Parametrization of the dying brain: A case report from ICU bed-side EEG monitoring.

Background: Cortical high-frequency activation immediately before death has been reported, raising questions about an enhanced conscious state at this critical time. Here, we analyzed an electroencephalogram (EEG) from a comatose patient during the dying process with a standard bedside monitor and spectral parameterization techniques.

Methods: We report neurophysiologic features of a dying patient without major cortical injury.

GalNT2-mediated O-glycosylation affects pancreas development and function in mice.

GALNT2, also known as polypeptide N-acetylgalactosaminyltransferase 2, is an enzyme that catalyzes the initial step of O-linked glycosylation, a crucial posttranslational modification that affects protein folding, stability, and function. Alterations in GALNT2 activity have been implicated in various diseases, such as cancer, metabolic disorders, and cardiovascular diseases, highlighting its importance in maintaining normal physiological functions. To investigate the impact of GalNT2 overexpression in vivo for the first time, we generated a conditional transgenic mouse line in which GalNT2 was expressed specifically in the pancreas.

Predicting Digital Accessibility Through a Self-Assessment Test of Process Traits.

We have developed an 11-question self-assessment test that predicts whether a team is likely to develop accessible digital solutions - or not - based on the characteristics of the development processes. Our results indicate the test can predict both successes and failures with regards to accessibility of digital solutions. As such, teams and product leaders now have an easy way to identify whether the team's knowledge, practices and mindset makes them likely to deliver accessible digital solutions.

Feasibility of trauma-focused cognitive behavioural therapy for patients with PTSD and psychosis.

Studies have shown a high prevalence of trauma and PTSD among patients with severe mental illness, but relatively few studies have examined the outcomes of PTSD treatment for this patient group. The aim of this case-series was to assess the feasibility of a Trauma-Focused Cognitive Behavioral Therapy (TF-CBT) intervention for PTSD in people with psychosis. The study examined the possibilities and obstacles when treating this population within clinical settings.

A Rare Case of Magnesium Alkyl Mediated CO-to-Alkoxide Conversion.

Alcohols can be produced by nucleophilic addition at the C=O functional group of ketones or aldehydes. Such C-C bond formations generally proceed smoothly and selective. In contrast, nucleophilic addition at carbon monoxide is considerably more complex and unselective due to the instability of polar metal acyl intermediates.

Variants in LRRC7 lead to intellectual disability, autism, aggression and abnormal eating behaviors.

Members of the leucine rich repeat (LRR) and PDZ domain (LAP) protein family are essential for animal development and histogenesis. Densin-180, encoded by LRRC7, is the only LAP protein selectively expressed in neurons. Densin-180 is a postsynaptic scaffold at glutamatergic synapses, linking cytoskeletal elements with signalling proteins such as the α-subunit of Ca/calmodulin-dependent protein kinase II.

PITX2 deficiency leads to atrial mitochondrial dysfunction.

Aims: Reduced left atrial PITX2 is associated with atrial cardiomyopathy and atrial fibrillation (AF). PITX2 is restricted to left atrial cardiomyocytes (aCMs) in the adult heart. The links between PITX2 deficiency, atrial cardiomyopathy, and AF are not fully understood.

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An efficient, multidimensional instrument is needed to screen non-optimal prenatal parental representations predictive of postnatal parenting behavior and child attachment. The present work aimed to revise and validate the Prenatal Caregiving Expectations Questionnaire-Revised (PCEQ-R). Survey data from two independent samples of pregnant, primarily Danish, women (N = 300/322) were collected to 1) test the factor structure and select items for a 20-item version, and 2) confirm the factor structure, examine internal consistency, and establish initial construct validity.

Mixing and matching ,- and ,-chelates in anionic Mg(I) compounds: synthesis and reactivity with RNCNR and CO.

Reduction of [Mg(NON)] ([NON] = [O(SiMeNDipp)], Dipp = 2,6-iPrCH) affords Mg(I) species containing NON- and NNO-ligands ([NNO] = [N(Dipp)SiMeN(Dipp)SiMeO]). The products of reactions with iPrNCNiPr and CO are consistent with the presence of reducing Mg(I) centres. Extraction with THF affords [K(THF)][(NNO)Mg-Mg(NNO)] with a structurally characterised Mg-Mg bond that was examined using density functional theory.

Diarylformamides as a Safe Reservoir and Room Temperature Source of Ultra-Pure CO in the Context of a 'Green' rWGS Reaction.

Diphenylformamide 1 and bisformamide 9 are shown to be safe reservoirs and sources of CO. Their perfectly selective decarbonylations are achieved in solution at room temperature with potassium and cesium diarylamide catalysts. 1 is obtained in excellent yields directly from triethylammonium formate, which may be the product of CO scrubbing with NEt and catalytic hydrogenation.

Formation, Structure and Reactivity of a Beryllium(0) Complex with Mg-Be Bond Polarization.

Attempts to create a novel Mg-Be bond by reaction of [(BDI*)MgNa] with Be[N(SiMe)] failed; BDI*=HC[(tBu)C=N(DIPeP)], DIPeP=2,6-EtC-phenyl. Even at elevated temperatures, no conversion was observed. This is likely caused by strong steric shielding of the Be center.

Deprescribing of antidepressants: development of indicators of high-risk and overprescribing using the RAND/UCLA Appropriateness Method.

Background: Antidepressants are first-line medications for many psychiatric disorders. However, their widespread long-term use in some indications (e.g.

Similarities and Differences in Benzene Reduction with Ca, Sr, Yb and Sm: Strong Evidence for Tetra-Anionic Benzene.

Inverse sandwich complexes of Yb and Sm stabilized by a bulky β-diketiminate (BDI) ligand have been prepared: (BDI)Ln(η,η-CH)Ln(BDI); Ln=lanthanide. Coordinated benzene ligands can be neutral, di-anionic or, often controversially discussed, even tetra-anionic. The formal charge on benzene is correlated to assignment of the metal oxidation state which generally poses a problem.

The autism susceptibility kinase, TAOK2, phosphorylates eEF2 and modulates translation.

Genes implicated in translation control have been associated with autism spectrum disorders (ASDs). However, some important genetic causes of autism, including the microdeletion, bear no obvious connection to translation. Here, we use proteomics, genetics, and translation assays in cultured cells and mouse brain to reveal altered translation mediated by loss of the kinase TAOK2 in deletion models.

s-Block metal complexes of superbulky (BuSi)N: a new weakly coordinating anion?

Sterically hindered amide anions have found widespread application as deprotonation agents or as ligands to stabilize metals in unusual coordination geometries or oxidation states. The use of bulky amides has also been advantageous in catalyst design. Herein we present s-block metal chemistry with one of the bulkiest known amide ligands: (BuSi)N (abbreviated: N).

Synthesis of Superbulky Amide Ligands by Addition of Polar Reagents to Sila-Imine.

The chemistry of extremely bulky amide ligands is troubled by difficulties in deprotonation of the parent amine. As an alternative route to superbulky amide reagents, the addition of polar reagents to a sila-imine has been investigated. Attempts to synthesize the superbulky amide anion (tBuSi)N by addition of tBuLi to tBuSi=N(SitBu) failed and gave tBuSi(tBuHSi)NLi and isobutene.

Different Forms of TFF3 in the Human Endocervix, including a Complex with IgG Fc Binding Protein (FCGBP), and Further Aspects of the Cervico-Vaginal Innate Immune Barrier.

TFF3 is a typical secretory poplypeptide of mucous epithelia belonging to the trefoil factor family (TFF) of lectins. In the intestine, respiratory tract, and saliva, TFF3 mainly exists as a high-molecular-mass complex with IgG Fc binding protein (FCGBP), which is indicative of a role in mucosal innate immunity. For the first time, we identified different forms of TFF3 in the endocervix, i.

Digital Medication Management in Polypharmacy—Findings of a Cluster-Randomized, Controlled Trial With a Stepped-Wedge Design in Primary Care Practices (AdAM).

Background: Inappropriate drug prescriptions for patients with polypharmacy can have avoidable adverse consequences. We studied the effects of a clinical decision-support system (CDSS) for medication management on hospitalizations and mortality.

Methods: This stepped-wedge, cluster-randomized, controlled trial involved an open cohort of adult patients with polypharmacy in primary care practices (=clusters) in Westphalia-Lippe, Germany.

Disinhibited attachment behavior among infants reared at home: Relations to maternal severe mental illness and personality disorder symptoms.

Disinhibited attachment behavior (DAB) among infants is persistent and associated with behavioral and relational problems throughout childhood and adolescence. Little is known about risk factors for DAB among infants reared at home, although studies have linked DAB with maternal psychiatric hospitalization and maternal borderline personality disorder. The aim of the current study was to further assess the association between DAB, maternal severe mental illness (SMI; schizophrenia, bipolar disorder, and depression), and maternal PD symptoms.

Hair cortisol concentrations in pregnant women with bipolar, depressive, or schizophrenic spectrum disorders.

Purpose: Maternal cortisol levels in pregnancy may support the growth of or adversely affect fetal organs, including the brain. While moderate cortisol levels are essential for fetal development, excessive or prolonged elevations may have negative health consequences for both the mother and the offspring. Little is known about predictors of altered hypothalamic-pituitary-adrenal (HPA) axis activity during pregnancy.

A combined gas-phase dissociative ionization, dissociative electron attachment and deposition study on the potential FEBID precursor [Au(CH)Cl].

Motivated by the potential of focused-electron-beam-induced deposition (FEBID) in the fabrication of functional gold nanostructures for application in plasmonic and detector technology, we conducted a comprehensive study on [Au(CH)Cl] as a potential precursor for such depositions. Fundamental electron-induced dissociation processes were studied under single collision conditions, and the composition and morphology of FEBID deposits fabricated in an ultrahigh-vacuum (UHV) chamber were explored on different surfaces and at varied beam currents. In the gas phase, dissociative ionization was found to lead to significant carbon loss from this precursor, and about 50% of the chlorine was on average removed per dissociative ionization incident.

Metal Vapour Synthesis of an Organometallic Barium(0) Synthon.

A hydrocarbon-soluble barium anthracene complex was prepared by means of metal vapour synthesis. Reaction of 9,10-bis(trimethylsilyl)anthracene (Anth'') with barium vapour gave deep purple Ba(Anth'') which after extraction with diethyl ether crystallised as the cyclic octamer [Ba(Anth'')⋅Et O] . Dissolution in benzene or toluene led to replacement of the Et O ligand with a softer arene ligand and isolation of Ba(Anth'')⋅arene.

Opportunities with calcium Grignard reagents and other heavy alkaline-earth organometallics.

More than a century old, magnesium Grignard reagents remain essential to the toolbox of organic chemists. Although similar reagents with the neighbouring group 2 metal Ca have been explored, the considerably higher polarity and reactivity of the Ca-C bond result in undesired decomposition pathways. Ca Grignard reagents have found academic interest but have never fully developed into an established synthetic tool.

Expression Profiling along the Murine Intestine: Different Mucosal Protection Systems and Alterations in -Deficient Animals.

Tff1 is a typical gastric peptide secreted together with the mucin, Muc5ac. -deficient () mice are well known for their prominent gastric phenotype and represent a recognized model for antral tumorigenesis. Notably, intestinal abnormalities have also been reported in the past in these animals.

SARS-CoV-2 induced changes in the glycosylation pattern in the respiratory tract of Golden Syrian hamsters.

Even after more than two years of intensive research, not all of the pathophysiological processes of Coronavirus Disease 2019 (COVID-19), induced by severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection, have been fully elucidated. The initial virus-host interaction at the respiratory epithelium plays a crucial role in the course and progression of the infection, and is highly dependent on the glycosylation pattern of the host cell and of the secreted mucins. Glycans are polysaccharides that can be attached to proteins and thereby add to their stability and functionality.