Publications by authors named "H van der Pas"
The quartification model is an SU(3)4 extension with a bi-fundamental fermion sector of the well-known SU(3)3 bi-fundamentalfication model. An alternative "flipped" version of the quartification model is obtained by rearrangement of the particle assignments. The flipped model has two standard (bi-fundamentalfication) families and one flipped quartification family.
View Article and Find Full Text PDFPemphigus vulgaris (PV) is a rare autoimmune bullous disease characterized by blistering of the skin and mucosa owing to the presence of autoantibodies against the desmosome proteins desmoglein 3 and occasionally in conjunction with desmoglein 1. Fundamental research into the pathogenesis of PV has revolutionized its treatment and outcome with rituximab, a B-cell-depleting therapy. The critical contribution of B cells to the pathogenesis of pemphigus is well accepted.
View Article and Find Full Text PDFArticle Synopsis
- Epidermolysis bullosa (EB) is a genetic skin condition that causes blistering due to mutations in proteins that help bind skin layers together.
- A study tracked 15 patients with recessive dystrophic or junctional EB, analyzing their blood for autoantibodies related to autoimmune blistering diseases.
- Results showed that patients with recessive dystrophic EB had a significantly higher chance (70%) of developing these autoantibodies compared to those with junctional EB (20%), with reactivity most notably against specific collagen types and other proteins.