Publications by authors named "H-R Ott"

Cysteine-focused chemical proteomic platforms have accelerated the clinical development of covalent inhibitors for a wide range of targets in cancer. However, how different oncogenic contexts influence cysteine targeting remains unknown. To address this question, we have developed "DrugMap," an atlas of cysteine ligandability compiled across 416 cancer cell lines.

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Primary mediastinal large B-cell lymphoma (PMBCL) is recognized as a distinct entity in the World Health Organization classification. Currently, the diagnosis relies on consensus of histopathology, clinical variables, and presentation, giving rise to diagnostic inaccuracy in routine practice. Previous studies have demonstrated that PMBCL can be distinguished from subtypes of diffuse large B-cell lymphoma (DLBCL) based on gene expression signatures.

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Article Synopsis
  • The study investigates how common periodic limb movements during sleep (PLMS) are in patients who have had a stroke or transient ischemic attack (TIA), along with associated factors.
  • During the research involving polysomnographic recordings of patients and healthy controls, it was found that the occurrence of PLMS was similar in both groups and stable over time.
  • Factors like age, body mass index, and hypertension history were linked to PLMS, but blood pressure and brain damage levels were consistent across patients with and without PLMS, possibly due to increased use of antihypertensive medications in the PLMS group.
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