Selective photothermolysis to target sebaceous glands: theoretical estimation of parameters and preliminary results using a free electron laser.

Background And Objectives: The success of permanent laser hair removal suggests that selective photothermolysis (SP) of sebaceous glands, another part of hair follicles, may also have merit. About 30% of sebum consists of fats with copious CH(2) bond content. SP was studied in vitro, using free electron laser (FEL) pulses at an infrared CH(2) vibrational absorption wavelength band.

Selective photothermolysis of lipid-rich tissues: a free electron laser study.

Background And Objectives: In theory, infrared vibrational bands could be used for selective photothermolysis of lipid-rich tissues such as fat, sebaceous glands, or atherosclerotic plaques.

Study Design/materials And Methods: Absorption spectra of human fat were measured, identifying promising bands near 1,210 and 1,720 nm. Photothermal excitation of porcine fat and dermis were measured with a 3.

Sustained kilowatt lasing in a free-electron laser with same-cell energy recovery.

Jefferson Laboratory's kW-level infrared free-electron laser utilizes a superconducting accelerator that recovers about 75% of the electron-beam power. In achieving first lasing, the accelerator operated "straight ahead" to deliver 38-MeV, 1.1-mA cw current for lasing near 5 &mgr;m.

Scanning electron-stimulated desorption microscopy of red blood cells.

Scanning electron-stimulated desorption (SESD) has been used to image the surface of unfixed red blood cells with high surface specificity and with a lateral spatial resolution of less than or equal to 1 micron. The micrographs were obtained using a scanning Auger microprobe with an appended secondary ion mass spectrometer (SIMS). The instrument was operated at low electron beam energies (2 kV) to maximize electron-stimulated desorption probabilities and minimize the interaction of the electrons with the biological substrate.