Embryoscopy and targeted embryo biopsy for the management of early abortion.

Purpose: To evaluate the safety, accuracy, and effectiveness of embryoscopy for the management of early abortion and to test the hypothesis that targeted embryo and chorionic villi sampling avoids maternal cell contamination (MCC) for genetic testing of products of conception (POC).

Methods: This ambispective study included 74 consecutive patients presenting with early abortion. Gestations between 5 and 9 weeks, obtained either spontaneously or through assisted reproductive technologies were included.

Dynamics of PCV2 and PCV3 in the Serum and Oral Fluids of Pigs After PCV2 Vaccination in a Commercial Farm.

Objectives: This study investigated the dynamics of porcine circovirus type 2 (PCV2) and PCV3 on a commercial farm following PCV2 vaccination.

Methods: Serum samples from 35 pigs, starting at 3 weeks of age, were collected weekly until 21 weeks of age. Oral fluids from six pens of pigs of the same age were also analyzed.

Release of Biopolymers from Biomass Through Thermal and Non-Thermal Technologies.

Components of yeast cell walls, such as β-glucans and mannoproteins, show promise for developing sustainable biopolymers for food packaging. Efficient extraction, however, is challenging due to the complexity of the yeast cell wall. This study explored high-pressure homogenisation (HPH) and pulsed electric fields (PEFs), alone and with heat treatment (TT), on bakery yeast (BY) and brewery spent yeast (BSY) biomasses.

An Evaluation of the Cellular and Humoral Response of a Multi-Epitope Vaccine Candidate Against COVID-19 with Different Alum Adjuvants.

SARS-CoV-2 () is responsible for the disease identified by the World Health Organization (WHO) as COVID-19. We designed "CHIVAX 2.1", a multi-epitope vaccine, containing ten immunogenic peptides with conserved B-cell and T-cell epitopes in the receceptor binding domain (RBD) sequences of different SARS-CoV-2 variants of concern (VoCs).

The IBEX Imaging Knowledge-Base: A Community Resource Enabling Adoption and Development of Immunofluoresence Imaging Methods.

The iterative bleaching extends multiplexity (IBEX) Knowledge-Base is a central portal for researchers adopting IBEX and related 2D and 3D immunofluorescence imaging methods. The design of the Knowledge-Base is modeled after efforts in the open-source software community and includes three facets: a development platform (GitHub), static website, and service for data archiving. The Knowledge-Base facilitates the practice of open science throughout the research life cycle by providing validation data for recommended and non-recommended reagents, e.

Immunogenicity of the CoronaVac vaccine in children: a real-world study.

Background: Despite its proven effectiveness and safety, there are limited real-world data on CoronaVac's immunogenicity in children, especially in lower-income countries, particularly for SARS-CoV-2 variants. We present a real-world study evaluating CoronaVac's immunogenicity in Colombian children stratified by previous exposure to this virus.

Methods: 89 children aged 3-11 years were enrolled (50 Non-Exposed and 39 Exposed).

Longitudinal performance trajectories of young female sprint runners: a new tool to predict performance progression.

Background: Longitudinal performance tracking in sports science is crucial for accurate talent identification and prognostic prediction of future performance. However, traditional methods often struggle with the complexities of unbalanced datasets and inconsistent repeated measures.

Purpose: This study aimed to analyze the longitudinal performance development of female 60 m sprint runners using linear mixed effects models (LMM).

Adolescents and Young Adults with Germline CDH1 Variants and the Risk of Overtreatment.

Background: Adolescents and young adults (AYA) with germline CDH1 variants are at risk of overtreatment when precancer lesions are detected with endoscopic screening. We characterize diffuse-type gastric cancer prevalence and survival in AYA managed with prophylactic total gastrectomy (PTG) or endoscopic surveillance.

Methods: Prospective cohort study of 188 individuals aged 39 and younger enrolled from January 27, 2017, to May 1, 2023.

New Constraints on the Melting Temperature and Phase Stability of Shocked Iron up to 270 GPa Probed by Ultrafast X-Ray Absorption Spectroscopy.

Studying the properties and phase diagram of iron at high-pressure and high-temperature conditions has relevant implications for Earth's inner structure and dynamics and the temperature of the inner core boundary (ICB) at 330 GPa. Also, a hexagonal-closed packed to body-centered cubic (bcc) phase transition has been predicted by many theoretical works but observed only in a few experiments. The recent coupling of high-power laser with advanced x-ray sources from synchrotrons allows for novel approaches to address these issues.

Seroprevalence of Brucellosis in Livestock and Farmers' Choice of Milk Marketing Channels in Rwamagana District, Rwanda.

Brucellosis remains an endemic disease in livestock populations in Rwanda, but the prevalence of the disease varies by geographic region. The common use of informal milk marketing channels represents a health hazard to humans when milk from Brucella-infected cows from one or more households is mixed with milk from other households for human consumption. In Rwanda, knowledge about the burden of brucellosis in livestock and factors associated with farmers' choice of milk marketing channels is very limited.

Retraction Notice to: Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal.

[This retracts the article DOI: 10.1016/j.isci.

Permanent Neonatal Diabetes with High Insulin Requirements Due to a New Variant in the Gene.

Neonatal diabetes is an infrequent disorder that may present as transient, permanent, or syndromic. It is most commonly caused by pathogenic variants involving the ABCC8, KCNJ11, and INS genes. To describe a neonate with permanent diabetes mellitus due to a previously unreported variant in the INS gene, outlining the diagnostic complexities, therapeutic interventions, and related clinical challenges.

Variation in brain aging: A review and perspective on the utility of individualized approaches to the study of functional networks in aging.

Healthy aging is associated with cognitive decline across multiple domains, including executive function, memory, and attention. These cognitive changes can often influence an individual's ability to function and quality of life. However, the degree to which individuals experience cognitive decline, as well as the trajectory of these changes, exhibits wide variability across people.

Comparative Study of Adalimumab, Infliximab and Certolizumab Pegol in the Treatment of Cystoid Macular Edema Due to Behçet's Disease.

The leading cause of blindness due to non-infectious uveitis is cystoid macular edema (CME). Behçet's disease (BD) is one of the most commonly conditions related to CME. To compare the effectiveness and safety of adalimumab (ADA), infliximab (IFX) and certolizumab (CZP) in refractory CME due to BD.

Comprehensive radiographic grading system and clinical outcomes of canine tibial avulsion fractures in dogs.

The tibial apophysis is a separate center of ossification in the proximal tibia of skeletally immature dogs. Because it is made of cartilage during development, it is prone to fractures (avulsions) and other tensile-related injuries. One prior veterinary study proposed a classification system for proximal tibial apophyseal fractures, but this study did not include fractures that involved the proximal tibial physis or metaphysis, which have been described in human classification systems.

Luminescence and Generation of Reactive Oxygen Species in Solution by Ta6Br12 Clusters.

An intrinsic metal cluster NIR-II emission of the {Ta6Br12}2+ aqua/hydroxocomplexes was determined in aqueous solutions under inert atmosphere. The photoluminescence (PL) is enhanced in D2O, and the lifetime scale expands from nanoseconds to microseconds. Possible cluster emission transitions have been assigned and analyzed from a computational perspective.

Behavioral Weight Loss Treatment Promotes Weight Loss by Increasing Eating Disorder Symptoms: A Response to Grilo & Pittman (2024).

We provide commentary on the Grilo and Pittman (2024). Exploring Dietary Restraint as a Mediator of Behavioral and Cognitive-Behavioral Treatments on Outcomes for Patients With Binge-Eating Disorder With Obesity article published in the International Journal of Eating Disorders. Grilo and Pittman show that weight loss in the Behavioral Weight Loss Treatment condition is mediated by an increase in rigid restraint, whereas binge eating is not mediated by rigid restraint.

Exploring Interrupted Nazarov Cyclizations Using Tethered Sulfonamide Nucleophiles: Insights into Capture Pathways.

This manuscript describes a study of diverse reaction outcomes that stem from the ionization of -alkynyl-Prins adducts. Experimental results have demonstrated unexpected behavior in the nitrogen-containing systems compared to the analogous oxygen derivatives derived from -Prins/-Nazarov sequences. In-depth experimental studies and computational analysis revealed an intricate mechanism involving competing -Nazarov and -Nazarov pathways.

Preferences of citizens in Peru for school opening during a public-health crisis: A participatory value evaluation study.

Background: The outbreak of COVID-19 was followed by an unprecedented package of measures to protect public health. Over 150 countries mandated school closures to reduce the risk of transmission. Decisions on whether to close schools involve trade-offs between important effects on public health, learning outcomes, well-being of children, productivity of parents.

Establishing vocabulary tests as a benchmark for evaluating large language models.

Vocabulary tests, once a cornerstone of language modeling evaluation, have been largely overlooked in the current landscape of Large Language Models (LLMs) like Llama 2, Mistral, and GPT. While most LLM evaluation benchmarks focus on specific tasks or domain-specific knowledge, they often neglect the fundamental linguistic aspects of language understanding. In this paper, we advocate for the revival of vocabulary tests as a valuable tool for assessing LLM performance.

Suboptimal vitamin D status and overweight/obesity are associated with gut integrity and inflammation in minority children and adolescents: A cross-sectional analysis from the MetA-bone trial.

Preserving gut integrity is essential to preventing the development of chronic diseases. Several factors are associated with gut integrity and inflammation in adults. However, there is limited evidence in healthy children.

Analysis of COVID-19 patients hospitalized in general wards and intensive care units: Insights from the RIMAC cardiopulmonary imaging registry across Latin American centers.

Objectives: This study aimed to compare various aspects among coronavirus disease 2019 (COVID-19) patients admitted to general wards versus intensive care units (ICUs) in Latin American (LATAM), including demographics, comorbidities, imaging and laboratory findings, complications, treatments, and predictors of mortality.

Materials And Methods: Data from the LATAM cardiopulmonary imaging registry of hospitalized COVID-19 patients (RIMAC) were analyzed. RIMAC is a prospective observational study conducted from March to December 2020 across 12 tertiary centers in nine LATAM countries.