Differential interference contrast microscopy of human atherosclerotic lesions.

Differential interference contrast microscopy was employed to study sections of human cerebral arteries and aorta. When this procedure was used to observe 0.5-mu-thick sections of plastic-embedded arteries, images were obtained with greater definition of detail than corresponding micrographs of the area using conventional bright-field microscopy.

Human intracranial atherosclerosis. A histochemical and ultrastructural study of gross fatty steak lesions.

A descriptive study of atherosclerotic lesions in human intracranial arteries was undertaken using both light and electron microscopic technics. Arterial segments of human middle cerebral, internal carotid and basilar arteries with gross fatty streak lesions were obtained at autopsy within 4 hours after death, fixed and embedded in plastic. A new technic has been developed in which 0.

A histoenzymatic study of human intracranial atherosclerosis.

A light microscopy study on the localization of enzyme activity within atherosclerotic human intracranial arteries was performed on autopsy material obtained within 4 hours of death. The data suggests that the atherosclerotic process first goes through a proliferative phase and then a degenerative phase culminating in the formation of a plaque. In the proliferative phase, smooth muscle cell proliferation has formed a thickened intima.