Publications by authors named "H-C Tien"
Article Synopsis
- In March 2020, the White House Coronavirus Task Force identified the need for expert treatment guidelines for managing COVID-19 due to its life-threatening nature and lack of known effective treatments.
- The NIH was tasked with quickly assembling a panel of experts to create "living" guidelines, which would be regularly updated as new information about the virus emerged.
- The article reflects on the Panel's experiences over four years, summarizes its final recommendations, discusses ongoing challenges, and notes that the responsibility for COVID-19 guidelines will now shift to professional organizations following the end of the public health emergency.
Article Synopsis
- - Persistent inflammation from HIV contributes to cardiovascular disease (CVD), driven notably by innate immune cells like monocytes, leading to this study's focus on the roles of non-classical and intermediate monocytes in this context.
- - The study assessed women with and without chronic HIV infection and subclinical CVD, using ultrasound to identify plaques, and compared gene expression in monocytes between those with different HIV/CVD statuses and healthy controls.
- - Findings revealed that while intermediate monocytes showed limited gene expression changes with HIV or CVD alone, coexisting conditions produced distinct gene signatures, which were eliminated with lipid-lowering treatment, and non-classical monocytes exhibited significant changes, especially in cases of comorbid HIV and CVD
Background: The nuclear receptor Rev-erbα/β, a key component of the circadian clock, emerges as a drug target for heart diseases, but the function of cardiac Rev-erb has not been studied in vivo. Circadian disruption is implicated in heart diseases, but it is unknown whether cardiac molecular clock dysfunction is associated with the progression of any naturally occurring human heart diseases. Obesity paradox refers to the seemingly protective role of obesity for heart failure, but the mechanism is unclear.
View Article and Find Full Text PDFEffect of the non-ideal axial ratio c/a on anharmonic EXAFS oscillation of h.c.p. crystals.
J Synchrotron Radiat
September 2021
The temperature and wavenumber dependence of the extended X-ray absorption fine-structure (EXAFS) oscillation of hexagonal close-packed (h.c.p.
View Article and Find Full Text PDFArticle Synopsis
- The NIH COVID-19 Treatment Guidelines were initiated in March 2020 following a request from the White House Coronavirus Task Force, leading to the establishment of a diverse panel that included experts from multiple sectors to create and update treatment recommendations.
- Within two weeks, the initial guidelines were published online, but the rapid evolution of COVID-19 treatment data necessitated 24 updates in the first year, reflecting the dynamic nature of clinical research.
- Key lessons learned from this process include the importance of accessible, credible guidelines, the value of collaboration among various health entities, the necessity for well-designed clinical trials, and the need for frequent updates to adapt to new evidence.
Subclinical kidney disease is associated with developing hypertension in the general population, but data are lacking among HIV-infected people. We examined associations of kidney function and injury with incident hypertension in 823 HIV-infected and 267 HIV-uninfected women in the Women's Interagency HIV Study, a multicenter, prospective cohort of HIV-infected and uninfected women in the United States. Baseline kidney biomarkers included estimated glomerular filtration rate using cystatin C, urine albumin-to-creatinine ratio, and 7 urine biomarkers of tubular injury: α-1-microglobulin, interleukin-18, kidney injury molecule-1, neutrophil gelatinase-associated lipocalin, liver fatty acid-binding protein, N-acetyl-β-d-glucosaminidase, and α1-acid-glycoprotein.
View Article and Find Full Text PDFBackground: Trauma procedural and management skills are often learned on live tissue. However, there is increasing pressure to use simulators because their fidelity improves and as ethical concerns increase. We randomized military medical technicians (medics) to training on either simulators or live tissue to learn combat casualty care skills to determine if the choice of modality was associated with differences in skill uptake.
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