- The study investigated a diverse group of 95 enzymes from the N-terminal nucleophile hydrolase superfamily, focusing on their ability to hydrolyze synthetic polyamides like nylon.
- About 40% of these enzymes demonstrated significant nylon hydrolase activity, comparable to the well-known enzyme NylC, without any clear link between their evolutionary relationships and their hydrolytic capabilities.
- Researchers identified several enzymes with strong substrate selectivity, especially those that efficiently processed Nylon 6,6, and also analyzed the crystal structure of a specific hydrolase to better understand the factors affecting its activity and selectivity.
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