Outcomes after index cholecystectomy: a UK longitudinal multi-centre cohort Study.

Purpose: International guidelines for management of acute biliary pathology recommend emergency cholecystectomy (EmC), citing improved outcomes compared to elective cholecystectomy (ElC) based on trials which may not reflect the capacity constraints in clinical practice, nor selection based on multiple prior attendances with emergency biliary pathology or attendances following a decision for ElC. We therefore conducted a longitudinal retrospective study evaluating all attendances with biliary pathology prior to cholecystectomy with the aim of assessing whether EmC is justified in this context.

Methods: Data was collected on patients undergoing cholecystectomy between 2016 and 2021 at four centres.

Insight into the Environmental Health Consciousness of Medical Students Regarding the Perceived Impacts of Climate Change on Human Health.

Climate change represents an unprecedented global public health crisis with extensive and profound implications. The Lancet Commission identified it as the foremost health challenge of the 21st century. In 2015, air pollution alone caused approximately 9 million premature deaths worldwide.

Evaluating the necessity of postoperative day 1 labs following laparoscopic radical nephrectomy (LRN).

Background: Standard postoperative care following laparoscopic radical nephrectomy (LRN) typically includes routine blood tests. Recent studies have assessed the safety of omitting routine postoperative labs in minimally invasive surgeries to reduce hospital costs. Our primary objective was to evaluate if routine postoperative day 1 (POD1) labs were necessary following LRN.

Comparative efficacy, safety, and oncological outcomes of percutaneous thermal and chemical ablation modalities for recurrent metastatic cervical lymphadenopathy from thyroid cancer.

Background: Thermal and chemical ablation techniques may consolidate recurrent metastatic cervical lymph nodes as alternatives to repeat neck dissection in thyroid cancer patients. This meta-analysis aims to compare the efficacy and safety across modalities.

Methods: Four databases were searched for studies on radiofrequency (RFA), microwave (MWA), laser (LA), and ethanol ablation (EA) treating metastatic cervical nodes from thyroid cancer.

Emerging paradigm: Molecularly targeted therapy with Dabrafenib and Trametinib in recurring pediatric gliomas with BRAF mutations: A narrative review.

Gliomas are tumors arising in the central nervous system, frequently associated with Class I mutations and BRAF fusions. These mutations are adverse prognostic factors in juvenile gliomas, leading to high rates of recurrence and poor response to current treatments. The blood-brain barrier and the heterogeneity of gliomas complicate the development of a single treatment strategy for all cases.