Characteristics of the cytoplasmic and nuclear dihydrotestosterone receptors of human thymic tissue.

Dihydrotestosterone receptor was prepared from both the cytoplasm and nucleus of human thymic tissue. Human cytoplasmic and nuclear dihydrotestosterone receptor possessed a KA greater than 1.0 and by competition assay was highly specific for dihydrotestosterone.

Glucose and insulin changes in infants and children undergoing hypothermic open-heart surgery.

Marked hyperglycemia was observed in patients undergoing hypothermic open-heart surgery. To evaluate potential mechanisms responsible for hyperglycemia, paired samples were evaluated for glucose and insulin levels in 3 groups of patients. Group 1 consisted of 8 patients less than 2 years of age undergoing cardiac surgery requiring total circulatory arrest; Group 2 consisted of 9 patients less than 2 years of age undergoing open-heart procedures but not requiring total circulatory arrest; Group 3 consisted of 10 patients greater than 2 years of age, none of whom required total circulatory arrest.

Early medical and surgical intervention for tetralogy of Fallot with absence of pulmonic valve.

Tetralogy of Fallot with absent pulmonic valve is a rare but life-threatening syndrome. Children with this complex may have aneurysmally dilated pulmonary arteries which compress the tracheobronchial tree and cause airway compromise and death. This paper reviews the course of 10 children with this syndrome who were seen at our institution from 1962 until the present.

Repair of a subvalvular left ventricular aneurysm following mitral valve replacement.

Left ventricular aneurysms are a frequent complication of myocardial infarction. Some aneurysms occur secondary to trauma, previous operation, or infection. This report presents the case of a patient with a posterior submitral left ventricular aneurysm, which occurred following mitral valve replacement.

Late results of reconstruction of the right ventricular outflow tract with porcine xenografts in children.

Thirty-three children, aged 2.5 to 17.5 years (mean, 8.

Measurement of the ohmic electrode-tissue contact resistance and the voltage applied to myocardium.

The electrical impedance of a pulse generator-electrode-heart system is a complex one. By analysis of an equivalent circuit developed for the above, a model was derived to describe the output voltage applied to an implanted electrode. On the basis of the dynamic behavior of the equivalent circuit when a pacing pulse was applied, a method for measuring true ohmic electrode-tissue contact resistance was developed, and a device was constructed to provide an instant digital readout of its value.

Nitroprusside and epinephrine for treatment of low output in children after open-heart surgery.

We evaluated the acute hemodynamic effects of treatment of the low output state with sodium nitroprusside and epinephrine in 13 children after intracardiac operation. The 13 patients were selected from a consecutive series of 106 children undergoing cardiopulmonary bypass. They had a cardiac index less than 2.

Low-cost daily pacemaker monitoring system.

To reduce the cost of pacemaker monitoring, we developed an inexpensive cardiac pacemaker interval monitor that detects electromagnetic radiation of the electrical pulse generated by an implanted pacemaker. The pulse interval is timed by logic systems and a piezoelectric crystal. Pulse interval is computed to the nearest 0.

Nitroprusside after open-heart surgery.

The effects of intravenous infusion of sodium nitroprusside were studied in 11 children immediately after open-heart surgery for congenital heart disease. The patients were selected because, following bypass, their cardiac index was below 2,0 L/min/m2 and their systemic vascular resistance exceeded 30 units. In order to eliminate the effects of preload, mean left atrial pressure was maintained at a constant level by blood transfusion.

Cardiac performance and oxygen consumption during intracardiac operations in children.

Cardiac performance and oxygen consumption in 30 patients undergoing surgical treatment for congenital cardiac disease were determined from intraoperative measurements. Arterial pressure, cardiac index, mean left ventricular hydraulic output power, pulmonary artery oxygen saturation were obtained at average mean left atrial pressures of 8.1 and 15.