Dynamic Contrast-enhanced MRI Processing Comparison for Distinguishing True Progression From Pseudoprogression in High-grade Glioma.

Background: Treatment-related changes may occur due to radiation and temozolomide in glioblastoma and can mimic tumor progression on conventional MRI. DCE-MRI enables quantification of the extent of blood-brain barrier (BBB) disruption, providing information about areas of suspicious postcontrast T1 enhancement. We compared DCE-MRI processing methods for distinguishing true disease progression from pseudoprogression in high-grade gliomas (HGGs).

Metabolomic profiles in allergic rhinitis: a systematic review and meta-analysis.

Background: Allergic rhinitis (AR) is a prevalent chronic inflammatory condition that significantly impacts patient quality of life and poses a substantial public health burden. Recent advancements in metabolomics have facilitated a deeper understanding of the metabolic pathways involved in AR, offering potential for new biomarkers and therapeutic targets.

Objective: This article aims to conduct a systematic review and meta-analysis of clinical studies summarizing the metabolomic profiles of allergic rhinitis (AR) to gain deeper insights into the metabolic changes and pathological processes underlying AR.

Tunable Memory Performances of Hyperbranched Polyimides Functionalized with Metal-Porphyrins.

With the rapid advancement of information technology, the need to achieve ultra-high-density data storage has become a pressing necessity. This study synthesized three hyperbranched polyimides (HBPI-TAPP, HBPI-(Zn)TAPP, and HBPI-(Cu)TAPP) by polymerizing 5,10,15,20-tetrakis(4-aminophenyl)porphyrin (TAPP), which features a cavity for metal ion coordination, with 4,4'-(hexafluoroisopropylidene)diphthalic anhydride (6FDA), to systematically investigate the effect of metal ion species on storage performance. According to the results, memory devices based on HBPI-(Zn)TAPP exhibit volatile SRAM (static random-access memory) characteristics, whereas devices employing HBPI-TAPP and HBPI-(Cu)TAPP demonstrate non-volatile WORM (write-once, read-many) characteristics.

The role and research progress of tumor-associated macrophages in cervical cancer.

Tumor-associated macrophages (TAMs) are important immune cells in the tumor micro-environment (TME) and play a key role in the occurrence and development of cervical cancer. Besides, targeting TAMs can significantly inhibit cervical cancer tumor growth, invasion, metastasis, and angiogenesis as well as affect immune regulation. This review summarizes the correlation between TAM and tumors, the mechanism of action of TAM in cervical cancer, and the potential application of TAM in the treatment of cervical cancer.

-Butyl Hypochlorite: A Reagent for the Synthesis of Chlorinated Oxindole and Indole Derivatives.

-Butyl hypochlorite was employed as a versatile reagent for chlorooxidation of indoles, chlorination of 2-oxindoles, and decarboxylative chlorination of the indole-2-carboxylic acids. Four types of products including 2-chloro-3-oxindoles, 2,2-dichloro-3-oxindoles, 3,3-dichloro-2-oxindoles, and 2,3-dichloroindoles could be selectively obtained in moderate to excellent yields by switching the substrates. Various synthetically useful functional groups, such as halogen atoms, cyano, nitro, and methoxycarbonyl groups, remain intact during the reactions.

[Efficacy and learning curve of 69 cases of robot-assisted resection of retroperitoneal benign tumors].

To explore the efficacy of robotic-assisted retroperitoneal benign tumor resection and to analyze its learning curve. This is a retrospective case series study. The data of patients who underwent robotic-assisted retroperitoneal benign tumor resection from August 2015 to February 2023 at the Department of Retroperitoneal Tumor Surgery was analyzed retrospectively.

Evaluating choroidal vascular changes in young adults with high myopia utilizing swept source optical coherence tomography angiography.

Purpose: Utilizing Swept source optical coherence tomography angiography (SS-OCTA) investigates the changes in the vascular characteristics of the choriocapillaris and larger vascular layers, including Sattler's and Haller's layers, in the macular region of young myopia patients, in order to Enhance our comprehension of the underlying mechanisms of the pathogenesis of myopia.

Methods: A retrospective analysis was performed on 103 young adults (154 eyes) that underwent SS-OCTA. Axial lengths (AL) were measured, 64 eyes with AL < 26.

A comparative analysis of Marburg virus-infected bat and human models from public high-throughput sequencing data.

Marburg virus (MARV) disease (MVD) is an uncommon yet serious viral hemorrhagic fever that impacts humans and non-human primates. In humans, infection by the MARV is marked by rapid onset, high transmissibility, and elevated mortality rates, presenting considerable obstacles to the development of vaccines and treatments. Bats, particularly , are suspected to be natural hosts of MARV.

Stimulation of dorsal root ganglion with low-intensity focused ultrasound ameliorates pain responses through the GABA inhibitory pathway.

Aims: Chronic pain is a critical public health issue that severely impacts quality of life and poses significant treatment challenges, particularly due to the risk of adverse effects associated with pharmacological therapies. The search for effective non-invasive treatment alternatives has become increasingly relevant. Low-intensity focused ultrasound (LIFU) has been identified as an effective non-invasive strategy for pain management, although the underlying mechanism remains unclear.

[Investigation on tastes, properties, and traditional efficacy of Mongolian medicines of genus Artemisia based on pharmacophylogeny].

The genus Artemisia is one of the most abundant groups of medicinal plants in the Asteraceae family. Based on the theoretical basis of the pharmacophylogeny, the phylogenetic analysis, association analysis and other methods were used to systematically sort out the genetic relationships, properties, tastes, chemical constituents, and traditional efficacy of Mongolian medicines of genus Artemisia(MMA). The correlation and regularity were discussed.

Two new sesquiterpene eudesmanolides from the Raeusch.

Two new sesquiterpene eudesmanolides, 5-hydroxy-eudesman-7(11)-en-8(12)-olide (), and 5-hydroxy-7(11)-en-8-oxo-eudesmane (), along with six known sesquiterpene eudesmanolides, were isolated from the leaves and twigs of Raeusch. The structures of these compounds were established basis on NMR and MS spectroscopic analyses. The cytotoxic activities of the isolated compounds were evaluated.

Improving the geographical traceability of tea in China based on stable isotope ratios.

Unlabelled: The potential of improving the classification of tea samples from different regions was studied by using stable isotope ratios analysis. The stable isotope ratios of 44 elements in tea samples were determined ( < 0.05).

Combining ultrasound technology with targeted fucoidan/arginine-gelatin nanoparticles loaded with doxorubicin to enhance therapeutic efficacy and modulate bioeffects in drug-resistant triple-negative breast cancer.

Triple-negative breast cancer (TNBC) presents formidable challenges due to its aggressive nature and high recurrence rates, compounded by the involvement of epithelial-mesenchymal transition (EMT) in its progression and metastasis. Standard chemotherapy, which typically employs doxorubicin (DOX), remains a primary treatment approach. However, multidrug resistance (MDR) mechanisms, which include ATP-binding cassette transporters and EMT, contribute to treatment failures.

Modulation of GABAergic neurons in acute epilepsy using sonogenetics.

Epilepsy, a neurological disorder caused by hypersynchronous neural disturbances, has traditionally been treated with surgery, pharmacotherapy, and neuromodulation techniques such as deep brain stimulation and vagus nerve stimulation. However, these methods are often limited by invasiveness, off-target effects, and poor resolution. We present a noninvasive alternative utilizing sonogenetics to selectively stimulate γ-aminobutyric acid (GABA)ergic neurons in the amygdala through engineered auditory-sensing protein, mPrestin (N7T, N308S), in a pentylenetetrazole-induced rat model.

Role of inflammasomes in Toxoplasma and Plasmodium infections.

Background: The detection of pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs) by multimeric protein complexes, known as inflammasomes, triggers an inflammatory response, which is a critical component of the innate immune system. This inflammatory response plays a pivotal role in host resistance against parasitic infections, presenting a significant global health challenge.

Methods: We systematically searched for relevant articles from the Pubmed and the Web of Science database to summarize current insights into how inflammasomes function in preventing infections caused by the apicomplexan parasites Toxoplasma and Plasmodium.

Nontrivial Raman Characteristics in 2D Non-Van der Waals MoN.

Resonant Raman spectra of a two-dimensional (2D) non-van der Waals (vdW) material, molybdenum nitride (MoN), are measured across varying thicknesses, ranging from a few to tens of nanometers. Fifteen distinct Raman peaks are observed experimentally, and their assignments are made using first-principles calculations for the most stable AABB-stacking structure of MoN. The assignments are further supported by angular-dependent Raman measurements for all peaks, except the most intense one at 215 cm.

A Site-Wise Reliability Analysis of the ABCD Diffusion Fractional Anisotropy and Cortical Thickness: Impact of Scanner Platforms.

The Adolescent Brain and Cognitive Development (ABCD) project is the largest study of adolescent brain development. ABCD longitudinally tracks 11,868 participants aged 9-10 years from 21 sites using standardized protocols for multi-site MRI data collection and analysis. While the multi-site and multi-scanner study design enhances the robustness and generalizability of analysis results, it may also introduce nonbiological variances including scanner-related variations, subject motion, and deviations from protocols.

Feasibility and Psychometric Properties of Integrated Care for Older People Screening Tool for Taiwanese (ICOPES-TW) Cognitive Screening Test.

Background: Intrinsic capacity, a concept proposed by the World Health Organization, includes multidimensions to better understand older adults' health conditions for successful healthy aging. One of the key dimensions of intrinsic capacity is cognition. The present study aimed to examine if the cognitive test in Integrated Care for Older People Screening Tool for Taiwanese (ICOPES-TW) is a suitable instrument for screening cognition impairment.