axis contouring accuracy, remarkable trajectory generalization, disturbance rejection, and parametric adaptation simultaneously. Specifically, control actions generated by CARIC consist of robust feedback, adaptive feedforward, and online trajectory compensation components.