Nuclear Structure of Dripline Nuclei Elucidated through Precision Mass Measurements of ^{23}Si, ^{26}P, ^{27,28}S, and ^{31}Ar.

Using the Bρ-defined isochronous mass spectrometry technique, we report the first determination of the ^{23}Si, ^{26}P, ^{27}S, and ^{31}Ar masses and improve the precision of the ^{28}S mass by a factor of 11. Our measurements confirm that these isotopes are bound and fix the location of the proton dripline in P, S, and Ar. We find that the mirror energy differences of the mirror-nuclei pairs ^{26}P-^{26}Na, ^{27}P-^{27}Mg, ^{27}S-^{27}Na, ^{28}S-^{28}Mg, and ^{31}Ar-^{31}Al deviate significantly from the values predicted assuming mirror symmetry.

Comparative Study on the Electrocatalytic Performance of ABO-Based Hexagonal Perovskite Oxides with Different [AO] Layers.

To systematically investigate the influence of the number of [AO] layers in the unit cell of hexagonal perovskite oxide on the oxygen evolution reaction performance, we successfully synthesized the three new hexagonal perovskite oxides 2H-BaCoRuO, 6H-BaCoRuO, and 10H-BaCoRuO with the same element composition but different [BaO] layers via the sol-gel method. Here, 2H, 6H, and 10H refer to the number of [BaO] layers contained in the unit cell of the BaCoRuO system. Experimentally, 10H-BaCoRuO, featuring ten layers of [BaO], exhibits optimal electrochemical activity among the three oxide catalysts, and in situ Raman results under various bias voltages confirm its ability to maintain a high surface crystal structural stability.

Methionine restriction promotes the polarization of macrophages towards M1 and the immunotherapy effect of PD-L1/PD-1 blockades by inhibiting the secretion of MIF by gastric carcinoma cells.

Background: The limited curative effect of PD-L1/PD-1 blockades presents challenges to immunotherapy for advanced gastric cancer. We have found that methionine restriction (MR) enhances the drug resistance of gastric carcinoma cells. We aimed to explore whether MR can enhance the efficacy of PD-L1/PD-1 blockades in gastric cancer.

Methionine restriction promotes cisplatin sensitivity of gastric cancer resistant cells by down-regulating circ-CDK13 level.

Background: Methionine restriction (MR) is a research direction in the treatment of gastric cancer (GC). The aim of this study was to investigate the molecular mechanism of MR on enhancing cisplatin (DDP) sensitivity of drug-resistant GC cells.

Methods: Twenty pairs of GC tissues and adjacent normal gastric mucosa tissues were collected.

Multipocket Cage Enables the Binding of High-Order Bulky and Drug Guests Uncovered by MS Methodology.

Achieving high guest loading and multiguest-binding capacity holds crucial significance for advancement in separation, catalysis, and drug delivery with synthetic receptors; however, it remains a challenging bottleneck in characterization of high-stoichiometry guest-binding events. Herein, we describe a large-sized coordination cage (MOC-70-ZnPd) possessing 12 peripheral pockets capable of accommodating multiple guests and a high-resolution electrospray ionization mass spectrometry (HR-ESI-MS)-based method to understand the solution host-guest chemistry. A diverse range of bulky guests, varying from drug molecules to rigid fullerenes as well as flexible host molecules of crown ethers and calixarenes, could be loaded into open pockets with high capacities.

Stereochemical Control of Redox Co/Co-Cages with Switchable Cotton Effects Based on Labile-Static States.

The structural dynamics of artificial assemblies, in aspects such as molecular recognition and structural transformation, provide us with a blueprint to achieve bioinspired applications. Here, we describe the assembly of redox-switchable chiral metal-organic cages Λ/Δ-[Pd(CoL)] and Λ/Δ-[Pd(CoL)]. These isomeric cages demonstrate an on-off chirality logic gate controlled by their chemical and stereostructural dynamics tunable through redox transitions between the labile Co-state and static Co-state with a distinct Cotton effect.

Study on Water Splitting of the 214-Type Perovskite Oxides LnSrCoO (Ln = La, Pr, Sm, Eu, and Ga).

We present a study on the electrocatalysis of 214-type perovskite oxides LnSrCoO (Ln = La, Pr, Sm, Eu, and Ga) with semiconducting-like behavior synthesized using the sol-gel method. Among these five catalysts, PrSrCoO exhibits the optimal electrochemical performance in both the oxygen evolution reaction and the hydrogen evolution reaction, mainly due to its larger electrical conductivity, mass activity, and turnover frequency. Importantly, the weak dependency of LSV curves in a KOH solution with different pH values, revealing the adsorbate evolving mechanism in PrSrCoO, and the density functional theory (DFT) calculations indicate that PrSrCoO has a smaller Gibbs free energy and a higher density of states near the Fermi level, which accelerates the electrochemical water splitting.

Edge State, Band Topology, and Time Boundary Effect in the Fine-Grained Categorization of Chern Insulators.

We predict novel topological phases with broken time-reversal symmetry supporting the coexistence of opposite chiral edge states, which are fundamentally different from the photonic spin-Hall, valley-Hall, and higher-order topological phases. We find a fine-grained categorization of Chern insulators, their band topologies characterized by identical Chern numbers are completely different. Furthermore, we prove that different topologies cause zeros in their Bloch wave function overlaps, which imprint the band gap closing and appear at the degenerate points of topological phase transition.

Discovery of New Isotopes ^{160}Os and ^{156}W: Revealing Enhanced Stability of the N=82 Shell Closure on the Neutron-Deficient Side.

Using the fusion-evaporation reaction ^{106}Cd(^{58}Ni,4n)^{160}Os and the gas-filled recoil separator SHANS, two new isotopes _{76}^{160}Os and _{74}^{156}W have been identified. The α decay of ^{160}Os, measured with an α-particle energy of 7080(26) keV and a half-life of 201_{-37}^{+58}  μs, is assigned to originate from the ground state. The daughter nucleus ^{156}W is a β^{+} emitter with a half-life of 291_{-61}^{+86}  ms.

Ion-Conductive Metallo-Covalent Organic Frameworks Constructed with Tridentate Ligand and Zn Nodes.

Metallo-covalent organic frameworks (metallo-COFs) are organometallic scaffolds in which covalently bonded organic frameworks are interwoven with metal-coordinated pendant groups. Unlike the rigid ligands traditionally used for metal coordination, the utilization of "soft" ligands allows for configurable topology and pore structure in metallo-COFs, particularly when the ligands are generated in situ during dynamic synthesis. In this study, we present the rational synthesis of metallo-COFs based on pyridine-2,6-diimine (pdi), wherein the incorporation of Zn ions and in situ-generated tridentate ligands (pdi) yields metallo-COFs with a square-like lattice.

Chronic exposure to nanocellulose altered depression-related behaviors in mice on a western diet: The role of immune modulation and the gut microbiome.

Aims: To determine if cellulose nanofibrils (CNF) have potential applications as food additives.

Materials And Methods: Male C57BL/6 mice on a Western diet were exposed to CNF for one month at a dose of 30 mg/kg by gavage. Male NOD mice, a model for type 1 diabetes (T1D), were used in a six-month study.

Dynamic Stereochemistry of M Pd Supramolecular Cages Based on Metal-Center Lability for Differential Chiral Induction, Resolution, and Recognition.

A series of isostructural supramolecular cages with a rhombic dodecahedron shape have been assembled with distinct metal-coordination lability (M Pd -MOC-16, M=Ru , Fe , Ni , Zn ). The chirality transfer between metal centers generally imposes homochirality on individual cages to enable solvent-dependent spontaneous resolution of Δ /Λ -M Pd enantiomers; however, their distinguishable stereochemical dynamics manifests differential chiral phenomena governed by the cage stability following the order Ru Pd >Ni Pd >Fe Pd >Zn Pd . The highly labile Zn centers endow the Zn Pd cage with conformational flexibility and deformation, enabling intrigue chiral-Δ /Λ -Zn Pd to meso-Δ Λ -Zn Pd transition induced by anions.

Dynamic Metallosupramolecular Cages Containing 12 Adaptable Pockets for High-Order Guest Binding Beyond Biomimicry.

Molecular recognition lies at the heart of biological functions, which inspires lasting research in artificial host syntheses to mimic biomolecules that can recognize, process, and transport molecules with the highest level of complexity; nonetheless, the design principle and quantifying methodology of artificial hosts for multiple guests (≥4) remain a formidable task. Herein, we report two rhombic dodecahedral cages [(Zn/Fe)Pd-MOC-16], which embrace 12 adaptive pockets for multiguest binding with distinct conformational dynamics inherent in metal-center lability and are able to capture 4-24 guests to manifest a surprising complexity of binding scenarios. The exceptional high-order and hierarchical encapsulation phenomena suggest a wide host-guest dynamic-fit, enabling conformational adjustment and adaptation beyond the duality of induced-fit and conformational selection in protein interactions.

Double-modified oncolytic adenovirus armed with a recombinant interferon-like gene enhanced abscopal effects against malignant glioma.

Background: The development of new therapies for malignant gliomas has been stagnant for decades. Through the promising outcomes in clinical trials of oncolytic virotherapy, there is now a glimmer of hope in addressing this situation. To further enhance the antitumor immune response of oncolytic viruses, we have equipped a modified oncolytic adenovirus (oAds) with a recombinant interferon-like gene (YSCH-01) and conducted a comprehensive evaluation of the safety and efficacy of this modification compared to existing treatments.

[Effects of Reservoir Water Depth on Different Plankton Communities and Keystone Species of Network Interaction].

In order to understand the impacts of the reservoir construction on the diversity and ecological network of different microbial communities, seven sampling sites were set up in the Hengshan Reservoir in 2021. Water samples were collected from the surface and bottom of the reservoir. After filtering and extracting total DNA samples, high-throughput sequencing was carried out based on 16S and 18S rDNA to investigate the response of community structure, molecular ecological network, and keystone species of different microbial groups to water environment changes.

[Efficacy and outcomes of shunt surgery for secondary hydrocephalus].

Records of secondary hydrocephalus patients undergoing shunt surgery in the Department of Neurosurgery of Peking Union Medical College Hospital from September 2012 to April 2022 and their clinical characteristics and outcomes were retrospectively reviewed and analyzed. Among 121 patients who received first time shunt placement, the most common causes of secondary hydrocephalus were brain hemorrhage (55, 45.5%) and trauma (35, 28.

SIRT6 is an epigenetic repressor of thoracic aortic aneurysms via inhibiting inflammation and senescence.

Thoracic aortic aneurysms (TAAs) develop asymptomatically and are characterized by dilatation of the aorta. This is considered a life-threating vascular disease due to the risk of aortic rupture and without effective treatments. The current understanding of the pathogenesis of TAA is still limited, especially for sporadic TAAs without known genetic mutation.

Mass Measurement of Upper fp-Shell N=Z-2 and N=Z-1 Nuclei and the Importance of Three-Nucleon Force along the N=Z Line.

Using a novel method of isochronous mass spectrometry, the masses of ^{62}Ge, ^{64}As, ^{66}Se, and ^{70}Kr are measured for the first time, and the masses of ^{58}Zn, ^{61}Ga, ^{63}Ge, ^{65}As, ^{67}Se, ^{71}Kr, and ^{75}Sr are redetermined with improved accuracy. The new masses allow us to derive residual proton-neutron interactions (δV_{pn}) in the N=Z nuclei, which are found to decrease (increase) with increasing mass A for even-even (odd-odd) nuclei beyond Z=28. This bifurcation of δV_{pn} cannot be reproduced by the available mass models, nor is it consistent with expectations of a pseudo-SU(4) symmetry restoration in the fp shell.

Diagnostic performance of artificial intelligence-based computer-aided diagnosis system in longitudinal and transverse ultrasonic views for differentiating thyroid nodules.

Objective: To evaluate the diagnostic performance of different ultrasound sections of thyroid nodule (TN) using computer-aided diagnosis system based on artificial intelligence (AI-CADS) in predicting thyroid malignancy.

Materials And Methods: This is a retrospective study. From January 2019 to July 2019, patients with preoperative thyroid ultrasound data and postoperative pathological results were enrolled, which were divided into two groups: lower risk group (ACR TI-RADS 1, 2 and 3) and higher risk group (ACR TI-RADS 4 and 5).

Rodlike FeS/SnS@N-C Core-Shell Microparticles for Lithium-Ion Batteries.

FeS/SnS@N-C composites were successfully synthesized through the combination of nucleation self-assembly, N-doped carbon coating, and in situ vulcanization. The experimental results show that the discharge capacitance of FeS/SnS@N-C in the lithium storage process is 796.90 mAh g at 0.

Preoperative Value of Contrast-Enhanced Ultrasound in Totally Laparoscopic Associating Liver Partition and Portal Vein Ligation for Staged Hepatectomy for Liver Tumors: A Preliminary Study.

The clinical data of 15 cases that planned to receive totally laparoscopic associating liver partition and portal vein ligation for staged hepatectomy were retrospectively collected. Before the stage 1 operation, the size and number of the tumors in future liver remnant (FLR) and the presence of cancer embolus in the portal vein were assessed using contrast-enhanced ultrasound (CEUS) and contrast-enhanced computed tomography (CECT). Before the stage 2 operation, CEUS was performed to assess the presence of traffic blood flow between the diseased liver and FLR after round-the-liver ligation.

Observation of a Strongly Isospin-Mixed Doublet in ^{26}Si via β-Delayed Two-Proton Decay of ^{26}P.

β decay of proton-rich nuclei plays an important role in exploring isospin mixing. The β decay of ^{26}P at the proton drip line is studied using double-sided silicon strip detectors operating in conjunction with high-purity germanium detectors. The T=2 isobaric analog state (IAS) at 13 055 keV and two new high-lying states at 13 380 and 11 912 keV in ^{26}Si are unambiguously identified through β-delayed two-proton emission (β2p).

Phytochrome B mediates dim-light-reduced insect resistance by promoting the ethylene pathway in rice.

Increasing planting density is one of the most effective ways to improve crop yield. However, one major factor that limits crop planting density is the weakened immunity of plants to pathogens and insects caused by dim light (DL) under shade conditions. The molecular mechanism underlying how DL compromises plant immunity remains unclear.

Associations of executive function and age of first use of methamphetamine with methamphetamine relapse.

Background And Aims: Methamphetamine (MA) is a psychostimulant associated with a high relapse rate among patients with MA use disorder (MUD). Long-term use of MA is associated with mental disorders, executive dysfunction, aggressive behaviors, and impulsivity among patients with MUD. However, identifying which factors may be more closely associated with relapse has not been investigated.