[The more it changes, the more it remains the same?].

Pr H.-J. Leisinger's farewell lesson treats of the evolution of medicine in general and urology in particular, in a health system submitted to a global change, while emphasizing on the fundamental values of the medical doctor.

Development of recombinant inhibitors specific to human kallikrein 2 using phage-display selected substrates.

The reactive site loop of serpins undoubtedly defines in part their ability to inhibit a particular enzyme. Exchanges in the reactive loop of serpins might reassign the targets and modify the serpin-protease interaction kinetics. Based on this concept, we have developed a procedure to change the specificity of known serpins.