Ni-Catalyzed Enantioselective Desymmetrization: Development of Divergent Acyl and Decarbonylative Cross-Coupling Reactions.

Ni-catalyzed asymmetric reductive cross-coupling reactions provide rapid and modular access to enantioenriched building blocks from simple electrophile precursors. Reductive coupling reactions that can diverge through a common organometallic intermediate to two distinct families of enantioenriched products are particularly versatile but underdeveloped. Here, we describe the development of a bis(oxazoline) ligand that enables the desymmetrization of -anhydrides.

Quality of life among geriatric population living with functional disabilities: A comparison between urban and rural populations of West Bengal.

Introduction: Global elderly population's growth is evident, with projections reaching 2 billion by 2050, while India's geriatric population is expected to rise to 11.6% by 2026. Disparity in quality of life (QOL) and disabilities between urban and rural elderly exist, where rural elderly maintain active roles, while urban counterparts face economic insecurity post retirement.

Selective Synthesis of -Michael Acceptors via Hydroalkylation of Conjugated Alkynes.

Hydroalkylation of terminal alkynes is a powerful approach to the synthesis of disubstituted alkenes. However, its application is largely unexplored in the synthesis of α,β-unsaturated carbonyls, which are common among synthetic intermediates and biologically active molecules. The thermodynamically less stable -isomers of activated alkenes have been particularly challenging to access because of their propensity for isomerization and the paucity of reliable -selective hydroalkylation methods.

Awareness, Knowledge, and Treatment Patterns of Nonmetastatic Inflammatory Breast Cancer in Low- and Middle-Income Countries: The BRIDGES Study.

Purpose: Trimodal therapy (TMT) is the standard treatment for patients with nonmetastatic inflammatory breast cancer (IBC). TMT consists of neoadjuvant systemic therapy, modified radical mastectomy (MRM), and postmastectomy radiation therapy. Although broadly considered the best approach for IBC, in the United States, only a third of patients receive TMT.

Evaluation of gum odina/carbopol composite mucoadhesive hydrogel on pharmaceutical performance: Focusing on potential periodontal treatment.

Antimicrobial buccal hydrogel made of polymers have gained tremendous utilisation in biomedical field. Dual drug loaded, porous materials are important areas of research for medical and pharmaceutical industries. In this regard, a series of hydrogels (F1, F2, F3) were prepared with gum odina and carbopol 940 in aqueous solution with calcium chloride as the cross linker and glycerol as plasticizer by ionotropic gelation method.

Sexual wellness clinic collaborative initiative with a large urban emergency department: sexual health outcomes and linkage to HIV pre-exposure prophylaxis.

Introduction: Despite escalating rates of sexually transmitted infections (STIs) in the United States (US), there has been progressive divestment of sexual health services leading to the reliance on emergency departments (EDs) for sexual healthcare, particularly among vulnerable populations. The Sexual Wellness Clinic (SWC), a novel care delivery model operating in collaboration with the ED, offers comprehensive sexual health services.

Objectives: This study aims to analyze the demographics, STI positivity, and HIV Pre-Exposure Prophylaxis (PrEP) uptake among patients accessing the SWC.

Psychiatrists' Experiences, Training Needs, and Preferences Regarding Prescription and Management of HIV Pre-exposure Prophylaxis (PrEP) Within Psychiatric Care.

Background: People living with mental illness (PLWMI) experience a disproportionate prevalence and incidence of HIV. Preventing HIV among PLWMI is a priority for multiple domestic public health agencies. As key clinicians for this group, psychiatrists may have an important role to play in increasing PrEP use among PLWMI.

Effect of Size-Controlled Nanofluid on Mechanical Properties, Microstructure, and Rheological Behavior of Cement Slurry for Oil Well Cementing.

The optimal design of cement slurry by balancing various cement additives and cement is critical for effective oil well cementation job. However, given adverse circumstances of application, existing additives may not be sufficient to perform suitably in challenging conditions, leading to premature cement hydration, formation of microcracks, and gas channeling pathways. Thus, this study explores the use of a single-step silica nanofluid (NP size: 5-10, 90-100, and 250-300 nm and concentration: 1, 3, and 5 wt %) as an additive and explores its effect on thickening time, fluid loss, and rheological behavior of class G cement slurry at high-pressure and high-temperature (HPHT) conditions (135 °C and 3625 psi).

Intraspecific variability of rice root knot nematodes across diverse agroecosystems for sustainable management.

In the rice agroecosystems of Southeast Asia, rice root knot nematode (Meloidogyne graminicola) significantly impairs yield, representing a major species within the 'graminis-group' known for its morphological similarities with other root knot nematodes (RKNs). This study delves into the variations in reproductive potential, morphology, morphometrics, and genetic diversity among thirty RKN populations in rice across three distinct agroecological zones in Jharkhand, India. Despite notable differences in reproductive potential among the populations, morphological and morphometric correlations to reproductive potential were inconclusive.

The Role of Fine-Needle Aspiration Cytology in the Evaluation of Breast Lumps.

Background Breast cancer is the most frequently diagnosed cancer in women worldwide, accounting for more than one in ten new cancer cases each year. It ranks as the second leading cause of cancer-related mortality among women. The majority of patients present with palpable breast lumps.

Synthesis of 5,6-substituted benzimidazoles and their evaluation as potential intermediates in the anaerobic vitamin B biosynthesis pathway.

Although benzimidazoles are well-recognized compounds in medicinal chemistry, they occur in the natural world primarily as lower ligands of Vitamin B and other cobamides. In this study, we present the synthesis of 5-methoxy-6-methylbenzimidazole and 5-hydroxy-6-methylbenzimidazole, and demonstrate their ability to produce functional cobamides and N-1'-α-glycosidic-benzimidazolyl-ribosylphosphate isomers which are putative B biosynthesis intermediates.

Assessing body composition through anthropometry: Implications for diagnosing and managing polycystic ovary syndrome (PCOS).

Polycystic ovary syndrome (PCOS) is a multifaceted endocrine disorder with profound implications for the reproductive and metabolic health of women. The utilization of anthropometric measures in the diagnosis and management of PCOS has gained increasing attention due to their practicality and predictive capacity for associated conditions such as obesity and insulin resistance. This review rigorously explores the application of various anthropometric indices, including body mass index, waist-to-hip ratio, and advanced metrics such as the body shape index and body roundness index, wrist circumference, neck circumference.

Improving Cancer Care for Women Seeking Services in the Veterans Health Administration Through the Breast and Gynecological Oncology System of Excellence.

Women are the fastest growing population among Veterans and have substantial risk factors that increase their likelihood for developing cancer. To ensure that the Department of Veterans Affairs Veterans Health Administration (VHA) offers the best possible cancer care to women Veterans, it established the Breast and Gynecologic Oncology System of Excellence (BGSoE) in 2021. The BGSoE offers telehealth oncology services and a comprehensive cancer navigation program.

Effect of Different Ratios of Polyvinyl Alcohol-Gum Odina for the Preparation and Characterization of Biodegradable Composite Films.

This research investigates the production of biodegradable films using a combination of gum odina (GO) and polyvinyl alcohol (PVA) with varied ratio. The study focuses on the chemical, physical, and mechanical properties of PVA-GO composite films, emphasizing how versatile and biodegradable they may be for a range of packaging applications. Solvent-cast PVA-GO films with different ratios are subjected to a methodical analytical process to determine several parameters like mechanical qualities, thermal stability, biodegradability in soil, contact angle, transparency, water vapor permeability, moisture content, thickness, density, water solubility, microstructure, and FTIR analysis.

Anomalous relaxation and hyperuniform fluctuations in center-of-mass conserving systems with broken time-reversal symmetry.

We study the Oslo model, a paradigm for absorbing-phase transition, on a one-dimensional ring of L sites with a fixed global density ρ[over ¯]; we consider the system strictly above critical density ρ_{c}. Notably, microscopic dynamics conserve both mass and center of mass (CoM), but lack time-reversal symmetry. We show that, despite having highly constrained dynamics due to CoM conservation, the system exhibits diffusive relaxation away from criticality and superdiffusive relaxation near criticality.

An Opt-Out Emergency Department Screening Intervention Leads to Major Increases in Diagnosis of Syphilis.

Background: With rising rates of syphilis in the United States, novel strategies are needed to improve early diagnosis, particularly among priority populations such as pregnant people. As the primary source of healthcare for many communities with limited access to care, the emergency department (ED) visit represents a crucial opportunity for syphilis detection and congenital syphilis prevention.

Methods: This pre-post design study examined all ED encounters for 2-year periods before and after implementation of an opt-out ED syphilis screening intervention in May 2019 at a large, urban, academic ED.

Formulation and evaluation of n-acetyl cysteine loaded bi-polymeric physically crosslinked hydrogel with antibacterial and antioxidant activity for diabetic wound dressing.

Diabetic wounds have become a serious global health concern, with a growing number of patients each year. Diabetic altered wound healing physiology, as well as resulting complications, make therapy difficult. Hence, diabetic wound healing necessitates a multidisciplinary strategy.

Surface energy and stress driven growth of extremely long and high-density ZnO nanowires using a thermal step-oxidation process.

Formation of highly crystalline zinc oxide (ZnO) nanowires with an extremely high aspect ratio (length = 60 μm, diameter = 50 nm) is routinely achieved by introducing an intermediate step-oxidation method during the thermal oxidation process of thin zinc (Zn) films. High-purity Zn was deposited onto clean glass substrates at room temperature using a vacuum-assisted thermal evaporation technique. Afterwards, the as-deposited Zn layers were thermally oxidized under a closed air ambient condition at different temperatures and durations.

Understanding Opportunities for Prescribing Pre-exposure Prophylaxis (PrEP) at Two Academic Medical Centers in a High Priority Jurisdiction for Ending the HIV Epidemic.

Introduction: Pre-exposure prophylaxis (PrEP) is an effective, yet underutilized tool for HIV prevention. We sought to understand practice patterns and opportunities for prescribing PrEP across two large, urban, academic healthcare institutions in Chicago, Illinois.

Methods: We analyzed electronic medical record data from two institutions including encounters for persons ≥18 years of age with ≥1 negative HIV test between 1/1/2015-12/31/2021 who had indications for PrEP.

Individual interventions, collective lessons: Developing mid-range theory on women's groups to improve health.

Background: Interventions with women's groups have been widely implemented to improve health outcomes in low- and middle-income settings, particularly India. While there is a large evidence base on the effectiveness of single interventions, it is challenging to predict whether a women's group intervention delivered in one setting can be expected to work in another.

Methods: We applied realist principles to develop and refine a mid-range theory on the effectiveness of women's groups interventions, summarised key lessons for implementation, and reflected on the process.