Publications by authors named "H-J Kluge"
Article Synopsis
- The executive summary outlines evidence-based recommendations for diagnosing and treating nosocomial pneumonia, focusing on practical guidelines for healthcare providers in Germany.
- It was developed through a systematic review process by an interdisciplinary panel, with the help of an independent methodologist, and presents 26 total recommendations, including ones based on strong evidence and expert consensus.
- Key recommendations include distinguishing patients at risk for multidrug-resistant pathogens, limitations of routine bacterial PCR testing, and guidelines for antibiotic therapy, emphasizing focused treatments and the importance of rapidly de-escalating unnecessary antibiotics when patients stabilize.
Background The coronavirus disease 2019 (COVID-19) pandemic has spread across the globe with alarming speed, morbidity, and mortality. Immediate triage of patients with chest infections suspected to be caused by COVID-19 using chest CT may be of assistance when results from definitive viral testing are delayed. Purpose To develop and validate an artificial intelligence (AI) system to score the likelihood and extent of pulmonary COVID-19 on chest CT scans using the COVID-19 Reporting and Data System (CO-RADS) and CT severity scoring systems.
View Article and Find Full Text PDFAim: To investigate the relation of two different mutations to the outcome of partial external biliary diversion (PEBD) in severe bile salt export pump (BSEP) deficiency.
Methods: Mutations in the gene encoding BSEP leading to severe BSEP deficiency in two unrelated patients were identified by genomic sequencing. Native liver biopsies and transiently transfected human embryonic kidney (HEK) 293 cells expressing either wild-type or mutated BSEP were subjected to immunofluorescence analysis to assess BSEP transporter localization.