Lack of association of histocompatibility antigens with primary open-angle glaucoma.

Eighty-seven patients (35 with primary open-angle glaucoma, 20 with angle-closure glaucoma, and 32 controls) underwent HLA typing of peripheral lymphocytes. Sixteen specificities were detected at the A locus, 19 at the B locus, and four at the C locus. No significant differences were found between patients with either type of glaucoma and control patients.

Leucocyte-migration inhibition induced by uveoretinal antigen in patients with diabetic retinopathy.

Leucocyte-migration inhibition was to determine the state of hypersensitivity in 65 diabetic patients with different stages of retinopathy and 21 nondiabetic controls. About one third of the patients with simple or proliferative retinopathy exhibited significant leucocyte-migration inhibition of 0.2 mg/ml.

Histocompatibility (HL-A) antigens and primary open-angle glaucoma.

To assess the association between open-angle glaucoma and HL-A antigens, the frequencies of 25 HL-A antigens were determined in 49 patients with OAG, and 22 patients with increased intraocular pressure, due to causes other than OAG, using the microcytotoxicity method. The results were compared to 250 individuals from the general population who were tested in the same laboratory at the same period of time. Using rigid statistical analysis, the incidence of the Bw35 antigen was found to be significantly (less than 0.

Leucocyte migration test in patients after corneal transplantation.

Twenty-four patients with corneal homografts were repeatedly evaluated by the leucocyte migration test using pooled human corneal extract 0.2 mg/ml as antigen. All patients were treated with small doses of local or systemic steroids.

Leukocyte migration inhibition in chorioretinitis.

Leukocyte migration inhibition (LMI) by choroid, retina, and uveal tract antigens was studied in patients with active and quiescent chorioretinal disease. LMI by retina was more frequent in both groups of patients, occurring in 9 of 16 patients with active disease and in 8 to 15 patients with disease in remission. Choroid was tested in 15 patients with active inflammation and led to LMI in 7 of them when they were off steroid therapy; it produced LMI in 3 of 13 patients whose disease appeared healed.