[Child and adolescent psychiatric consultation encourages the transformation of youth care, but collaboration is not yet self-explanatory].

Background: The mission in Dutch youth care is to work together to help the child and its family in the best possible way. Child and adolescent psychiatric consultation seems a good way to contribute to this mission, but this is not self-explanatory. Many colleagues feel uncertain how to maintain their medical responsibility.

Aberrant Wnt signaling in multiple myeloma: molecular mechanisms and targeting options.

Aberrant activation of Wnt/β-catenin signaling plays a central role in the pathogenesis of a wide variety of malignancies and is typically caused by mutations in core Wnt pathway components driving constitutive, ligand-independent signaling. In multiple myelomas (MMs), however, these pathway intrinsic mutations are rare despite the fact that most tumors display aberrant Wnt pathway activity. Recent studies indicate that this activation is caused by genetic and epigenetic lesions of Wnt regulatory components, sensitizing MM cells to autocrine Wnt ligands and paracrine Wnts emanating from the bone marrow niche.