[Spectrum of the adverse effects of Cordemcura].

Side-effects of Cordemcura were verified in a relatively extensive repertoire of methods. Investigations of blood pressure activity, effect on heart frequency as well as PQ and QT times after continuous infusion, influence on diuresis and antidiuresis and behaviour to achieve results of a possible activity of the central nerve system were given priority. The proved vasodilatory qualities of Cordemcura become also evident in the rat blood pressure reduction due to higher dose as a result of i.

[Modification of smooth muscle contractility by Cordemcura].

Cordemcura causes a dose-dependent inhibition of noradrenaline contractions of isolated rabbit aorta as well as of isolated guinea pig ductus deferens. In both organ preparations analogous intensity of effect has been observed. In different intestinal isolated organs Cordemcura also produces a dose-dependent inhibition against different agonists.

[Cardiac effects of Cordemcura in vitro].

Cordemcura has a dose-dependent inotropic effect in the Langendorff-perfused guinea pig heart, in the isolated spontaneously active atria of the guinea pig as well as in the isolated electrically stimulated rabbit papillary muscle. Tachyphylaxy symptoms and arrhythmogene side-effects have not been observed. The dose-dependent coronardilatory effect caused by Cordemcura as observed at the isolated heart of a guinea-pig appears intensely.

Reproductive outcomes in women exposed to solvents in 36 reinforced plastics companies. I. Menstrual dysfunction.

Recent studies have suggested that exposure to styrene monomer and other solvents is associated with menstrual disturbances. This is the first U.S.

Experimental diabetes: reduction of serotonin-induced vasoconstriction by meclofenamic acid in vitro.

In diabetes the sensitivity of isolated rat aortae to serotonin is greatly diminished and the dose-response curve is shifted to the right. The maximal response is reduced to 37% of control, the threshold dose is approximately tenfold greater, and the ED50 is about fourfold greater than control. This decrease in sensitivity may be due, in part, to a reduction in the synthesis of prostaglandins because serotonin-induced responses in normal and diabetic arteries treated with meclofenamate are also significantly diminished.

[Spasmolytic activity of (3,4-dichloroanilino)phenylacetonitrile (H 74) and its analogs].

The influence of smooth muscle contractility of (3,4-dichloranilino)phenyl-acetonitrile (H 74) was studied in comparison with the analogs (4-chloranilino)phenyl-acetonitrile (H 47) and (3,4,5-trichloranilino)phenyl-acetonitrile (H 84) and several standard pharmaca. H 74 and H 84 showed a spasmolytic action that was almost equal to that of methphenethamine and papaverine. Other investigations have revealed that H 74 was free from any side effect.

[Synthesis and spectrum of pharmacologic action of aryl-arylamino- and aryl-aryliminoacetonitriles].

Aminoacetonitriles were synthetized from arylaldehyde, arylamine and cyanhydrogene. Their dehydrogenation led to the iminoderivatives. The compounds were evaluated for spasmolytic activity in vitro.

Preparing graphics for visual presentation.

In the beginning, the preparations and doing the graphics will take time, and the process will appear to be slow and tedious. Good graphics take time. However, the time will be lessened considerably when you have more hands-on experience.

Study of ampicillin levels in maternal serum, umbilical cord serum and amniotic fluid following administration of pivampicillin.

Premature rupture of the membrane is often followed by intrauterine infections. Antibiotic prophylaxis is recommended, but the effect has been debatable. Thirty pregnant women received pivampicillin 350 mg 4 times daily.

Effect of nonsteroid anti-inflammatory drugs on subarachnoid hemorrhage in dogs.

The effects of two long-acting anti-inflammatory agents on behavioral changes and cerebral vasospasm were evaluated in a canine model of chronic subarachnoid hemorrhage (SAH). The agent with the longest half-life, sudoxicam, clearly reduced both the incidence and the magnitude of the vasopasm, and prevented the usual behavior changes caused by the stimulated SAH. The results obtained with the other agent, naproxen, suggested that it was better than the administration of saline.

[Contribution to the atypical macroglia in nonhepatic diseases (author's transl)].

Frequency and appearance of atypical macroglia in the frontal cortex and striatum in 400 human brains of cases with non-hepatogenic diseases were investigated and compared with results in 150 human brains of cases with severe liver diseases. Quantitative and qualitative differences between the non-hepatogenic (I---III) and hepatogenic (IV) groups were statistically significant. Evidence for the so-called Alzheimer-II-cells could only be obtained in metobolic disturbances of hepatogenic origin and in a few cases of cerebral coma.

Levels and disappearance of prostaglandin F2alpha in cerebral spinal fluid: a clinical and experimental study.

The concentration of prostaglandin F2alpha (PGF2alpha) was measured in cerebrospinal fluid (CSF) obtained by lumbar puncture in patients with subarachnoid hemorrhage and compared to control values. The level of this prostaglandin was elevated at some time in most patients during the course of their illness. However, this could not be correlated with the severity of neurological deficits observed.

Pleocytosis and elevation of prostaglandins F2a and E2 in cerebrospinal fluid following intracisternal injection of thrombin.

A marked pleocytosis and increase in the levels of prostaglandin F2a (PGF2a) and prostaglandin E2 (PGE2) were noted in cerebrospinal fluid of dogs within two hours following the intracisternal injection of thrombin. Quantitation of the prostaglandins (PG's) was done by gas chromatography-mass spectroscopy using deuterated PGF2a and PGE2 as internal standards. Whereas the levels of these prostaglandins were below the sensitivity of the method in control animals, a marked increase was noted following thrombin.

Kinetic enzymatic method for automated determination of glucose in blood and serum.

Studies are reported on the reaction kinetics of the glucose assay according to Trinder which involves the specific oxidation of glucose by glucose oxidase and the determination of the hydrogen peroxide released by means of phenol and 4-aminophenazone in the presence of peroxidase. The results have been used to develop a general kinetic fixed-time method for the analysis of glucose in whole blood and serum. The single reagent method has been adapted to the ENI GEMSAEC centrifugal analyzer and to the Abbott ABA-100 analyzer.