Maize2035: A decadal vision for intelligent maize breeding.

Maize, a cornerstone of global food security, has undergone remarkable transformations through breeding, yet it faces mounting challenges in a changing world. In this review, we trace the historical successes of maize breeding which laid the foundation for present opportunities. We examine both the specific and shared breeding goals related to diverse geographies and end-use demands.

Protection of glutamine: The NF-κB/MLCK/MLC2 signaling pathway mediated by tight junction affects oxidative stress, inflammation and apoptosis in snakehead (Channa argus).

Lipopolysaccharide (LPS) destroys intestinal mechanical barrier and causes apoptosis by triggering oxidative stress and inflammatory responses. Glutamine (Gln) can maintain normal intestinal function under various stressed or pathological conditions. Thereby, this study aims to evaluate the protection of glutamine on intestinal health of snakehead (Channa argus), specifically regarding the NF-κB/MLCK/MLC2 signaling pathway mediated by tight junction affecting oxidative stress, inflammation and apoptosis.

Clinical practice of one-lung ventilation in mainland China: a nationwide questionnaire survey.

Background: Limited information is available regarding the application of lung-protective ventilation strategies during one-lung ventilation (OLV) across mainland China. A nationwide questionnaire survey was conducted to investigate this issue in current clinical practice.

Methods: The survey covered various aspects, including respondent demographics, the establishment and maintenance of OLV, intraoperative monitoring standards, and complications associated with OLV.

Constructing Lewis Acid-Base Pairs to Boost Electrocatalytic Hydrogenation of p-Nitrobenzoic Acid to Valuable p-Aminobenzoic Acid Using Water as the Hydrogen Source.

Electrocatalytic hydrogenation of toxic nitrobenzene to value-added aniline is of great significance in addressing the issues of energy crisis and environmental pollution. However, it is a considerable challenging and crucial to develop highly efficient and earth-abundant transition metal-based electrocatalysts with superior durability for the electro-hydrogenation of nitrobenzene due to the competitive hydrogen evolution reaction (HER). In this work, a facile approach is designed and introduced to constructing an integrated self-supported heterostructured Co Ni(OH)(CO)/Al(OH) nanoarrays (CoNiCH/Al(OH)) for the electrocatalytic reduction of nitrobenzoic acid (PNBA) to p-aminobenzoic acid (PABA) and its electrocatalytic mechanism for PNBA reduction is investigated.

Fluorescence enhancement of cyanine/hemicyanine dyes with adamantane as an auxochrome through host-guest inclusion with methylated cyclodextrin in water.

Fluorescence of cyanine dyes is often quenched in aqueous solution, limiting their application in water or biological system. In this work, a novel strategy of host-guest interaction based on cyanine derivatives containing auxochromes was proposed to enhance fluorescence in aqueous solution and cell imaging. By using the host (methylated β-cyclodextrin, M-β-CD) to inclusion and suppress the TICT effect of the dye, the fluorescence was significantly enhanced at lower host concentration.

[Effect of WW-domain transcription regulator 1 on aging regulation of human dental pulp stem cells].

Investigating the changes of phenotype and moleculars associated with aging with the increase of passage times of human dental pulp stem cells (hDPSC), to explore the role of WW-containing transcriptional regulator 1 (WWTR1) in the aging mechanism. hDPSCs were cultured by tissue block method, and were divided into 4 groups according to the age, algebra, cell knockdown and overexpression of WWTR1 in hDPSCs. Group Ⅰ: hDPSCs from human teeth were further divided into youth group (15-25 years old) and group middle-aged group (40-50 years old) according to different ages.

Enzymatic modification of wheat starch by a novel maltotetraose-forming amylase from Atopomonas hussainii to retard retrogradation and improve bread quality.

To retard starch retrogradation and improve bread quality, a novel maltotetraose-forming amylase (AhMFA) from Atopomonas hussainii was expressed in Komagataella phaffii. After high cell density fermentation, the enzyme activity reached a maximum level of 3032 U mL. AhMFA showed optimal activity at pH 6.

Exploring structure-directed immunogenic cytotoxicity of arginine-rich peptides for cytolysis-induced immunotherapy of cancer.

The same cells can die with varied immunological consequences. For the purpose of cancer therapy, stronger immunogenic death of cancer cells is considered favorable. Membrane disruptive peptides are cytotoxic agents with tunable structures capable of not just killing heterogeneous cancer cells, but also inducing immunogenic death.

The Roles of Molecular Concavities in the Hierarchical Self-Assembly of Giant Tetrahedra for CO Uptake.

Giant tetrahedral molecules have sparked significant interest in the past decade due to their unique and diverse supramolecular nanostructures. The longer and bulkier peripheral substituents create deep molecular concavities and thus contribute to the different self-assembly behaviors compared to the conventional small tetrahedral molecules. In this study, a molecular giant tetrahedra, TetraNDI, was synthesized to investigate the important roles of the molecular concavities in the self-assembly mechanism.

[A case-control study on the associations of parental smoking and alcohol consumption during the periconceptional period and their interactions with risk of congenital heart disease in offspring].

Objectives: To explore the associations of parental smoking and alcohol consumption during the periconceptional period and their interactions with risk of congenital heart disease (CHD) in offspring.

Methods: The parents of children with simple CHD aged 0 to 1 year (=683) were recruited as the case group, while the parents of healthy children aged 0 to 1 year (=740) served as the control group. A case-control study was conducted, and a questionnaire was used to collect information on perinatal exposures.

Prognostic Factors for Anterior Cerebral Artery Aneurysms: A Single-Center Series.

Objective: The aim of the present study is to summarize the characteristics of anterior cerebral artery aneurysms and to explore the prognostic factors of microsurgical clipping treatment for anterior cerebral artery aneurysms.

Materials And Methods: A total of 90 anterior cerebral artery aneurysms (ACAAs) are reviewed from January 2000 to July 2019. Patients are categorized into good outcome group and poor outcome group according to Glasgow outcome scale scores.

Oncolytic avian reovirus-sensitized tumor infiltrating CD8 T cells triggering immunogenic apoptosis in gastric cancer.

Background: Gastric cancer (GC) is a leading malignant disease in numerous countries, including Taiwan with limited therapeutic options. Animal viruses including oncolytic avian reovirus (ARV) have the possibility to avoid pre-existing immunity in humans, while being safe and immunostimulatory. Here, we provide a novel insight into oncolytic ARV and UV-ARV-sensitized patient's peripheral blood mononuclear cells (P-PBMCs) and tumor infiltrating lymphocytes (TILs) killing primary GC (PGC) cells through the surface TLR3 and TRAIL/DR4/DR5 immunogenic apoptosis pathway.

Rational Design and Fine Fabrication of Passive Daytime Radiative Cooling Textiles Integrate Antibacterial, UV-Shielding, and Self-Cleaning Characteristics.

Passive daytime radiative cooling (PDRC) textiles hold substantial potential for localized outdoor cooling of the human body without additional energy consumption, but their limited multifunctional integration severely hinders their practical application. Herein, aluminum-doped zinc oxide (AZO) nanoparticles were purposefully introduced into poly(vinylidene fluoride) (PVDF) nanofibers via a facile electrospinning process, forming a large-scale and flexible PDRC textile with the desired antibacterial, UV-shielding, and self-cleaning capabilities. These prepared PDRC textiles present a weighted sunlight reflection rate of 92.

The effect of comprehensive psychological interventions on the mental health of the community elderly.

Objective: To observe the intervention effect of comprehensive psychological interventions on the mental health of the elderly population.

Methods: 133 elderly aged 60 and above in two urban districts of Tianshui City from January 2020 to December 2020 were selected and divided into the intervention group (n=67) and the control group (n=66). The intervention group received comprehensive psychological interventions, with no intervention given to the control group.

[Maternal gene polymorphisms and their interactions with periconceptional folic acid supplementation in relation to offspring ventricular septal defects].

Objectives: To investigate how maternal gene polymorphisms and their interactions with periconceptional folic acid supplementation are associated with the incidence of ventricular septal defects (VSD) in offspring.

Methods: A case-control study was conducted, recruiting 426 mothers of infants with VSD under one year old and 740 mothers of age-matched healthy infants. A questionnaire survey collected data on maternal exposures, and blood samples were analyzed for genetic polymorphisms.

Systemic immunoinflammatory index and prognostic nutrition index for predicting pathologic responses of patients with advanced gastric cancer after neoadjuvant therapy for advanced gastric cancer.

To investigate the value of prognostic nutrition index (PNI) and systemic immunoinflammatory index (SII) for predicting pathological responses of patients with advanced gastric cancer (GC) after neo-adjuvant chemotherapy (NACT). The clinicopathological data of 326 patients with advanced GC who received NACT in Xiangya School of Medicine, Central South University (The First People's Hospital of Changde City) from January 2017 to December 2021 were retrospectively collected. The SII and PNI of patients were calculated.

Coordination Chemistry and Reactivity of a Lewis Acidic Di-Zinc Framework Supported by Bisphenoxymethanone Ligands.

We present the synthesis, structural characterization, and reactivity studies of a tetra-zinc complex supported by the bisphenoxymethanone ligands and its transformation into various di-zinc architectures. Our findings highlight the potential of these complexes in molecular recognition, supramolecular chemistry, and catalysis.