[Radionuclide ventriculographic assessment of cardiac function based on the analysis of cardiac reserve during dynamic exercise].

To evaluate the contribution of myocardial contractility and preload to increase cardiac output during supine bicycle exercise, quantitative radionuclide ventriculography was performed at rest (R) and during peak exercise (Ex) in 43 patients with coronary artery disease (CAD) and 13 normal subjects. Myocardial contractility was estimated from the ratio of peak systolic pressure to end-systolic volume index (P/V index). During Ex in normal subjects, P/V index invariably increased and its percent change from R to Ex averaged 98 +/- 46 percent.

[Clinical studies of SM-4300 in combination with antibiotics against severe bacterial infections].

SM-4300, a newly developed human immunoglobulin preparation was evaluated in 24 patients with severe bacterial infections and the following results were obtained. The clinical efficacy was excellent in 4 cases, good in 7, fair in 5, poor in 3 and unknown in 5 with the effective rate of 57.9%.

Involvement of autolysin in cellular lysis of Bacillus subtilis induced by short- and medium-chain fatty acids.

The addition of saturated C6, C8, C10, and C12 fatty acids appeared to lyse actively growing cells of Bacillus subtilis 168, as judged by a decrease in the optical density of the culture. Of these fatty acids, dodecanoic acid was the most effective, with 50% lysis occurring in about 30 min at a concentration of 0.5 mM.

Survival of human normal thyroid cells after X-ray irradiation.

Normal thyroid cells from 25 individuals treated surgically for malignant or benign thyroid tumour were cultured in vitro and radiation induced cytotoxicity was studied. The mean lethal dose (Do), quasi-threshold (Dq), and extrapolation number (n) of survival curves of actively dividing thyroid cells assayed by colony formation were estimated to be 92.9 +/- 2.

[Experimental and clinical studies on cefmetazole in the field of internal medicine].

Susceptibilities in various types of clinical isolates to cefmetazole (CMZ) were determined by the disk method and the serial agar dilution method for MIC measurement. CMZ showed high antibacterial activity for all Gram-positive cocci except E. faecalis, and for H.

Streptozotocin effective for treating multiple-hormone-producing malignant islet cell tumor.

A woman with a multiple-hormone-producing pancreatic islet cell tumor with hepatic metastases and with recurrent hypoglycemic attacks, was treated with streptozotocin. After this treatment, the elevated serum levels of insulin, C-peptide, glucagon and serotonin fell markedly and the low level of fasting blood glucose returned to normal. In accordance with these hormonal changes, scintiscan and CT scan revealed marked regression of the metastatic tumors in the liver.

Hepatocellular carcinoma and metastatic cancer detected by iodized oil.

An oily contrast medium was injected into the hepatic artery in rabbits with implanted VX2 carcinoma in the liver. The contrast medium was initially detected in all of the branches of the injected artery, but 3 and 7 days after injection it was found only in the tumor tissue on plain radiographs. Taking advantage of this phenomenon, an oily contrast medium was injected into the hepatic artery in 5 patients with liver tumors.

Hepatic hematoma after blunt trauma--a case of nonoperative management to prevent liver abscess formation.

In an eighteen-year-old boy with a high fever, an intra-hepatic infectious hematoma following blunt hepatic trauma was treated twice with intrahepatic arterial injection chemotherapy in an attempt to prevent conversion of the hematoma to an abscess. A decrease in body temperature occurred after the arterial injections, and the hematoma was gradually diminished in size. In selected patients with blunt hepatic trauma, intrahepatic arterial injection chemotherapy seems to be an effective treatment for prevention of liver abscess formation.

[The analysis of left ventricular filling dynamics by radionuclide ventriculography using ECG's R wave and the second heart sound gating techniques].

To assess the impairment of early diastolic left ventricular (LV) filling and the effect of atrial contraction on total LV filling in patients (pts) with coronary artery disease (CAD), LV volume (LVV) changes during rapid filling (RF) and atrial contraction (AC) phases were studied by equilibrium radionuclide ventriculography in 10 normals (N) and 17 pts with CAD including eight without (CAD-1) and nine with (CAD-2) previous myocardial infarction (MI). The data were acquired in a list-mode fashion as a series of X, Y coordinates, time markers and an ECG's R wave (R) plus the second heart sound (S2) markers. LVV curves were obtained from three types of multi-gated images by (1) R-synchronized forward reformatting for the analysis of systolic phase (ejection fraction; EF and peak ejection rate; PER), (2) S2-synchronized forward reformatting for the analysis of RF phase (peak filling rate; PFR-RF and filling fraction; FF) and (3) R-synchronized backward reformatting for the analysis of AC phase (peak filling rate; PFR-AC and LVV increment with atrial contraction/stroke volume; AC/SV).

[Concentrations of cefotiam and cefmenoxime in the human bone marrow blood and osseous tissue].

Prophylactic antimicrobial therapy for the prevention of infection during total joint arthroplasty or spinal surgery was investigated using cefotiam (CTM) and cefmenoxime (CMX), which are cephems having broad antimicrobial spectrum. Seven patients received 2 g of CTM, and 12 patients 2 g of CMX, by intravenous drip infusion over 15 minutes. Blood, bone marrow and osseous tissue samples were obtained at the end of the infusion, and 30, 60, 90 and 120 minutes after the beginning of the infusion.

Syntheses and biological activities of new carbapenem derivatives.

3-beta-Alanyloxymethyl, 3-glycyloxymethyl and 3-methyl derivatives of 6-(1-hydroxyethyl)-carbapenems, (VIIa, VIIb and VIII), and 3-methyl-6-(1-hydroxyethyl)carbapenam (IX) were synthesized from 3-(1-tert-butyldimethylsilyloxyethyl)-4-(3-chloro-2-oxopropyl) -2-azetidinone (I). The antibacterial activities of these compounds proved that the delta 2 double bond was essential for the appearance of bioactivity, whereas the amino group on the C-3 side chain was not necessary.

Studies on anticancer treatment with an oily anticancer drug injected into the ligated feeding hepatic artery for liver cancer.

In six adult patients with nonresectable liver cancer, as well as in mature New Zealand white rabbits with implanted VX2 carcinoma in the liver, the artery feeding the hepatic lobe with the malignant lesion was ligated, and an oily contrast medium (Lipiodol Ultra-Fluid) was injected into the hepatoproximal lumen of the ligated artery of the liver with carcinoma. The oily contrast medium was detected in all the branches of the artery injected, and thereafter was found only in tumor tissue for 7 days experimentally and for 16 months clinically. Taking advantage of this phenomenon, the therapeutic effect of the injection of an oily anticancer drug (bleomycin oil suspension) into the hepatoproximal lumen of the ligated hepatic artery was investigated in rabbits with VX2 carcinoma of the liver.

Effect of arterial administration of high-molecular-weight anticancer agent SMANCS with lipid lymphographic agent on hepatoma: a preliminary report.

A clinical evaluation of arterial infusion of high-molecular-weight antitumor agent SMANCS dissolved in lipid lymphographic agent (thiodol) in 44 patients with mostly unresectable hepatoma is described. The treatment regimen demonstrated significant merits both therapeutically and diagnostically. Marked antitumor effects were shown in the decreased serum alpha-fetoprotein levels (86% of cases) and tumor size (95% of cases), and in survival period and histological findings.