Publications by authors named "H van Luenen"
The diverse range of organizations contributing to the global research ecosystem is believed to enhance the overall quality and resilience of its output. Mid-sized autonomous research institutes, distinct from universities, play a crucial role in this landscape. They often lead the way in new research fields and experimental methods, including those in social and organizational domains, which are vital for driving innovation.
View Article and Find Full Text PDFCore facilities play a central role in the life sciences by generating data and ensuring quality standards. Their contributions to research should be appropriately acknowledged or cited in research papers.
View Article and Find Full Text PDFComprehensive Cancer Centres (CCCs) serve as critical drivers for improving cancer survival. In Europe, we have developed an Excellence Designation System (EDS) consisting of criteria to assess "excellence" of CCCs in translational research (bench to bedside and back), with the expectation that many European CCCs will aspire to this status.
View Article and Find Full Text PDFTranslational research leaves no-one indifferent and everyone expects a particular benefit. We as EU-LIFE (www.eu-life.
View Article and Find Full Text PDFArticle Synopsis
- Base J (β-D-glucosyl-hydroxymethyluracil) is a modified nucleobase in the Leishmania genome, replacing 1% of thymine (T) mainly in telomeric regions and transcription sites.
- JBP1 and JBP2 are thymidine hydroxylases that initiate the synthesis of Base J, which specifically targets DNA sequences recognized during this process.
- Research using SMRT sequencing revealed that J modifications typically occur at pairs of Ts on opposite strands and are dependent on JBP2, supporting a model where JBP2 facilitates new J insertions while JBP1 maintains it during DNA replication.