Role of Immunohistochemical Analysis of p16 and p53 in Vulvar Carcinoma.

Tumor human papillomavirus (HPV) status is an important prognostic factor in vulvar cancer as indicated in the latest WHO classification of female genital tract tumors. Immunohistochemical detection of p16 is well established as a surrogate biomarker for tumor HPV association, including squamous cell carcinomas of the vulva. HPV-independent vulvar carcinomas are heterogeneous with 2 subcategories according to the TP53 mutation status.

DIALYSIS OF SLEEP AND WAKING FACTORS IN BLOOD OF THE RABBIT.

Dialysis of cerebral venous blood was performed on rabbits during sleep induced by electrical stimulation of the hypnogenic thalamic system or during sustained wakefulness elicited by stimulation of the activating reticular system. The injection of dialysate from a sleeping donor elicited in a normal recipient a moderate sleep which did not differ from normal sleep according to the behavior of the animal and the pattern of the electroencephalogram. The action of the dialysate obtained from sleeping donors was significantly different from that obtained from control donors after sham-stimulation of the thalamus.