Helper cells active in the generation of cytotoxicity to a syngeneic tumor.

We have examined a population of thymic lymphocytes that augment the generation in vitro of specific cytotoxic T cells against P815.X2, a syngeneic tumor in DBA/2 mice. These helper cells are evident in the thymus of DBA/2 mice 5 to 7 days after subcutaneous injection of live P815 cells.

Determination of periodontal disease activity.

The determination of disease activity has a direct impact on therapeutic measures in periodontics. Evaluations that may indicate disease activity have been reviewed under the topics of traditional evaluations, gingival crevicular fluid contents, tissue changes, circulating factors, and sulcular microbiota. The traditional methods, such as probing, radiographs, and clinical indices, were static evaluations that had limited validity in determining disease activity.

The location of the periodontal probe tip in health and disease.

The periodontal probe is used clinically to measure pocket depth and the level of periodontal attachment. In order to be a more reliable, noninvasive method of assessment, it is necessary to investigate the position of the tip of the probe when at rest in the dentogingival junction. Probes were assessed for accuracy, and those closest to a standard millimeter scale were used to make pressure-cast, gold-coated, acrylic replicas.

On the elastic and rigid forms of constrictive pericarditis.

This article discusses a thesis regarding the pathophysiology of constrictive pericarditis. The thesis is that there are two forms of constriction, one being elastic and the other more analogous to a rigid shell. The two forms of constriction are considered to cause different patterns of the diagnostic signs of constriction.

Influence of interdental contacts on periodontal status.

A group of 40 healthy, young adult male naval recruits were examined and scored for gingival inflammation, plaque, food impaction, pocket depth, carious lesions, calculus, restorations and overhangs. The findings of this study support those previously reported in naval recruits, i.e.

The healing of gingival wounds in miniature swine.

Standard wounds of simple incision and partial excision of the dentogingival junction were made in miniature swine. The healing from the 1st to the 14th day were described clinically and histologically, and the standardization of the wounds permitted quantitative and statistical analysis. In wounds that are closely adapted to the tooth, the epithelium of the new dentogingival junction contributes primarily to early wound strength recovery.

Biologic preparation of diseased root surfaces.

Untreated periodontally-involved teeth contain cementum-bound endotoxin, that may prevent periodontal new attachment during healing after pocket therapy. The purpose of this study was to restore biocompatibility to diseased root surfaces by a non-invasive treatment. Untreated human teeth removed for severe chronic periodontal disease were split buccolingually, the level of connective tissue was scribed on the roots, the specimens cleaned of plaque and visible calculus, and autoclaved.

The use of a new topical hemostatic agent.

MICROFIBRILLARY COLLAGEN hemostat (MCH) is described in clinical use as a topical hemostatic agent for control of bleeding at the donor site of the free gingival graft procedures. On the basis of clinical trials, it is an excellent adjunct to periodontal surgical procedures.

The dimensions of meaning and belonging in the process of divorce.

Emotional reactions to divorce are described, with particular reference to the loss of social definition faced by members of the separating family. It is suggested that, for children in particular, disruption of the family matrix constitutes a crisis of meaning and belonging that may be central to the impact of divorce.

The hypermineralization of diseased root surfaces.

Root surfaces which have lost their attachment due to chronic inflammatory periodontal disease present significant increases in calcium, magnesium, phosphorus, and fluoride. The clinical significance of this effect is not known in regards to wound healing, but it may be helpful in control of cervical sensitivity.

The case of Ann: a sleep disturbance in a 3-year-old child.

Ann, a 3 1/2-year-old girl, was brought to a pediatric clinic for a chronic, severe sleep disturbance which had precipitated a serious family crisis. A developmental interactional approach was used by the pediatrician and a social worker who evaluated her case; the problem formulation included a reciprocal separation issue between Ann and her mother. Over a 2-month period, dynamic casework around the behavior problem revealed an unresolved grief reaction.

Induction of lymphocyte proliferation and membrane changes by lipopeptide derivatives of the lipoprotein from the outer membrane of Escherichia coli.

Lipoprotein from the outer membrane of E. coli, a potent novel mitogen, was digested by pronase treatment resulting in lipopeptide fragments containing 2-5 amino acids bound to diacylglyceryl-N-acylcysteinthioether. The lipopeptides were characterized by amino acid analysis and gas chromatography and were checked for mitogenicity.

Aortic stenosis, angina pectoris, and coronary artery disease.

The relationships between aortic stenosis, coronary artery disease, angina pectoris, and myocardial infarction were examined in 173 patients with isolated calcific aortic stenosis who had coronary arteriography as well as cardiac catheterization. All were over age 40 and had definite cardiac symptoms; 156 later had aortic valve replacement. Coronary lesions narrowing the lumen by 50% or more were present in 37% of patients aged 40 to 59 and 68% of those aged 60 to 82.