Effects of cooperative learning on undergraduate nursing students: a quasi- experimental study.

Aim: This study evaluated the effect of cooperative learning on the attitude, satisfaction, and performance of undergraduate nursing students enrolled in community nursing courses.

Design: A one-group pretest-posttest quasi-experimental design.

Methods: This study was conducted at a university in northern Taiwan.

Impacts of night shift on medical professionals: a pilot study of brain connectivity and gut microbiota.

Night shift is a prevalent workstyle in medical hospitals, demanding continuous health monitoring and rapid decision making of medical professionals. Night shifts may cause serious health problems to medical staff, including cognitive impairments, poor sleep, and inflammatory responses, leading to the altered gut-brain axis. However, how night shifts impact gut-brain axis and how long the impact lasts remain to be studied.

Multicenter validation of a machine learning model to predict intensive care unit readmission within 48 hours after discharge.

Background: Intensive care unit (ICU) readmission is a crucial indicator of patient safety. However, discharge decisions often rely on subjective assessment due to a lack of standardized guidelines. We aimed to develop a machine-learning model to predict ICU readmission within 48 h and compare its performance to traditional scoring systems.

Beyond the bleed: Navigating fetal intraventricular hemorrhage.

Antenatal intraventricular hemorrhage (IVH) is intracranial hemorrhage that occurs in utero at an incidence of 1-5 per 10,000. Though there is very limited data on neurodevelopmental prognosis, antenatally diagnosed fetal intracranial hemorrhages carry a very poor prognosis with an estimated 40% mortality in utero or within the first month after birth. Less than 50% of survivors have normal neurodevelopmental outcomes during their postnatal follow-up.

A model for predicting day-100 stem cell transplant-related mortality in AL amyloidosis.

Autologous stem cell Transplant (ASCT)-related mortality (TRM) in AL amyloidosis remains elevated. AL amyloidosis patients (n = 1718) from 9 centers, transplanted 2003-2020 were included. Pre-ASCT variables of interest were assessed for association with day-100 all-cause mortality.

Neonatal Intensive Care Unit Use for Newborns With Relatively Lower Illness Acuity.

Background And Objectives: Neonatal intensive care unit (NICU) aggregate service and outcome descriptions focus on high-illness-acuity neonates. We sought to describe the high-level landscape of lower-acuity inborn NICU admissions (LAINAs).

Methods: This cross-sectional study of a nearly three-quarters population sample from 2022 describes 120 California hospitals with inborn NICU admissions.

Synergistic Effects of Transarterial Chemoembolization and Lenvatinib on HIF-1α Ubiquitination and Prognosis Improvement in Hepatocellular Carcinoma.

Purpose: A recent trial has shown that adding transarterial chemoembolization (TACE) to lenvatinib therapy results in enhanced therapeutic efficacy in hepatocellular carcinoma (HCC). We aimed to assess the effectiveness of the lenvatinib and TACE combination in a real-world clinical context for managing HCC and to elucidate the molecular pathways involved.

Experimental Design: This retrospective analysis included 199 patients diagnosed with HCC and having intrahepatic lesions between 2018 and 2021.

Fabry Disease Podocytes Reveal Ferroptosis as a Potential Regulator of Cell Pathology.

Introduction: Fabry disease (FD) results from pathogenic variants, leading to a deficiency in lysosomal α-galactosidase A (α-Gal A) and accumulation of the sphingolipid globotriaosylceramide (Gb3). This leads to severe renal and cardiovascular complications, primarily affecting kidney podocytes. As a multisystemic disorder, FD initiates at the cellular level; however, the mechanism(s) underlying Gb3-induced cell dysfunction remain largely unknown.

Analysis of crosslinking sites suggests PIWI Argonaute exhibits flexible conformations for target recognition.

Small RNAs play critical roles in gene regulation in diverse processes across organisms. Crosslinking, ligation, and analyses of sequence hybrid (CLASH) experiments have shown PIWI and Argonaute proteins bind to diverse mRNA targets, raising questions about their functional relevance and the degree of flexibility in target recognition. As crosslinking-induced mutations (CIMs) provides nucleotide-resolution of RNA binding sites, we developed MUTACLASH to systematically analyze CIMs in piRNA and miRNA CLASH data in .

Remote versus in-person pre-service neonatal resuscitation training: A noninferiority randomized controlled trial in Ethiopia.

Background: In-person neonatal resuscitation training in resource-limited settings faces barriers of geographic access, facilitator and participant availability, and high costs. Remote training could overcome these challenges while maintaining effectiveness. We hypothesized that remote neonatal resuscitation training was noninferior to in-person training for acquiring and retaining knowledge and skills for pre-service education in Ethiopia.

Improving commitment to family-centered care in the NICU: a multicenter collaborative quality improvement project.

Objective: Despite evidence demonstrating the positive impact of family-centered care (FCC) in the neonatal intensive care unit (NICU), FCC is not standard of care. This multi-center, quality improvement initiative aimed to increase the percentage of NICUs with FCC committees and Family Partnership Councils (FPCs).

Study Design: Participating NICUs were divided into small groups for collaborative mentoring.

Clinical Efficacy of Sialendoscopy-Assisted Stone Removal for Non-Palpable Hilar and Intraglandular Submandibular Sialoliths.

Objectives: This study aimed to assess the efficacy of sialendoscopy in retrieving non-palpable submandibular stones located in the hilum or deeper parenchyma compared to traditional non-endoscopic transoral stone removal techniques.

Methods: Seventy patients with non-palpable submandibular hilar or intraparenchymal stones underwent sialendoscopy-assisted stone removal (SASR). Seventeen patients with hilar stones treated with non-endoscopic transoral stone removal (TOSR) were the control group.

Infantile myofibromatosis: Small bumps pose big problems.

Background: Infantile myofibromatosis (IM) is a disorder characterized by proliferation of benign myofibroblastic tumors that typically manifest as solitary or multiple nodules in the skin, muscle, bone, subcutaneous tissues, and visceral organs and can pose significant morbidity and mortality risks, particularly in cases involving visceral organs or causing functional impairment. These soft tissue lesions are the most prevalent benign fibrous tumors that present before age two and can undergo spontaneous regression or are amenable to surgical resection.

Case: A preterm, male infant was born via Caesarean section to a mother with a trichorionic, triamniotic pregnancy following preterm labor.

Targeting Caseinolytic Mitochondrial Matrix Peptidase, a Novel Contributor to High-risk Behavior, in Multiple Myeloma.

Plasma cell dyscrasias encompass a spectrum from the precursors monoclonal gammopathy of undetermined significance and smoldering myeloma to symptomatic myeloma, but the genes that enable progression and confer poor prognosis are incompletely understood. Using single cell transcriptomics, we identified the Caseinolytic protease proteolytic subunit (CLPP), a key component of the mitochondrial CLP serine endopeptidase, as being over-expressed in CD138+ neoplastic versus normal, and in symptomatic versus precursor plasma cells. Its high expression was associated with an adverse prognosis across multiple molecularly defined subgroups in the newly diagnosed and relapsed/refractory settings, and with extramedullary disease.

Nucleoporins shape germ granule architecture and balance small RNA silencing pathways.

Animals have evolved distinct small RNA pathways, including piRNA and siRNA, to silence invasive and selfish nucleic acids. piRNA pathway factors are concentrated in perinuclear germ granules that frequently associate with nuclear pore complexes (NPCs). However, the factors mediating germ granule-NPC association and the functional relevance of such association remain unknown.

Roles of the EF-Hand Domain of PLCZ1 in Establishing Species-Specific Ca 2+ Oscillations in Mouse and Rat Fertilization†.

Periodic increases in cytosolic calcium concentration (Ca2+ oscillations) during mammalian fertilization induce all the events collectively known as egg activation. The sperm-specific phospholipase C, PLC zeta 1 (PLCZ1) represents the "sperm factor" vital for initiating the persistent Ca2+ oscillations in mammals. Despite sequence conservation, the Ca2+ oscillation-inducing properties of the enzyme differ vastly among species, and this is particularly salient between mouse and rat PLCZ1, where the activities vary at least one order of magnitude in favor of the former.

Epidemiology and temporal trends of adult inflammatory bowel disease in Taiwan: Multicenter study from the TSIBD registration.

Background: Despite industrialization and advances in healthcare, the prevalence of inflammatory bowel disease (IBD), which encompasses Crohn's disease (CD) and ulcerative colitis (UC), is increasing in Taiwan. Population-based studies can estimate the incidence or prevalence of IBD; however, there is a lack of information regarding the disease phenotype. Therefore, this study was designed to investigate the epidemiologic trends of IBD in Taiwan to gain a more comprehensive understanding.

On the ratios and the logarithms of dark colors in image processing.

In image processing and color science, colors are often specified by their luminance and chromaticity (such as ). Chromaticities are color ratios, which can be difficult to compute reliably due to noise, when the tristimulus values are small, e.g.

Application of attenuated total reflection-Fourier transform infrared spectroscopy in semi-quantification of blood lipids and characterization of the metabolic syndrome.

Background/purpose: Dyslipidemia, a hallmark of metabolic syndrome (MetS), contributes to atherosclerotic and cardiometabolic disorders. Due to days-long analysis, current clinical procedures for cardiotoxic blood lipid monitoring are unmet. This study used AI-assisted attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy to identify MetS and precisely quantify multiple blood lipid levels with a blood sample of 0.

Utilizing a Wireless Radar Framework in Combination With Deep Learning Approaches to Evaluate Obstructive Sleep Apnea Severity in Home-Setting Environments.

Objective: Common examinations for diagnosing obstructive sleep apnea (OSA) are polysomnography (PSG) and home sleep apnea testing (HSAT). However, both PSG and HSAT require that sensors be attached to a subject, which may disturb their sleep and affect the results. Hence, in this study, we aimed to verify a wireless radar framework combined with deep learning techniques to screen for the risk of OSA in home-based environments.

Risk of Variceal Bleeding in Patients Receiving Atezolizumab-Bevacizumab Treatment for Hepatocellular Carcinoma.

Background And Aims: Real-world data on the variceal bleeding (VB) risk in patients receiving atezolizumab-bevacizumab (Atezo-Bev) treatment remain limited. This study aimed to assess the risk of VB and identify risk factors in patients with advanced hepatocellular carcinoma (HCC) receiving Atezo-Bev treatment.

Methods: This retrospective study included 640 patients with HCC who underwent endoscopy before Atezo-Bev treatment at two hospitals in Korea.

Changes in the treatment and outcomes of different severities of neonatal hypoxic ischemic encephalopathy in California: a retrospective cohort study.

Objective: Evaluate the changes in management and outcomes of Californian infants with hypoxic ischemic encephalopathy (HIE).

Study Design: Infants with HIE were identified from a California administrative birth cohort using ICD codes and divided into two epochs, Epoch 1 (2010-2015) and Epoch 2 (2016-2019). Risk ratios (RR) for induced hypothermia (IH) in each epoch and their outcomes were calculated using log-linear regression.

Single-cell analysis of neoplastic plasma cells identifies myeloma pathobiology mediators and potential targets.

Multiple myeloma is a clonal plasma cell (PC) dyscrasia that arises from precursors and has been studied utilizing approaches focused on CD138 cells. By combining single-cell RNA sequencing (scRNA-seq) with scB-cell receptor sequencing (scBCR-seq), we differentiate monoclonal/neoplastic from polyclonal/normal PCs and find more dysregulated genes, especially in precursor patients, than we would have by analyzing bulk PCs. To determine whether this approach can identify oncogenes that contribute to disease pathobiology, mitotic arrest deficient-2 like-1 (MAD2L1) and S-adenosylmethionine synthase isoform type-2 (MAT2A) are validated as targets with drug-like molecules that suppress myeloma growth in preclinical models.

Area-Specific Assessment of Stratum Corneum Hydration and Transepidermal Water Loss in Pediatric Patients With Atopic Dermatitis.

SCORring atopic dermatitis (SCORAD) is widely used to assess the severity of atopic eczema, but score systems based on the entire body may be limited in effective monitoring and intervention. It is crucial to monitor moisture levels in each affected body part, but empirical research is still lacking. The objective of this study was to analyze the levels of stratum corneum hydration (SCH) and transepidermal water loss (TEWL) in atopic dermatitis (AD) patients, focusing on the presence and location of atopic lesions at different body sites.